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5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole

Product Name
5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
CAS No.
97963-62-7
Chemical Name
5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
Synonyms
5-DIFLUOROMETHOXY-2-MERCAPTO-1H-BENZIMIDAZOLE;5-(DifluoroMethoxy)-1H-benzo[d]iMidazole-2-thiol;5-Difluormethoxy-2-Mercapto-1-H-Benimidazole;Pantoprazole-3;SKA 47;5-Difluoro;BUTTPARK 16\03-28;5-(DifluoroMethoxy)-;PANTOPRAZOLE EP IMP C;Ditluoro Benzimidazole
CBNumber
CB7493780
Molecular Formula
C8H6F2N2OS
Formula Weight
216.21
MOL File
97963-62-7.mol
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5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole Property

Melting point:
239-243 °C(lit.)
Boiling point:
303.5±52.0 °C(Predicted)
Density 
1.52±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
9.77±0.30(Predicted)
color 
Pale Yellow
InChI
InChI=1S/C8H6F2N2OS/c9-7(10)13-4-1-2-5-6(3-4)12-8(14)11-5/h1-3,7H,(H2,11,12,14)
InChIKey
HJMVPNAZPFZXCP-UHFFFAOYSA-N
SMILES
C1(=S)NC2=CC=C(OC(F)F)C=C2N1
CAS DataBase Reference
97963-62-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-36/37
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900
Storage Class
11 - Combustible Solids
Hazard Classifications
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR3075
Product name
Pantoprazole Related Compound C
Purity
pharmaceutical secondary standard, certified reference material
Packaging
50MG
Price
$336.3
Updated
2025/07/31
Sigma-Aldrich
Product number
542210
Product name
5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
Purity
97%
Packaging
5g
Price
$45.3
Updated
2025/07/31
Sigma-Aldrich
Product number
1494920
Product name
Pantoprazole Related Compound C
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
20mg
Price
$1200
Updated
2025/07/31
TCI Chemical
Product number
D3438
Product name
5-(Difluoromethoxy)-2-mercaptobenzimidazole
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$35
Updated
2025/07/31
TRC
Product number
D445835
Product name
5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
Packaging
100g
Price
$700
Updated
2021/12/16
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5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

Pantoprazole EP Impurity C. Pantoprazole USP Related Compound C.

General Description

5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole may be used in the synthesis of pantoprazole, a drug for treating gastroesophageal reflux disease and gastrointestinal disorders.

Synthesis

75-15-0

172282-50-7

97963-62-7

In a four-necked flask equipped with a mechanical stirrer, a reflux condenser and a thermometer, the alkaline solution was prepared: 6.6 g of sodium carbonate was dissolved in 20 g of tap water, stirred until completely dissolved, cooled slightly, and then 34.8 g of 4-(difluoromethoxy)benzene-1,2-diamine was added, stirring was continued for 20 minutes. The reaction mixture was heated to 30°C and 20 g of carbon disulfide was slowly added dropwise, controlling the dropwise temperature at 25-35°C. After the dropwise addition was completed, the temperature was raised to 30-40°C and the condensation reaction was maintained at this temperature for 6 hours. Subsequently, continue heating to 60-70°C and maintain this temperature for cyclization for 6 hours. After the reaction was completed, activated carbon was added for decolorization. The pH of the filtrate was adjusted to 5-6 with sulfuric acid, and after filtration, washing and drying, 33.2 g of 5-difluoromethoxy-2-mercapto-1H-benzimidazole was obtained in 95.4% yield (based on 4-(difluoromethoxy)benzene-1,2-diamine).

References

[1] Patent: CN103539746, 2016, B. Location in patent: Paragraph 0037; 0038
[2] Advanced Synthesis and Catalysis, 2018, vol. 360, # 21, p. 4161 - 4167

5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole Suppliers

Americas 1 Belgium 1 Canada 3 China 353 Europe 3 France 2 Germany 4 India 112 Japan 3 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 18 United States 44 Global 550
Shanghai Qiao Chemical Science Co., Ltd
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021-58892003
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info@qiaochem.com
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China
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Jinan Dexinjia Bio&Tech Co., Ltd
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053182375892 15098789112
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0531-82375893
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haiyao@jndxj.com
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China
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Shanghai RC Chemicals Co. Ltd
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17305617782
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86-21-50322176
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sales1@rcc.net.cn
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China
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Guangzhou Greensyn Co., Ltd.
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China
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Shanghai Joiny Pharmaceutical Co.,Ltd.
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13681955282
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gyd@joiny-pharma.com
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China
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Xiamen keerda Biotechnology Co., Ltd
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0592-5639388; 18060983084
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China
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J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006356688 18621169109
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86-21-61259102
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market03@meryer.com
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China
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INTATRADE GmbH
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+49 3493/605464
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+49 3493/605470
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sales@intatrade.de
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Germany
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future industrial shanghai co., ltd
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400-0066400 13621662912
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021-55660885
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sales@jonln.com
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China
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View Lastest Price from 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole 97963-62-7
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200kg
Release date
2022-12-13
Hebei Dangtong Import and export Co LTD
Product
5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole 97963-62-7
Price
US $100.00-60.00/kg
Min. Order
100kg
Purity
99.99%
Supply Ability
100Tons
Release date
2023-03-06
Hebei Chuanghai Biotechnology Co,.LTD
Product
5- (Difluoromethoxy) -2-Mercapto-1h-Benzimidazole 97963-62-7
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-22

