1H-Benzimidazol-5-ol
- Product Name
- 1H-Benzimidazol-5-ol
- CAS No.
- 41292-65-3
- Chemical Name
- 1H-Benzimidazol-5-ol
- Synonyms
- 5-Benzimidazolol;1H-BenziMidazol-6-ol;1H-Benzimidazol-5-ol;3H-benzimidazol-5-ol;3H-BenzoiMidazol-5-ol;1H-benzimidazole-5-ol;5-hydroxybenzimidazole;1H-1,3-benzodiazol-5-ol;1H-benzo[d]iMidazol-6-ol;Lansoprazole Impurity 69
- CBNumber
- CB41239119
- Molecular Formula
- C7H6N2O
- Formula Weight
- 134.14
- MOL File
- 41292-65-3.mol
1H-Benzimidazol-5-ol Property
- Melting point:
- 220-222℃
- Boiling point:
- 469.1±18.0 °C(Predicted)
- Density
- 1.434±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 9.20±0.40(Predicted)
- Appearance
- Brown to black Solid
- InChI
- InChI=1S/C7H6N2O/c10-5-1-2-6-7(3-5)9-4-8-6/h1-4,10H,(H,8,9)
- InChIKey
- KRKSOBREFNTJJY-UHFFFAOYSA-N
- SMILES
- C1NC2=CC(O)=CC=C2N=1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CBR02476
- Product name
- 1H-Benzimidazol-5-ol hydrobromide
- Purity
- AldrichCPR
- Packaging
- 1G
- Price
- $259
- Updated
- 2025/07/31
- Product number
- B130865
- Product name
- 1H-Benzo[D]Imidazol-5-ol
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 280071
- Product name
- 6-Hydroxy-1H-benzimidazole
- Packaging
- 25mg
- Price
- $333
- Updated
- 2021/12/16
- Product number
- 4H01-1-P5
- Product name
- 6-Hydroxy-1H-benzimidazole
- Packaging
- 250mg
- Price
- $26
- Updated
- 2021/12/16
- Product number
- 4H01-1-P5
- Product name
- 6-Hydroxy-1H-benzimidazole
- Packaging
- 1g
- Price
- $79
- Updated
- 2021/12/16
1H-Benzimidazol-5-ol Chemical Properties,Usage,Production
Uses
1H-Benzo[D]Imidazol-5-ol is a pathway intermediate in the anaerobic biosynthesis of the lower ligand of vitamin B12 (cobalamin).
Definition
ChEBI: 5-hydroxybenzimidazole is a member of the class of benzimidazoles that is 1H-benzimidazole carrying a single hydroxy substituent at position 5. It has a role as a human metabolite, a rat metabolite and a bacterial metabolite. It is a member of benzimidazoles and a member of phenols. It derives from a hydride of a 1H-benzimidazole.
Synthesis
4887-80-3
41292-65-3
General procedure for the synthesis of 1H-benzimidazol-5-ol from 5-methoxybenzimidazole: 5-methoxybenzimidazole (500 mg, 3.374 mmol) was dissolved in 48% hydrobromic acid (10 mL) and the reaction was carried out at reflux for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by rotary evaporator under reduced pressure. The residue was azeotropically treated with toluene (50 mL) to give the final title compound 1H-benzimidazol-5-ol as a brown solid (701 mg, 96% yield).
References
[1] Patent: WO2007/76034, 2007, A2. Location in patent: Page/Page column 125
[2] Journal of the American Chemical Society, 1955, vol. 77, p. 5192
[3] Synthetic Communications, 2010, vol. 40, # 12, p. 1765 - 1771
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 7, p. 2620 - 2623
1H-Benzimidazol-5-ol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-Benzimidazol-5-ol manufacturers
- Product
- 1H-Benzimidazol-5-ol 41292-65-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2019-12-31