ChemicalBook > CAS DataBase List > 2-Amino-5-Bromo-3-Nitrobenzotrifluoride

2-Amino-5-Bromo-3-Nitrobenzotrifluoride

Product Name: 2-Amino-5-Bromo-3-Nitrobenzotrifluoride
CAS No.: 157026-18-1
Chemical Name: 2-Amino-5-Bromo-3-Nitrobenzotrifluoride
Synonyms: 2-Amino-5-Bromo-3-Nitrobenzotrifluoride;2-Nitro-4-bromo-6-trifluoromethylaniline;4-Bromo-2-nitro-6-(trifluoromethyl)aniline;4-bromo-2-nitro-6-(trifluoromethyl)Benzenamine;Benzenamine, 4-bromo-2-nitro-6-(trifluoromethyl)-;4-Bromo-2-nitro-6-(trifluoromethyl)aniline, 2-Amino-5-bromo-3-(trifluoromethyl)nitrobenzene
CBNumber: CB91270850
Molecular Formula: C7H4BrF3N2O2
Formula Weight: 285.02
MOL File: 157026-18-1.mol

Less

2-Amino-5-Bromo-3-Nitrobenzotrifluoride Property

Melting point:: 70-72°C
Boiling point:: 273.5±35.0 °C(Predicted)
Density: 1.859±0.06 g/cm3(Predicted)
storage temp.: Hygroscopic, Refrigerator, under inert atmosphere
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: -3.75±0.25(Predicted)
form: Solid
color: Dark Yellow

Less

Safety

HS Code: 2921430090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

Less

N-Bromosuccinimide Price

TRC

Product number: B699340
Product name: 4-Bromo-2-nitro-6-(trifluoromethyl)aniline
Packaging: 2.5g
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: W3411
Product name: 4-Bromo-2-nitro-6-(trifluoromethyl)aniline
Packaging: 250mg
Price: $89
Updated: 2021/12/16

Matrix Scientific

Product number: 074054
Product name: 4-Bromo-2-nitro-6-(trifluoromethyl)aniline
Purity: 95+%
Packaging: 1g
Price: $347
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 37762
Product name: 4-Bromo-2-nitro-6-(trifluoromethyl)aniline
Purity: 95+%
Packaging: 5G
Price: $687
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0043957
Product name: 4-BROMO-2-NITRO-6-TRIFLUOROMETHYL-PHENYLAMINE
Purity: 95.00%
Packaging: 1G
Price: $779.63
Updated: 2021/12/16

Less

2-Amino-5-Bromo-3-Nitrobenzotrifluoride Chemical Properties,Usage,Production

Uses

4-Bromo-2-nitro-6-(trifluoromethyl)aniline is a reagent for the preparation of 3-(5-arylbenzimidazol-2-yl)-1-oxa-2-azaspiro[4.5]decenes, a transient receptor potential melastatin 8 (TRPM8) antagonist for the treatment of painful conditions related to cold.

Synthesis

29124-62-7

157026-18-1

Step B: Synthesis of 4-bromo-2-nitro-6-(trifluoromethyl)aniline 1. Cool sulfuric acid (350 mL) to 5°C in an ice bath. 2. add N-(4-bromo-2-(trifluoromethyl)phenyl)acetamide (100 g, 355 mmol) in one batch, controlling the internal temperature between 5°C and 10°C. 2. add N-(4-bromo-2-(trifluoromethyl)phenyl)acetamide (100 g, 355 mmol) in one batch. 3. after the solid is completely dissolved and the temperature is reduced to 5°C, slowly add 70% nitric acid (43.8 mL) dropwise, making sure the internal temperature does not exceed 10°C. 4. Maintain the reaction temperature between 8°C and 12°C until the reaction is complete. 5. Carefully pour the reaction solution into stirred ice water (2 L, mostly ice). 6. The tan precipitate was collected by filtration and the filter cake was washed with cold water (1 L) and subsequently air dried. 7. The resulting tan powder was placed in a 3 L three-necked flask and methanol (500 mL) was added to make a slurry. 8. 37% concentrated hydrochloric acid (750 mL, 9130 mmol) was added and heated to 100°C using a heating shield. care was taken to control excessive foaming. 9. To reduce foaming, 1,4-dioxane (100 mL) and tetrahydrofuran (200 mL) were added. 10. lower the reaction temperature to 80°C and continue heating overnight for better foam control. 11. Slowly increase temperature to 95°C with stirring for 72 hours. 12. cool to room temperature and extract three times with ethyl acetate. 13. The organic layers were combined, washed with brine, dried over sodium sulfate and concentrated to give 2-amino-5-bromo-3-nitrobenzotrifluoride (101 g, 99%). 1H NMR (400 MHz, DMSO-d6) δ ppm: 8.40 (d, 1H), 7.96 (d, 1H), 7.44 (br.s, 2H).

