1H-Benzimidazol-5-ol,1-methyl-(9CI)
- Product Name
- 1H-Benzimidazol-5-ol,1-methyl-(9CI)
- CAS No.
- 50591-22-5
- Chemical Name
- 1H-Benzimidazol-5-ol,1-methyl-(9CI)
- Synonyms
- 1-Methyl-1H-benzo[d]iMidazol-5-ol;1-Methylbenzimidazol-5-ol;1H-Benzimidazol-5-ol, 1-methyl-;1H-Benzimidazol-5-ol,1-methyl-(9CI)
- CBNumber
- CB91301840
- Molecular Formula
- C8H8N2O
- Formula Weight
- 148.16
- MOL File
- 50591-22-5.mol
1H-Benzimidazol-5-ol,1-methyl-(9CI) Property
- Boiling point:
- 337.7±34.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 8.90±0.40(Predicted)
- Appearance
- Off-white to light brown Solid
- InChI
- InChI=1S/C8H8N2O/c1-10-5-9-7-4-6(11)2-3-8(7)10/h2-5,11H,1H3
- InChIKey
- NDDDURSMVVKBTL-UHFFFAOYSA-N
- SMILES
- C1N(C)C2=CC=C(O)C=C2N=1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M321583
- Product name
- 1-Methyl-1H-benzimidazol-5-ol
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- OR961057
- Product name
- 1-Methyl-1H-benzimidazol-5-ol
- Purity
- 98%
- Packaging
- 250mg
- Price
- $218
- Updated
- 2021/12/16
- Product number
- 136936
- Product name
- 1-Methyl-1H-benzimidazol-5-ol
- Purity
- 95%+
- Packaging
- 1g
- Price
- $393
- Updated
- 2021/12/16
- Product number
- OR961057
- Product name
- 1-Methyl-1H-benzimidazol-5-ol
- Purity
- 98%
- Packaging
- 1g
- Price
- $537
- Updated
- 2021/12/16
- Product number
- V6275
- Product name
- 1-Methyl-1h-benzimidazol-5-ol
- Packaging
- 5g
- Price
- $618
- Updated
- 2021/12/16
1H-Benzimidazol-5-ol,1-methyl-(9CI) Chemical Properties,Usage,Production
Uses
1-methyl-1H-benzimidazol-5-ol is a useful reactant for the preparation of substituted azaquinazolinones as modulators of GHSr-1a for the treatment of type II diabetes and obesity
Synthesis
10394-39-5
50591-22-5
Boron tribromide (3.1 g, 12.33 mmol) was slowly added dropwise to a solution of 5-methoxy-1-methyl-1H-benzo[d]imidazole (500 mg, 3.08 mmol) in dichloromethane (6 mL) at 0 °C. After the dropwise addition was completed, the reaction mixture was kept at 0 °C and stirring was continued for 2 hours. Subsequently, the reaction was quenched by slow addition of ice water (50 mL). The reaction mixture was extracted with dichloromethane (2 x 20 mL). The organic layers were combined, washed with brine (30 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford 1-methyl-1H-benzimidazol-5-ol (100 mg, 21.9% yield) as a white solid, which could be used in the subsequent reaction without further purification.LCMS (m/z): 149.1 ([M+H]+).
References
[1] Patent: WO2014/100730, 2014, A1. Location in patent: Paragraph 00301
1H-Benzimidazol-5-ol,1-methyl-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-Benzimidazol-5-ol,1-methyl-(9CI) manufacturers
- Product
- 1H-Benzimidazol-5-ol,1-methyl-(9CI) 50591-22-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-09-28
- Product
- 1-Methyl-1h-benzimidazol-5-ol 50591-22-5
- Price
- US $0.00-0.00/MG
- Min. Order
- 10MG
- Purity
- 98% HPLC
- Supply Ability
- 10000
- Release date
- 2024-09-20