5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
- Product Name
- 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
- CAS No.
- 97963-62-7
- Chemical Name
- 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
- Synonyms
- 5-DIFLUOROMETHOXY-2-MERCAPTO-1H-BENZIMIDAZOLE;5-(DifluoroMethoxy)-1H-benzo[d]iMidazole-2-thiol;5-Difluormethoxy-2-Mercapto-1-H-Benimidazole;Pantoprazole-3;SKA 47;5-Difluoro;BUTTPARK 16\03-28;5-(DifluoroMethoxy)-;PANTOPRAZOLE EP IMP C;Ditluoro Benzimidazole
- CBNumber
- CB7493780
- Molecular Formula
- C8H6F2N2OS
- Formula Weight
- 216.21
- MOL File
- 97963-62-7.mol
5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole Property
- Melting point:
- 239-243 °C(lit.)
- Boiling point:
- 303.5±52.0 °C(Predicted)
- Density
- 1.52±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 9.77±0.30(Predicted)
- color
- Pale Yellow
- InChI
- InChI=1S/C8H6F2N2OS/c9-7(10)13-4-1-2-5-6(3-4)12-8(14)11-5/h1-3,7H,(H2,11,12,14)
- InChIKey
- HJMVPNAZPFZXCP-UHFFFAOYSA-N
- SMILES
- C1(=S)NC2=CC=C(OC(F)F)C=C2N1
- CAS DataBase Reference
- 97963-62-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-36/37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PHR3075
- Product name
- Pantoprazole Related Compound C
- Purity
- pharmaceutical secondary standard, certified reference material
- Packaging
- 50MG
- Price
- $336.3
- Updated
- 2025/07/31
- Product number
- 542210
- Product name
- 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
- Purity
- 97%
- Packaging
- 5g
- Price
- $45.3
- Updated
- 2025/07/31
- Product number
- 1494920
- Product name
- Pantoprazole Related Compound C
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 20mg
- Price
- $1200
- Updated
- 2025/07/31
- Product number
- D3438
- Product name
- 5-(Difluoromethoxy)-2-mercaptobenzimidazole
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $35
- Updated
- 2025/07/31
- Product number
- D445835
- Product name
- 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
- Packaging
- 100g
- Price
- $700
- Updated
- 2021/12/16
5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Solid
Uses
Pantoprazole EP Impurity C. Pantoprazole USP Related Compound C.
General Description
5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole may be used in the synthesis of pantoprazole, a drug for treating gastroesophageal reflux disease and gastrointestinal disorders.
Synthesis
75-15-0
172282-50-7
97963-62-7
In a four-necked flask equipped with a mechanical stirrer, a reflux condenser and a thermometer, the alkaline solution was prepared: 6.6 g of sodium carbonate was dissolved in 20 g of tap water, stirred until completely dissolved, cooled slightly, and then 34.8 g of 4-(difluoromethoxy)benzene-1,2-diamine was added, stirring was continued for 20 minutes. The reaction mixture was heated to 30°C and 20 g of carbon disulfide was slowly added dropwise, controlling the dropwise temperature at 25-35°C. After the dropwise addition was completed, the temperature was raised to 30-40°C and the condensation reaction was maintained at this temperature for 6 hours. Subsequently, continue heating to 60-70°C and maintain this temperature for cyclization for 6 hours. After the reaction was completed, activated carbon was added for decolorization. The pH of the filtrate was adjusted to 5-6 with sulfuric acid, and after filtration, washing and drying, 33.2 g of 5-difluoromethoxy-2-mercapto-1H-benzimidazole was obtained in 95.4% yield (based on 4-(difluoromethoxy)benzene-1,2-diamine).
References
[1] Patent: CN103539746, 2016, B. Location in patent: Paragraph 0037; 0038
[2] Advanced Synthesis and Catalysis, 2018, vol. 360, # 21, p. 4161 - 4167
5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole Preparation Products And Raw materials
Raw materials
Preparation Products
5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole Suppliers
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View Lastest Price from 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole manufacturers
- Product
- 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole 97963-62-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2022-12-13
- Product
- 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole 97963-62-7
- Price
- US $100.00-60.00/kg
- Min. Order
- 100kg
- Purity
- 99.99%
- Supply Ability
- 100Tons
- Release date
- 2023-03-06
- Product
- 5- (Difluoromethoxy) -2-Mercapto-1h-Benzimidazole 97963-62-7
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-22