References

[1] Patent: WO2011/97491, 2011, A1. Location in patent: Page/Page column 117-118
[2] Journal of Medicinal Chemistry, 1995, vol. 38, # 22, p. 4367 - 4379
[3] Patent: WO2011/97491, 2011, A1
[4] Patent: US5514680, 1996, A

2-Amino-5-Bromo-3-Nitrobenzotrifluoride Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2-Amino-5-Bromo-3-Nitrobenzotrifluoride Suppliers

China 86 India 1 United Kingdom 1 United States 6 Global 94

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Wuhan ariel chemical Co., LTD.

Tel: 18986259541
Fax: 027-87840182
Email: sales@3stc.com
Country: China
ProdList: 3764
Advantage: 58

Tianjin Jinyuda Chemical Co., Ltd.

Tel: 022-58013646 13011382049
Fax: 022-23854368
Email: sales@jinyudachem.com
Country: China
ProdList: 1930
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

EnliPharma Technology Co., Ltd

Tel: 0551-66399836 18955197623
Email: sales@enlipharma.com
Country: China
ProdList: 1876
Advantage: 55

Shanghai Huikai Chemical Technology Co., Ltd.

Tel: 021-61995394 18916691159
Email: chemicalsea@163.com
Country: China
ProdList: 1972
Advantage: 58

NINGBO INNO PHARMCHEM CO.,LTD.

Tel: 86-574-27787657
Fax: 86-574-27912196
Email: info@dearchem.com
Country: China
ProdList: 4613
Advantage: 58

Xinyanhe Pharmatech Co.,Ltd

Tel: 0519-85252752 15366845260
Fax: 86-0519-85683352
Email: taihuaren@vip.163.com
Country: China
ProdList: 1124
Advantage: 58

Nanjing Chalf-Pharm Technology Co., Ltd.

Tel: 025-57018978 18251899859
Fax: 025-57018008
Email: sales@chalf-pharm.com
Country: China
ProdList: 5674
Advantage: 50

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16679
Advantage: 50

NovoChemy Ltd.

Tel: 86-(0)21-31261262 373522135
Fax: 86-(0)21-33250524
Email: sales@novochemy.com
Country: China
ProdList: 6498
Advantage: 58

Wuhan Chemwish Technology Co.， Ltd

Tel: 027-67849912
Fax: 027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 9148
Advantage: 60

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886750 13927877953
Fax: 0751-2886750
Email: 3005811397@qq.com
Country: China
ProdList: 13305
Advantage: 58

Nanijing m&m biotechnology Co. ,Ltd.

Tel: 025-87782433 18021532344
Fax: 025-87782433
Email: 1345332203@qq.com
Country: China
ProdList: 4135
Advantage: 58

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 9998
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

SHANGHAI FDC-CHEMICAL CO.,LTD

Tel: 021-61469567 13482353728
Fax: 021-61161605
Email: sales@fdc-chemical.com
Country: China
ProdList: 9722
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Suzhou Xiya Pharmaceutical Co., Ltd.

Tel: 0512-87819718 18912655635
Email: 2587879032@qq.com
Country: China
ProdList: 1403
Advantage: 58

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 021-50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12878
Advantage: 58

ROSEWA HOLDING GROUP CO.,LIMITED

Tel: +86-023-62871537
Email: sales@rosewachem.com
Country: China
ProdList: 2803
Advantage: 58

Allfluoro pharmaceutical co. ltd.

Tel: +86-400-0216110 +86-15958047586
Fax: 0086-21-33275002
Email: sales@allfluoro.com
Country: China
ProdList: 11385
Advantage: 58

CR Corporation Limited

Tel: +8613062833949
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 8645
Advantage: 58

Changzhou Helios Biomedical Science and Technology Co.,LTD.

