ChemicalBook > CAS DataBase List > Methyl 4,6-dihydroxypyridazine-3-carboxylate

Methyl 4,6-dihydroxypyridazine-3-carboxylate

Product Name
Methyl 4,6-dihydroxypyridazine-3-carboxylate
CAS No.
372118-00-8
Chemical Name
Methyl 4,6-dihydroxypyridazine-3-carboxylate
Synonyms
Methyl 4,6-dihydroxypyridazine-3-carboxylate;methyl 4-hydroxy-6-oxo-1H-pyridazine-3-carboxylate;4,6-dihydroxy-pyridazine-3-carboxylic acid methyl ester;methyl 4-hydroxy-6-oxo-1H-pyridazine-3-carboxylate - [M86609];3-Pyridazinecarboxylic acid, 1,6-dihydro-4-hydroxy-6-oxo-, methyl ester;3-Pyridazinecarboxylicacid,1,6-dihydro-4-hydroxy-6-oxo-,methylester(9CI)
CBNumber
CB91302610
Molecular Formula
C6H6N2O4
Formula Weight
170.12
MOL File
372118-00-8.mol
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Methyl 4,6-dihydroxypyridazine-3-carboxylate Property

Density 
1.58±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
4.50±1.00(Predicted)
Appearance
Light yellow to yellow Solid
InChI
InChI=1S/C6H6N2O4/c1-12-6(11)5-3(9)2-4(10)7-8-5/h2H,1H3,(H2,7,9,10)
InChIKey
SHJHUIKJFYHTDY-UHFFFAOYSA-N
SMILES
C1(C(OC)=O)=NNC(=O)C=C1O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
M507593
Product name
Methyl4,6-dihydroxypyridazine-3-carboxylate
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
M507593
Product name
Methyl4,6-dihydroxypyridazine-3-carboxylate
Packaging
100mg
Price
$240
Updated
2021/12/16
ChemScene
Product number
CS-0106074
Product name
Methyl4,6-dihydroxypyridazine-3-carboxylate
Packaging
250mg
Price
$65
Updated
2021/12/16
ChemScene
Product number
CS-0106074
Product name
Methyl4,6-dihydroxypyridazine-3-carboxylate
Packaging
1g
Price
$197
Updated
2021/12/16
AK Scientific
Product number
4746AB
Product name
Methyl4,6-dihydroxypyridazine-3-carboxylate
Packaging
1g
Price
$440
Updated
2021/12/16
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Methyl 4,6-dihydroxypyridazine-3-carboxylate Chemical Properties,Usage,Production

Synthesis

83878-89-1

372118-00-8

Step 2 Synthesis of methyl 4,6-dihydroxypyridazine-3-carboxylate: dimethyl 2-diazo-3-oxoglutarate (50.0 g, 249.8 mmol) and triphenylphosphine (65.5 g, 249.8 mmol) were dissolved in ethyl ether (500 mL) and stirred at room temperature for 24 hours. After the reaction was completed, the organic solvent was removed under vacuum. Acetic acid (500 mL) and water (50 mL) were added to the residue and the reaction was refluxed for 10 hours. The reaction mixture was concentrated under reduced pressure to give a viscous residue. The residue was ground with ethyl acetate to give a yellow solid. The solid was purified by silica gel column chromatography (100-200 mesh, eluent: dichloromethane solution of 1-5% methanol) to give methyl 4,6-dihydroxypyridazine-3-carboxylate (12.8 g, 30% yield) as a yellow solid.LC-MS: m/z 169.2 [M + H]+.

References

[1] Patent: US2013/178478, 2013, A1. Location in patent: Paragraph 0299;0300
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2683 - 2691
[3] Patent: US2004/77653, 2004, A1. Location in patent: Page 18

Methyl 4,6-dihydroxypyridazine-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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372118-00-8, Methyl 4,6-dihydroxypyridazine-3-carboxylateRelated Search:

Methyl 5,6-dichloropicolinate METHYL-5-BROMOMETHYLPYRIDINE-2-CARBOXYLATE methyl 6-amino-3,5-dibromopicolinate Methyl-5-(bromomethyl)pyrazine-2-carboxylate 6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid Methyl 4,6-dihydroxypyridazine-3-carboxylate 3-Pyridazinecarboxylic acid methyl ester

  • 3-Pyridazinecarboxylicacid,1,6-dihydro-4-hydroxy-6-oxo-,methylester(9CI)
  • Methyl 4,6-dihydroxypyridazine-3-carboxylate
  • 3-Pyridazinecarboxylic acid, 1,6-dihydro-4-hydroxy-6-oxo-, methyl ester
  • methyl 4-hydroxy-6-oxo-1H-pyridazine-3-carboxylate
  • 4,6-dihydroxy-pyridazine-3-carboxylic acid methyl ester
  • methyl 4-hydroxy-6-oxo-1H-pyridazine-3-carboxylate - [M86609]
  • 372118-00-8
  • GLYCINESCAFFOLD