ChemicalBook > CAS DataBase List > Scopolamine butylbromide
Scopolamine butylbromide
- Product Name
- Scopolamine butylbromide
- CAS No.
- 149-64-4
- Chemical Name
- Scopolamine butylbromide
- Synonyms
- HYOSCINE BUTYLBROMIDE;buscopan;HYOSCINE N-BUTYL BROMIDE;(1S,2R,4S,5S)-9-butyl-7-[(3-hydroxy-2-phenylpropanoyl)oxy]-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane bromide;buscol;scobro;donopon;joscine;scobron;Stibron
- CBNumber
- CB9126868
- Molecular Formula
- C21H30BrNO4
- Formula Weight
- 440.37
- MOL File
- 149-64-4.mol
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Scopolamine butylbromide Property
- Melting point:
- 142-1440C
- alpha
- D20 -20.8° (c = 3 in water)
- storage temp.
- 2-8°C
- solubility
- H2O: 50 mg/mL
- form
- powder
- color
- white
- optical activity
- [α]25/D 20.8°, c = 3 in H2O(lit.)
- CAS DataBase Reference
- 149-64-4(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- S7882
- Product name
- (?)-Scopolamine N-butyl bromide
- Purity
- ≥98% (TLC), powder
- Packaging
- 1g
- Price
- $54.7
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- S7882
- Product name
- (?)-Scopolamine N-butyl bromide
- Purity
- ≥98% (TLC), powder
- Packaging
- 5g
- Price
- $171
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- BP198
- Product name
- Hyoscine butylbromide
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $229
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 27223
- Product name
- Scopolamine N-butyl (bromide)
- Packaging
- 1g
- Price
- $44
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 27223
- Product name
- Scopolamine N-butyl (bromide)
- Packaging
- 10g
- Price
- $299
- Updated
- 2024/03/01
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Scopolamine butylbromide Chemical Properties,Usage,Production
Chemical Properties
Crystalline Solid
Originator
Butylscopolamine,China Pharm
Uses
(?)-Scopolamine N-butyl bromide was used as standard in designing a procedure for quantification of compounds using CE-MS.8
Uses
Anticholinergic. Antispasmodic
Definition
ChEBI: Butylscopolamine bromide is an organic bromide salt of butylscopolamine. It is an antispasmodic drug which can relieve painful stomach cramps (including those linked with irritable bowel syndrome), bladder and menstrual cramps. It has a role as a muscarinic antagonist and an antispasmodic drug. It is an organic bromide salt and a quaternary ammonium salt. It contains a butylscopolamine.
Manufacturing Process
1300 g of scopolamine base and 350 g of n-butylbromide in 600 ml acetonitrile is heated at 65°C for 160 hours. The oil obtained is dissolved in methanol. The solution is cooled and crystalline scopolamine N-n-butylbromide is filtered. After recrystallization from methanol was obtained scopolamine N-n-butylbromide with melting point 142-144°C and [α]d 20 = -20.5° (3% solution in water); yield 65%.
Therapeutic Function
Anticholinergic, Spasmolytic, Antitussive
Biochem/physiol Actions
Competitive muscarinic acetylcholine receptor antagonist; antispasmodic.
Clinical Use
Symptomatic relief of gastrointestinal or genitourinary
disorders due to smooth muscle spasm
Bowel colic
Excessive respiratory secretions
target
AChR
Metabolism
The main metabolic pathway is the hydrolytic cleavage of the ester bond. Orally administered hyoscine butylbromide is excreted in the faeces and in the urine. Studies in man show that 2-5% of radioactive doses is eliminated renally after oral, and 0.7-1.6% after rectal administration. Approximately 90% of recovered radioactivity can be found in the faeces after oral administration. The urinary excretion of hyoscine butylbromide is less than 0.1% of the dose. The metabolites excreted via the renal route bind poorly to muscarinic receptors and are therefore not considered to contribute to the effect of the hyoscine butylbromide.
Scopolamine butylbromide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Scopolamine butylbromide manufacturers
Changsha Staherb Natural Ingredients Co., Ltd.
- Product
- Scopolamine butylbromide; Flos?daturae extract 149-64-4
- Price
- US $0.00/G
- Min. Order
- 1G
- Purity
- ≥99% HPLC
- Supply Ability
- 1000KG
- Release date
- 2022-09-16
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
- Product
- Scopolamine butylbromide 149-64-4
- Price
- US $999.00-800.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-21
Wuhan Circle Star Chem-medical Technology Co.,Ltd
- Product
- Scopolamine butylbromide 149-64-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98
- Supply Ability
- 1000
- Release date
- 2025-01-10
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