Tel: +8618961213068
Email: gaoxue@czhelios.com
Country: China
ProdList: 512
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Win-Win chemical CO., Limited

Tel: +86-0086-577-64498589 +86-15355981851
Fax: 0086-577-56994596
Email: sales@win-winchemical.com
Country: China
ProdList: 14359
Advantage: 58

HUNAN CHEMFISH SCIENTIFIC CO.,LTD

Tel: +86-0731-85567275 13298656710
Fax: QQ:3554193828
Email: sales05@chemfish.com
Country: China
ProdList: 7448
Advantage: 58

Henan Weituxi Chemical Technology Co., Ltd.

Tel: 0371-63284658 18135795563
Fax: QQ:2885349392
Email: 2885349392@qq.com
Country: China
ProdList: 9992
Advantage: 58

Hubei xin bonus chemical co. LTD

Tel: 86-13657291602
Fax: 027-59338440
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 22963
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39927
Advantage: 58

Wuhan Chemwish Technology Co., Ltd

Tel: 027-67849912
Email: sales@chemwish.com
Country: CHINA
ProdList: 10821
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-87569262 +86-15003564040
Fax: 029-88380327
Email: 1087@dideu.com
Country: China
ProdList: 3979
Advantage: 58

Fuxin Pharmaceutical

Tel: +86-021-021-50872116 +8613122107989
Email: contact@fuxinpharm.com
Country: China
ProdList: 10000
Advantage: 58

Antai Fine Chemical Technology Co.,Limited

Tel: 18503026267
Email: info@antaichem.com
Country: CHINA
ProdList: 9636
Advantage: 58

Shanghai Xiushi Biomedical Co., LTD

Tel: 15002184385 15021598081 15002184385
Email: product001@xiushipharm.com
Country: China
ProdList: 4719
Advantage: 58

Changzhou Helios Biomedical Science and Technology Co.,LTD.

Tel: 18961213068
Email: 121257724@qq.com
Country: China
ProdList: 493
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Shanghai Xuanlin Pharmaceutical Technology Co., Ltd

Tel: 13955239259
Fax: QQ3450014153 ;
Email: 3295742260@qq.com
Country: China
ProdList: 976
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Shanghai Hanlin biology science and technology co., ltd

Tel: 183-0212-4410 18302124410
Email: Djt18302124410@163.com
Country: China
ProdList: 3000
Advantage: 58

Hefei Mokai Pharmaceutical Technology Co., Ltd

Tel: 18130062233
Email: 3362556465@qq.com
Country: China
ProdList: 8100
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Less

View Lastest Price from 2-Amino-5-Bromo-3-Nitrobenzotrifluoride manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Amino-5-Bromo-3-Nitrobenzotrifluoride 157026-18-1
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-13

Hangzhou ICH Biofarm Co., Ltd

Product: 2-Amino-5-Bromo-3-Nitrobenzotrifluoride 157026-18-1
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 20 tons
Release date: 2023-07-12

Career Henan Chemical Co

Product: 2-Amino-5-Bromo-3-Nitrobenzotrifluoride 157026-18-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-01

157026-18-1, 2-Amino-5-Bromo-3-NitrobenzotrifluorideRelated Search:

3-Nitrobenzotrifluoride 5-BROMO-3-METHYL-BENZENE-1,2-DIAMINE 2-Amino-5-Bromo-3-Nitrobenzotrifluoride 3-BROMO-5-NITROBENZOTRIFLUORIDE 3-Amino-5-bromobenzotrifluoride 5-BROMO-2,3-DIAMINOBENZOTRIFLUORIDE 4-Bromo-2-methyl-6-nitroaniline

2-Amino-5-Bromo-3-Nitrobenzotrifluoride

4-Bromo-2-nitro-6-(trifluoromethyl)aniline

4-Bromo-2-nitro-6-(trifluoromethyl)aniline, 2-Amino-5-bromo-3-(trifluoromethyl)nitrobenzene

4-bromo-2-nitro-6-(trifluoromethyl)Benzenamine

Benzenamine, 4-bromo-2-nitro-6-(trifluoromethyl)-

2-Nitro-4-bromo-6-trifluoromethylaniline

157026-18-1

Trifluoromethylbenzene serise