1H-Pyrazol-3-amine,5-(1-methylethoxy)-(9CI)
- Product Name
- 1H-Pyrazol-3-amine,5-(1-methylethoxy)-(9CI)
- CAS No.
- 121507-34-4
- Chemical Name
- 1H-Pyrazol-3-amine,5-(1-methylethoxy)-(9CI)
- Synonyms
- 100075;5-isopropoxy-1H-pyrazole-3-amine;3-propan-2-yloxy-1H-pyrazol-5-amine;5-(1-Methylethoxy)-1H-Pyrazol-3-amine;5-(propan-2-yloxy)-1H-pyrazol-3-aMine;1H-Pyrazol-3-aMine, 5-(1-Methylethoxy)-;1H-Pyrazol-3-amine,5-(1-methylethoxy)-(9CI)
- CBNumber
- CB91280767
- Molecular Formula
- C6H11N3O
- Formula Weight
- 141.17
- MOL File
- 121507-34-4.mol
1H-Pyrazol-3-amine,5-(1-methylethoxy)-(9CI) Property
- storage temp.
- 2-8°C, protect from light
- Appearance
- Off-white to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I918228
- Product name
- 5-Isopropoxy-1H-pyrazol-3-amine
- Packaging
- 2.5g
- Price
- $495
- Updated
- 2021/12/16
- Product number
- 3914AA
- Product name
- 5-Isopropoxy-1H-pyrazol-3-amine
- Packaging
- 1g
- Price
- $344
- Updated
- 2021/12/16
- Product number
- 071128
- Product name
- 5-Isopropoxy-1H-pyrazol-3-amine
- Purity
- 97%
- Packaging
- 500mg
- Price
- $360
- Updated
- 2021/12/16
- Product number
- 071128
- Product name
- 5-Isopropoxy-1H-pyrazol-3-amine
- Purity
- 97%
- Packaging
- 1g
- Price
- $620
- Updated
- 2021/12/16
- Product number
- 3914AA
- Product name
- 5-Isopropoxy-1H-pyrazol-3-amine
- Packaging
- 5g
- Price
- $922
- Updated
- 2021/12/16
1H-Pyrazol-3-amine,5-(1-methylethoxy)-(9CI) Chemical Properties,Usage,Production
Uses
5-Isopropoxy-1H-pyrazol-3-amine pois involved with the synthesis and biol. evaluation of 2-(α-arylalkylamino)-4-(pyrazolylamino)pyrimidines as potent inhibitors of Trk kinases.
Synthesis
53666-79-8
67-63-0
121507-34-4
(Step 1) Preparation of 5-isopropoxy-1H-pyrazol-3-amine: methanesulfonic acid (25 mL) was slowly added to a solution of isopropanol (250 mL) containing 3-amino-5-hydroxypyrazole (25 g) with continuous stirring. The reaction mixture was heated to 120 °C and maintained for 2 days. Upon completion of the reaction, the reaction solution was cooled to room temperature and the solvent was subsequently removed by distillation under reduced pressure. Saturated aqueous sodium bicarbonate was added to the residue to neutralize the acid, followed by extraction with ethyl acetate. The organic phases were combined and dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the organic phase was concentrated under reduced pressure to afford the target product 5-isopropoxy-1H-pyrazol-3-amine (5.35 g, 15% yield).
References
[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 15, p. 4672 - 4684
[2] Patent: US2011/9622, 2011, A1. Location in patent: Page/Page column 38
[3] Patent: WO2008/135785, 2008, A1. Location in patent: Page/Page column 52-53
1H-Pyrazol-3-amine,5-(1-methylethoxy)-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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