ChemicalBook > CAS DataBase List > CAPTOPRIL DISULFIDE

CAPTOPRIL DISULFIDE

Product Name: CAPTOPRIL DISULFIDE
CAS No.: 64806-05-9
Chemical Name: CAPTOPRIL DISULFIDE
Synonyms: SQ 14551;CAPTOPRDS;CAPTOPRIL DISULFIDE;Captopril-Disuphide;Captopril Impurity J;Captopril Impurity G;Captopril Impurity A;Captopril IMp. A (BP);CAPTOPRIL DISULFIDE USP;Captopril EP IMpurity A
CBNumber: CB9129834
Molecular Formula: C18H28N2O6S2
Formula Weight: 432.55
MOL File: 64806-05-9.mol

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CAPTOPRIL DISULFIDE Property

Melting point:: 224-226°C
Boiling point:: 714.8±60.0 °C(Predicted)
Density: 1.383±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly, Sonicated)
form: Solid
pka: 3.29±0.20(Predicted)
color: White to Off-White

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Safety

WGK Germany: 3
HS Code: 2933999552

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1091221
Product name: Captopril disulfide
Packaging: 100mg
Price: $1200
Updated: 2025/07/31

Sigma-Aldrich

Product number: BP500
Product name: Captopril disulfide
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 25MG
Price: $266
Updated: 2024/03/01

Cayman Chemical

Product number: 28018
Product name: Captopril Disulfide
Packaging: 5mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 28018
Product name: Captopril Disulfide
Packaging: 25mg
Price: $513
Updated: 2024/03/01

Cayman Chemical

Product number: 28018
Product name: Captopril Disulfide
Packaging: 10mg
Price: $230
Updated: 2024/03/01

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CAPTOPRIL DISULFIDE Chemical Properties,Usage,Production

Description

Captopril disulfide is a metabolite and symmetrical disulfide form of the angiotensin converting enzyme (ACE) inhibitor captopril . Captopril disulfide is the main degradation product of captopril and is formed by oxidation. It is a potential impurity in commercial preparations of captopril. Captopril disulfide inhibits angiotensin I-induced increases in mean arterial pressure in anesthetized dogs (ID₅₀ = 0.231 mg/kg, i.v.).

Chemical Properties

White Solid

Uses

Captopril Disulfide (Captopril EP Impurity A) is a metabolite of Captopril. A new antihypertensive agent.

Definition

ChEBI: An organic disulfide in which the disulfide bond links two units of captopril. It is a secondary metabolite of captopril.

References

[1] T KOMAI. In vitro studies on the metabolic pathway of SQ 14225 (Captopril) and mechanism of mixed disulfide formation.[J]. Journal of pharmacobio-dynamics, 1981, 4 9: 677-684. DOI: 10.1248/bpb1978.4.677
[2] BENEDETTA PASQUINI . Cyclodextrin- and solvent-modified micellar electrokinetic chromatography for the determination of captopril, hydrochlorothiazide and their impurities: A Quality by Design approach[J]. Talanta, 2016, 160: Pages 332-339. DOI: 10.1016/j.talanta.2016.07.038
[3] N O’HARA K H H Ono. Potentiation of bradykinin-induced decrease of blood pressure in dogs by SO 14,551, the disulfide metabolite of captopril.[J]. Japanese journal of pharmacology, 1982, 32 5: 934-937. DOI: 10.1254/jjp.32.934

CAPTOPRIL DISULFIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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64806-05-9, CAPTOPRIL DISULFIDERelated Search:

