2-FLUOROPYRIDINE-3-BORONIC ACID PINACOL ESTER
- Product Name
- 2-FLUOROPYRIDINE-3-BORONIC ACID PINACOL ESTER
- CAS No.
- 452972-14-4
- Chemical Name
- 2-FLUOROPYRIDINE-3-BORONIC ACID PINACOL ESTER
- Synonyms
- 2-Fl;2-fluoropyridine-3-borate acid;2-Fluoropyridine-3-boronic 2-FLUOROPYRIDINE-3-BORONIC ACID PICOL ESTER;2-Fluoro-3-pyridylboronic acid pinacol ester;2-FLUOROPYRIDINE-3-BORONIC ACID PINACOL ESTER;2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborol;2-Fluoropyridine-3-boronic acid, pinacol ester 95%;2-Fluoropyridine-3-boronic acid pinacol ester ,98%;pyridine, 2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborol
- CBNumber
- CB9130203
- Molecular Formula
- C11H15BFNO2
- Formula Weight
- 223.05
- MOL File
- 452972-14-4.mol
2-FLUOROPYRIDINE-3-BORONIC ACID PINACOL ESTER Property
- Melting point:
- 42-45°C
- Boiling point:
- 309.9±27.0 °C(Predicted)
- Density
- 1.09±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- -0.44±0.12(Predicted)
- color
- yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F1105
- Product name
- 2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $52
- Updated
- 2025/07/31
- Product number
- F1105
- Product name
- 2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $153
- Updated
- 2025/07/31
- Product number
- F596213
- Product name
- 2-Fluoropyridine-3-boronicacid,pinacolester
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- F596213
- Product name
- 2-Fluoropyridine-3-boronicacid,pinacolester
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- X1360
- Product name
- 2-Fluoropyridine-3-boronicacidpinacolester
- Packaging
- 10g
- Price
- $181
- Updated
- 2021/12/16
2-FLUOROPYRIDINE-3-BORONIC ACID PINACOL ESTER Chemical Properties,Usage,Production
Chemical Properties
White to light yellow solid
Uses
2-Fluoropyridine-3-boronic acid, pinacol ester
Synthesis
372-48-5
25015-63-8
452972-14-4
Freshly distilled diisopropylamine (42.5 g, 0.42 mol) was dissolved in ether under nitrogen protection and cooled to 0°C. n-Butyllithium (2.5 M, 175 mL) was slowly added and stirred continuously at 0 °C for 30 min. Subsequently, the reaction system was cooled to -60 °C and an ether solution of 2-fluoropyridine (34.0 g, 0.35 mol) was added slowly dropwise and stirring was continued at -60 °C for 1 hour. An ether solution of triisopropoxyborate (82.4 g, 0.44 mol) was added dropwise, then the mixture was gradually warmed to room temperature and stirred for 2 hours. An ether solution of pinacol (55.6 g, 0.47 mol) was added dropwise over 10 minutes, followed by glacial acetic acid (22.1 g, 0.37 mol). The reaction mixture was stirred overnight at room temperature, filtered and the filtrate was extracted with 5% aqueous sodium hydroxide solution. The pH of the aqueous phase was slowly adjusted to 6-7 with 3N hydrochloric acid, ensuring that the temperature was below 5 °C, and then extracted with ethyl acetate. The organic phases were combined and concentrated in vacuum to remove the solvent to afford the target product 2-fluoropyridine-3-boronic acid pinacol ester (27.0 g, 34% yield).
References
[1] Patent: CN103102349, 2017, B. Location in patent: Paragraph 0171-0173
2-FLUOROPYRIDINE-3-BORONIC ACID PINACOL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-FLUOROPYRIDINE-3-BORONIC ACID PINACOL ESTER manufacturers
- Product
- 2-Fluoropyridine-3-boronic acid pinacol ester 452972-14-4
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-07-05
- Product
- 2-Fluoropyridine-3-boronic acid pinacol ester 452972-14-4
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99
- Supply Ability
- 100kg
- Release date
- 2019-07-10