2-Fluoropyridine-5-boronic acid pinacol ester

Product Name: 2-Fluoropyridine-5-boronic acid pinacol ester
CAS No.: 444120-95-0
Chemical Name: 2-Fluoropyridine-5-boronic acid pinacol ester
Synonyms: 2-FLUORO-5-(4 4 5 5-TETRAMETHYL-(1 3 2)&;2-FLUORO-5-(4 4 5 5-TETRAMETHYL-(1 3 2)&2-Flouropyridine-5-boronic acid pinacol ester;2-Fluoro-5-pyridineboronic acid pinacol ester;2-Fluoropyridine-5-boronic acid pinacol ester;2-Fluoropyridin-5-ylboronic acid pinacol ester;6-FLUOROPYRIDINE-3-BORONIC ACID, PINACOL ESTER;2-fluoropyridine-5-borate frequency alcohol ester;2-Fluoropyridine-5-boronic acid pinacol ester >=95%;2-fluorine-5-pyridine borate frequency which ol ester
CBNumber: CB4505189
Molecular Formula: C11H15BFNO2
Formula Weight: 223.05
MOL File: 444120-95-0.mol

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2-Fluoropyridine-5-boronic acid pinacol ester Property

Melting point:: 29-33 °C(lit.)
Boiling point:: 304.2±27.0 °C(Predicted)
Density: 1.09±0.1 g/cm3(Predicted)
Flash point:: >230 °F
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to lump
pka: -0.44±0.12(Predicted)
color: White to Light yellow
InChI: InChI=1S/C11H15BFNO2/c1-10(2)11(3,4)16-12(15-10)8-5-6-9(13)14-7-8/h5-7H,1-4H3
InChIKey: ZKSRQMCKFLGPQU-UHFFFAOYSA-N
SMILES: C1(F)=NC=C(B2OC(C)(C)C(C)(C)O2)C=C1

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 592544
Product name: 2-Fluoropyridine-5-boronic acid pinacol ester
Purity: ≥95%
Packaging: 1g
Price: $230
Updated: 2023/06/20

Sigma-Aldrich

Product number: 592544
Product name: 2-Fluoropyridine-5-boronic acid pinacol ester
Purity: ≥95%
Packaging: 5g
Price: $289
Updated: 2023/06/20

TCI Chemical

Product number: F1094
Product name: 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $84
Updated: 2025/07/31

TCI Chemical

Product number: F1094
Product name: 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $292
Updated: 2025/07/31

TRC

Product number: F596243
Product name: 6-Fluoropyridine-3-boronicacid,pinacolester
Packaging: 1g
Price: $75
Updated: 2021/12/16

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2-Fluoropyridine-5-boronic acid pinacol ester Chemical Properties,Usage,Production

Uses

2-Fluoropyridine-5-boronic acid pinacol ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis

766-11-0

73183-34-3

444120-95-0

General procedure for the synthesis of 2-fluoro-5-bromopyridine and pinacol ester of bisboronic acid from 2-fluoro-5-bromopyridine and pinacol ester of bisboronic acid: under nitrogen protection, Pd(dppf)Cl2 (4.16 g, 5.68 mmol) was added in a single step to a solution containing 5-bromo-2-fluoro-pyridine (10 g, 56.82 mmol), pinacol ester of bisboronic acid (21.64 g, 85.23 mmol) and potassium acetate (16.73 g, 170.46 mmol) in a solution of dioxane (100 mL). The mixture was stirred at room temperature for 10 minutes and then heated to reflux for 6 hours. Upon completion of the reaction, the solvent was removed by direct evaporation and the residue was purified by flash silica gel column chromatography to afford the target product 2-fluoropyridine-5-boronic acid pinacol ester (10.5 g, 82.85% yield). The structure of the product was confirmed by 1H NMR (400 MHz, chloroform-d): δ 8.59 (s, 1H), 8.15 (dt, J = 1.76, 8.41 Hz, 1H), 6.91 (dd, J = 2.26, 8.28 Hz, 1H), 1.35 (s, 12H).

References

[1] Patent: EP3333157, 2018, A1. Location in patent: Paragraph 0255; 0256
[2] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0215
[3] Patent: WO2006/38116, 2006, A2. Location in patent: Page/Page column 40
[4] Patent: EP2891656, 2015, A1. Location in patent: Paragraph 0245
[5] Patent: WO2006/126081, 2006, A2. Location in patent: Page/Page column 52-53

2-Fluoropyridine-5-boronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoropyridine-5-boronic acid pinacol ester Suppliers

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View Lastest Price from 2-Fluoropyridine-5-boronic acid pinacol ester manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Fluoropyridine-5-boronic acid pinacol ester 444120-95-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 97.0%
Supply Ability: 10000KGS
Release date: 2025-05-07

Shaanxi Dideu Medichem Co. Ltd

Product: 2-FLUORO-5-(4 4 5 5-TETRAMETHYL-(1 3 2)& 444120-95-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Fluoropyridine-5-boronic acid pinacol ester 444120-95-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

444120-95-0, 2-Fluoropyridine-5-boronic acid pinacol esterRelated Search:

N-(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide 4-(Boc-aMino)-3-fluorobenzeneboronic acid pinacol ester 2-FLUORO-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 2-Fluoropyridine-5-boronic acid 2-FLUORO-5-(4 4 5 5-TETRAMETHYL-(1 3 2)& 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 2,6-DIFLUORO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]-DIOXABOROLAN-2-YL)PYRIDINE 2-FLUORO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE 3-CHLORO-2-FLUORO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE 5-BROMO-2-FLUORO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]-DIOXABOROLAN-2-YL)PYRIDINE 3-FLUORO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLA,3-FLUORO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE 2,3-DIFLUOROPYRIDINE-5-BORONIC ACID PINACOL ESTER 3-TERT-BUTYLOXYCARBONYLAMINO-2-FLUOROPYRIDINE-5-BORONIC ACID PINACOL ESTER 5-FLUORO-2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-BENZO[B]THIOPHENE 6-FLUORO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-1H-INDAZOLE 3-(2-FLUORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL)PYRIDINE 7-FLUORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)INDOLIN-2-ONE 4-FLUORO-2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

2-Fluoro-5-pyridineboronic acid pinacol ester

2-FLUORO-5-(4 4 5 5-TETRAMETHYL-(1 3 2)&

6-FLUOROPYRIDINE-3-BORONIC ACID, PINACOL ESTER

2-Fluoro-5-pyridineboronic acid pinacol ester, 2-Fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-pyridine

2-Fluoropyridin-5-ylboronic acid pinacol ester

2-Fluoropyridine-5-boronic acid pinacol ester

2-Fluoropyridine-5-boronic acid pinacol ester >=95%

2-Flouropyridine-5-boronic acid pinacol ester

2-fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Pyridine, 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

2-(6-Fluoro-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-FLUORO-5-(4 4 5 5-TETRAMETHYL-(1 3 2)& ISO 9001：2015 REACH

2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyri...

2-FLUORO-5-(4 4 5 5-TETRAMETHYL-(1 3 2)&amp

2-fluorine-5-pyridine borate frequency which ol ester

2-fluoropyridine-5-borate frequency alcohol ester

2-Fluoropyridine-5-boronic acid pinacol ester - [F12465]

444120-95-0

44120-95-0

452972-14-6