Ion pair reagent Captopril 1-[(2R)-3-Hydroxy-2-Methyl-1-oxopropyl]-L-proline Canagliflozin Dimer alpha-Capecitabine 5'-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine CAPECITABINE related substance USP (2S)-1-[(2S)-2-Methyl-3-Methylsulfinylpropanoyl]pyrrolidine-2-carboxylic acid 5'-deoxy-5-fluore-N-[(pentoyloxy)carbonyl]cytidine 2',3'-diacetate pentyl(1-((2R,3R,4R,5R)-3,4-bis(((2S,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)oxy)-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate 2'-O-(5'-Deoxy-β-D-ribofuranosyl) Capecitabine 5'-Deoxy-5-fluorocytidine 1-[(2S)-3-BroMo-2-Methyl-1-oxopropyl]-L-proline (2S)-1-[2-Methylpropanoyl]-pyrrolidine-2-carboxylic Acid Captopril tablets DIISOBUTYL DISULFIDE CAPTOPRIL DISULFIDE CAPTOPRIL IMP. A (EP): CAPTOPRIL DISULPHIDE MM

CAPTOPRIL DISULFIDE

CAPTOPRIL DISULFIDE USP

CAPTOPRIL DISULFIDE USP(CRM STANDARD)

CAPTOPRIL DISULFIDE WHO(CRM STANDARD)

CAPTOPRIL DISULPHIDE BP STANDARD

Captopril ImpurityⅠ:Captopril Disulfide{ 1,1'-[Dithiobis[(2S)-2-methyl-1-oxo-3,1-propanediyl]]bis-L-proline CAPTOPRDS}

Imp. A (EP):1,1'-[Disulfanediylbis-[(2S)-2-methyl-1-oxopropane-3,1-diyl]]-bis[(2S)-pyrrolidine-2-carboxylic] Acid(Captopril Disulfide)

Captopril Impurity A

Captopril Impurity G

Captopril Impurity J

(2S,2'S)-1,1'-[Disulphanediylbis[(2S)-2-methyl-1-oxopropane-3,1-diyl]-bis[pyrrolidine-2-carboxylic] acid

Captopril Impurity 1(Captopril EP Impurity A)

CAPTOPRIL DISULPHIDE BP STANDARD(CRM STANDARD)

CAPTOPRIL DISULPHIDE BP(CRM STANDARD)

1,1'-[Dithiobis[(2S)-2-methyl-1-oxo-3,1-propanediyl]]bis-L-proline

CAPTOPRDS

SQ 14551

(1,1-[Dithiobis[(2S)-2-methyl-1-oxo-3,1-propanediyl]]bis-L-proline CAPTOPRDS

1,1'-[Dithiobis[(S)-2-methyl-1-oxo-3,1-propanediyl]]bis-L-proline

Captopril Disulfide (100 mg)

Captopril Disulde (100 mg)

Captopril IMp. A (BP)

Captopril EP IMpurity A

Captopril-Disuphide

1,1'-[Disulfanediylbis-[(2S)-2-meth

L-Proline, 1,1'-[dithiobis[(2S)-2-methyl-1-oxo-3,1-propanediyl]]bis-

CaptoprilDisuphide(CaptoprilImpurityI)

Captopril EP Impurity A-d6

Captopril EP Impurity A (Captopril disulphide)

Captopril ImpurityⅠ:Captopril Disulfide{ 1,1’-[Dithiobis[(2S)-2-methyl-1-oxo-3,1-propanediyl]]bis-L-proline CAPTOPRDS}

Captopril Disulfide (1091221)

(2S,2'S)-1,1'-((2S,2'S)-3,3'-disulfanediylbis(2-methylpropanoyl))bis(pyrrolidine-2-carboxylic acid)

1,1′-[disulfanediylbis[(2S)-2-methyl-1-oxopropane-3,1- diyl]]bis[(2S)-pyrrolidine-2-carboxylic] acid

1,1'-[Disulfanediylbis-[(2S)-2-methyl-1-oxopropane-3,1-diyl]]-bis[(2S)-pyrrolidine-2-carboxylic] Aci

1,1'-[Disulfanediylbis-[(2S)-2-methyl-1-oxopropane-3,1-diyl]]-bis[(2S)-pyrrolidine-2-carboxylic] Acid (Captopril Disulfide)

64806-05-9

64806-05-09

C18H28N2O6S2

43255

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