2,4-DIFLUORO-5-NITROANILINE

Product Name: 2,4-DIFLUORO-5-NITROANILINE
CAS No.: 123344-02-5
Chemical Name: 2,4-DIFLUORO-5-NITROANILINE
Synonyms: 2,4-DIFLUORO-5-NITROANILINE;Benzenamine, 2,4-difluoro-5-nitro-
CBNumber: CB3131475
Molecular Formula: C6H4F2N2O2
Formula Weight: 174.1
MOL File: Mol file

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2,4-DIFLUORO-5-NITROANILINE Property

Melting point:: 94-96°C
Boiling point:: 309.4±37.0 °C(Predicted)
Density: 1.554±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 1.02±0.10(Predicted)
Appearance: Brown to black Solid

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Safety

HS Code: 2921490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Synthonix

Product number: D42110
Product name: 2,4-Difluoro-5-nitroaniline
Purity: 98%
Packaging: 100mg
Price: $63
Updated: 2026/05/06

Synthonix

Product number: D42110
Product name: 2,4-Difluoro-5-nitroaniline
Purity: 98%
Packaging: 250mg
Price: $68
Updated: 2026/05/06

Synthonix

Product number: D42110
Product name: 2,4-Difluoro-5-nitroaniline
Purity: 98%
Packaging: 1g
Price: $69
Updated: 2026/05/06

Synthonix

Product number: D42110
Product name: 2,4-Difluoro-5-nitroaniline
Purity: 98%
Packaging: 5g
Price: $70
Updated: 2026/05/06

Synthonix

Product number: D42110
Product name: 2,4-Difluoro-5-nitroaniline
Purity: 98%
Packaging: 10g
Price: $120
Updated: 2026/05/06

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2,4-DIFLUORO-5-NITROANILINE Chemical Properties,Usage,Production

Uses

2,4-Difluoro-5-nitroaniline is intended for research use only and is not for human or veterinary use.

Synthesis

367-25-9

123344-02-5

Step 1: Synthesis of 2,4-difluoro-5-nitroaniline (71) At 0 °C, 2,4-difluoroaniline (0.394 mL, 3.87 mmol) was dissolved in concentrated sulfuric acid (5 mL, 94 mmol). Nitric acid (0.272 mL, 375 mg, 3.87 mmol) was added slowly and dropwise over 20 min. The reaction mixture was continued to be stirred at 5 °C for 30 min. Subsequently, the reaction mixture was poured into ice water and extracted with ether. The organic layer was washed with saturated NaHCO3 solution and after drying and evaporating the solvent, the target compound 2,4-difluoro-5-nitroaniline (71) was obtained (467 mg, 69.3% yield). NMR data (400 MHz, CDCl3): δ 3.91 (broad peak, 2H), 6.98 (triple peak, J = 10.2 Hz, 1H), 7.51 (double double peaks, J = 8.6 Hz and 7.0 Hz, 1H).

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 19, p. 8027 - 8054
[2] Patent: CN107793413, 2018, A. Location in patent: Paragraph 0168-0171
[3] Patent: WO2011/147764, 2011, A1. Location in patent: Page/Page column 75-76
[4] Patent: US2013/79341, 2013, A1. Location in patent: Paragraph 0249
[5] Journal of Medicinal Chemistry, 2013, vol. 56, # 1, p. 241 - 253

2,4-DIFLUORO-5-NITROANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-DIFLUORO-5-NITROANILINE Suppliers

China 65 India 2 Switzerland 1 Ukraine 1 United Kingdom 2 United States 11 Global 82

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