ChemicalBook > CAS DataBase List > 2-Fluoropyridine-5-boronic acid pinacol ester

2-Fluoropyridine-5-boronic acid pinacol ester

Product Name
2-Fluoropyridine-5-boronic acid pinacol ester
CAS No.
444120-95-0
Chemical Name
2-Fluoropyridine-5-boronic acid pinacol ester
Synonyms
2-FLUORO-5-(4 4 5 5-TETRAMETHYL-(1 3 2)&;2-FLUORO-5-(4 4 5 5-TETRAMETHYL-(1 3 2)&2-Flouropyridine-5-boronic acid pinacol ester;2-Fluoro-5-pyridineboronic acid pinacol ester;2-Fluoropyridine-5-boronic acid pinacol ester;2-Fluoropyridin-5-ylboronic acid pinacol ester;6-FLUOROPYRIDINE-3-BORONIC ACID, PINACOL ESTER;2-fluoropyridine-5-borate frequency alcohol ester;2-Fluoropyridine-5-boronic acid pinacol ester >=95%;2-fluorine-5-pyridine borate frequency which ol ester
CBNumber
CB4505189
Molecular Formula
C11H15BFNO2
Formula Weight
223.05
MOL File
444120-95-0.mol
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2-Fluoropyridine-5-boronic acid pinacol ester Property

Melting point:
29-33 °C(lit.)
Boiling point:
304.2±27.0 °C(Predicted)
Density 
1.09±0.1 g/cm3(Predicted)
Flash point:
>230 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to lump
pka
-0.44±0.12(Predicted)
color 
White to Light yellow
InChI
InChI=1S/C11H15BFNO2/c1-10(2)11(3,4)16-12(15-10)8-5-6-9(13)14-7-8/h5-7H,1-4H3
InChIKey
ZKSRQMCKFLGPQU-UHFFFAOYSA-N
SMILES
C1(F)=NC=C(B2OC(C)(C)C(C)(C)O2)C=C1
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
592544
Product name
2-Fluoropyridine-5-boronic acid pinacol ester
Purity
≥95%
Packaging
1g
Price
$230
Updated
2023/06/20
Sigma-Aldrich
Product number
592544
Product name
2-Fluoropyridine-5-boronic acid pinacol ester
Purity
≥95%
Packaging
5g
Price
$289
Updated
2023/06/20
TCI Chemical
Product number
F1094
Product name
2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$84
Updated
2025/07/31
TCI Chemical
Product number
F1094
Product name
2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$292
Updated
2025/07/31
TRC
Product number
F596243
Product name
6-Fluoropyridine-3-boronicacid,pinacolester
Packaging
1g
Price
$75
Updated
2021/12/16
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2-Fluoropyridine-5-boronic acid pinacol ester Chemical Properties,Usage,Production

Uses

2-Fluoropyridine-5-boronic acid pinacol ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis

766-11-0

73183-34-3

444120-95-0

General procedure for the synthesis of 2-fluoro-5-bromopyridine and pinacol ester of bisboronic acid from 2-fluoro-5-bromopyridine and pinacol ester of bisboronic acid: under nitrogen protection, Pd(dppf)Cl2 (4.16 g, 5.68 mmol) was added in a single step to a solution containing 5-bromo-2-fluoro-pyridine (10 g, 56.82 mmol), pinacol ester of bisboronic acid (21.64 g, 85.23 mmol) and potassium acetate (16.73 g, 170.46 mmol) in a solution of dioxane (100 mL). The mixture was stirred at room temperature for 10 minutes and then heated to reflux for 6 hours. Upon completion of the reaction, the solvent was removed by direct evaporation and the residue was purified by flash silica gel column chromatography to afford the target product 2-fluoropyridine-5-boronic acid pinacol ester (10.5 g, 82.85% yield). The structure of the product was confirmed by 1H NMR (400 MHz, chloroform-d): δ 8.59 (s, 1H), 8.15 (dt, J = 1.76, 8.41 Hz, 1H), 6.91 (dd, J = 2.26, 8.28 Hz, 1H), 1.35 (s, 12H).

References

[1] Patent: EP3333157, 2018, A1. Location in patent: Paragraph 0255; 0256
[2] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0215
[3] Patent: WO2006/38116, 2006, A2. Location in patent: Page/Page column 40
[4] Patent: EP2891656, 2015, A1. Location in patent: Paragraph 0245
[5] Patent: WO2006/126081, 2006, A2. Location in patent: Page/Page column 52-53

2-Fluoropyridine-5-boronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Fluoropyridine-5-boronic acid pinacol ester manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Fluoropyridine-5-boronic acid pinacol ester 444120-95-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
97.0%
Supply Ability
10000KGS
Release date
2025-05-07
Shaanxi Dideu Medichem Co. Ltd
Product
2-FLUORO-5-(4 4 5 5-TETRAMETHYL-(1 3 2)& 444120-95-0
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26
Henan Aochuang Chemical Co.,Ltd.
Product
2-Fluoropyridine-5-boronic acid pinacol ester 444120-95-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08

444120-95-0, 2-Fluoropyridine-5-boronic acid pinacol esterRelated Search:

N-(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide 4-(Boc-aMino)-3-fluorobenzeneboronic acid pinacol ester 2-FLUORO-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 2-Fluoropyridine-5-boronic acid 2-FLUORO-5-(4 4 5 5-TETRAMETHYL-(1 3 2)& 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 2,6-DIFLUORO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]-DIOXABOROLAN-2-YL)PYRIDINE 2-FLUORO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE 3-CHLORO-2-FLUORO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE 5-BROMO-2-FLUORO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]-DIOXABOROLAN-2-YL)PYRIDINE 3-FLUORO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLA,3-FLUORO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE 2,3-DIFLUOROPYRIDINE-5-BORONIC ACID PINACOL ESTER 3-TERT-BUTYLOXYCARBONYLAMINO-2-FLUOROPYRIDINE-5-BORONIC ACID PINACOL ESTER 5-FLUORO-2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-BENZO[B]THIOPHENE 6-FLUORO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-1H-INDAZOLE 3-(2-FLUORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL)PYRIDINE 7-FLUORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)INDOLIN-2-ONE 4-FLUORO-2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

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