97963-62-7, 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazoleRelated Search:

PANTOPRAZOLE SULPHONE SODIUM SALT (Trifluoromethoxy)benzene Benzimidazole 2-Mercaptobenzimidazole 4-(Trifluoromethoxy)aniline Phenformin 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole 2-(Trifluoromethoxy)aniline tert-Butyl 4-(4-nitropyridin-3-yl)piperazine-1-carboxylate 5-Methyl-3,4-diphenylisoxazole 4-(5-methyl-4-phenylisoxazol-3-yl)benzenesulfonamide Parecoxib Impurity H Parecoxib Impurity 16 Parecoxib Impurity 18 Parecoxib Impurity 20 Parecoxib Impurity 14 Parecoxib Impurity 16 Parecoxib Impurity 13

  • Pantoprazole-3
  • 5-DIFLUOROMETHOXY - 2 - MERCAPTO - 1H BE
  • 5-(Difluoromethoxy)-2-mercapto-1H-benz
  • 5-Difluormethoxy-2-Mercapto-1-H-Benimidazole
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  • 5-(DifluoroMethoxy)-
  • Pantoprazole Related CoMpound C
  • 5-(DifluoroMethoxy)-1H-benzo[d]iMidazole-2-thiol
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  • 5-(difluoroMethoxy)-1H-1,3-benzodiazole-2-thiol
  • 5 - two fluorine Methoxy - 2 - Mercapto - 1 h - benzene and iMidazole
  • SKA 47
  • 5-Difluormethoxy-2-mercaepto-1H-benzimidazole
  • BUTTPARK 16\03-28
  • 5-DIFLUORMETHOXY-2-MERCAPTO-1-1-1-BENZIMIDAZOLE
  • 5-DIFLUORMETHOXY-2-MERCAPTO-1-H-BENZIMIDAZOLE
  • 5-(DIFLUOROMETHOXY)-2-BENZIMIDAZOLETHIOL
  • 5-DIFLUOROMETHOXY-2-MERCAPTO-1H-BENZIMIDAZOLE
  • 5-(DIFLUOROMETHOXY)-2-MERCAPTOBENZIMIDAZOLE
  • 5-DIFLUOROMETHOXY-2-THIO-BENZIMIDAZOLE
  • 5-(DIFLUOROMETHOXY)-2-MERCAPTO-1H-BENZI
  • 1H-2-MERCAPTO-5-(DIFLUORO METHOXY) BENZIMIDAZOLE ≥98%
  • 5-Difuormethoxy-2-Mercapto-1-H-Benzinmidazole
  • 5-(Difluoromethoxy)-2-Mercapto-1H-Enzimidazole
  • 5-Difluoromethoxy-2-mercapto-1H-Benzimidazole(Pantoprazole Intermediate
  • 5-Difluormethoxy-2-Mercapto-1H-Benzinmidazole
  • 5-Difluoro
  • 5-Difluoromethoxy-2-mercapto-1H-benzimidazole 99%
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  • 2-Mercapto 5-Difluoromethoxy-1H-benzimidazole
  • 5-(difluoromethoxy)-1,3-dihydrobenzimidazole-2-thione
  • pantoprazole benzmimdazole
  • 5-(Difluoromethoxy)-1,3-dihydro-2H-benzo[d]imidazole-2-thione
  • Pantoprazole Impurity 3(Pantoprazole EP Impurity C)
  • 5-Difluromethoxy-2-Mercapto Benzimidazole
  • 5-DIFLUORO-2-MERCAPTO-H BENZIMIDAZOLE
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  • 2H-Benzimidazole-2-thione, 5-(difluoromethoxy)-1,3-dihydro-
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  • 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole ISO 9001：2015 REACH
  • Pantoprazole intermediates，5-Difluoromethoxy-2-mercapto-1H- benzimidazole
  • 5-(Difluoromethoxy)-2- mercapto-1H benzimidazole5-(Difluoromethoxy)-2- mercapto-1H benzimidazole
  • 1-H-2-mercapto-5-difluoromethoxylbenzimidazole
  • 5-Difluoromethoxy-2-mercapto-1-H-Benzimidazole (Panto BZL)
  • 5-difluoromethoxy - 2-mercaptoxy - 1h-benzimidazole
  • 5-(Difluoromethoxy)-1,3-dihydro-2H-benzo[d]imidazole-2-thione (Pantoprazole Impurity)
  • Pantoprazole EP Impurity C/ Pantoprazole Related Compound C (Pantoprazole Thiol Impurity)
  • 5-(Difluoro methoxy)-2-mercapto-1H-benzimidazoleQ: What is 5-(Difluoro methoxy)-2-mercapto-1H-benzimidazole Q: What is the CAS Number of 5-(Difluoro methoxy)-2-mercapto-1H-benzimidazole Q: What is the storage condition of 5-(Difluoro methoxy)-2-mercapto-1H-benzimidazole Q: What are the applications of 5-(Difluoro methoxy)-2-mercapto-1H-benzimidazole
  • Pantoprazole Related Compound C (5-(difluoromethoxy)-1H-benzimidazole-2-thiol) (1494920)
  • 5-difluoromethoxy-2-mercapto1-hydrobenzimidazole