2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
- Product Name
- 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
- CAS No.
- 114289-47-3
- Chemical Name
- 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
- Synonyms
- CI 976;PD 128042;CI-976 (PD 128042);N-(2,4,6-Trimethoxyphenyl)-2,2-dimethyldodecanamide;2,2-DIMETHYL-N-(2,4,6-TRIMETHOXYPHENYL)DODECANAMIDE;2,2-dimethyl-n-(2,4,6-trimethoxyphenyl)-dodecanamid;Dodecanamide, 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-;inhibit,oral,PD128042,PD 128042,CI-976,Diacylglycerol acyltransferase,PD-128042,Acyltransferase,transferase,secretory,LPAT,acyl-CoA:cholesterol acyltransferase,mono- acylglycerol acyltransferase,endocytic membrane trafficking pathway,ACAT,CI976,Diglyceride acyltransferase,Inhibitor
- CBNumber
- CB9130672
- Molecular Formula
- C23H39NO4
- Formula Weight
- 393.56
- MOL File
- 114289-47-3.mol
2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Property
- storage temp.
- 2-8°C
- solubility
- DMSO: >10mg/mL
- form
- solid
- color
- White to off-white
- InChI
- InChI=1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25)
- InChIKey
- WAFNZAURAWBNDZ-UHFFFAOYSA-N
- SMILES
- C(NC1=C(OC)C=C(OC)C=C1OC)(=O)C(C)(C)CCCCCCCCCC
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C3743
- Product name
- CI 976
- Purity
- >98% (HPLC), solid
- Packaging
- 5mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 17235
- Product name
- CI 976
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 17235
- Product name
- CI 976
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $138
- Updated
- 2024/03/01
- Product number
- 17235
- Product name
- CI 976
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $324
- Updated
- 2024/03/01
- Product number
- 17235
- Product name
- CI 976
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $575
- Updated
- 2024/03/01
2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Chemical Properties,Usage,Production
Description
Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT-1) is a sterol O-acyltransferase that catalyzes the formation of fatty acid-cholesterol esters, an important step in lipoprotein assembly and dietary cholesterol absorption. CI-976 is a potent, selective inhibitor of ACAT-1 (IC50 = 73 nM). It is orally bioavailable and decreases plasma total cholesterol, very low density lipoprotein (VLDL) cholesterol, LDL cholesterol, apolipoprotein B, liver cholesteryl esters, and VLDL and LDL cholesteryl ester content in rabbits given a diet that induces hypercholesterolemia. CI-976 also diminishes atherosclerotic activity in hypercholesterolemic rabbits.
Uses
CI 976 has been used as an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor:
- to analyze its anti-hepatitis C virus (HCV) activity in Huh7.5.1 cells
- to treat Neuro-2a cells to test its effect on plasma membrane integrated density of α4-SEPβ2 or α6-SEPβ2β3 nicotinic acetylcholine receptors (nAChRs)
- to study its effects on the anti-angiogenic activity of pyripyropenes in human umbilical vein endothelial cells
Uses
CI-976 (2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide) is a selective inhibitor of Acyl-coenzyme A: cholesterol Acyltransferase 1 (ACAT-1), a sterol O-acetyltransferase that catalyzes information of fatty acid-cholesterol esters. Orally bioavailable and decreses plasma total cholesterol
Definition
ChEBI: 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide is an anilide.
Biological Activity
Selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC 50 = 0.073 μ M). Lowers non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol concentrations in rats with pre-established dyslipidaemia. Orally active.
Biochem/physiol Actions
CI-976 (2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide), a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A; cholesterol acyltransferase (ACAT) in vitro. CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established dyslipidemia. High performance gel chromatographic separation of plasma lipoproteins also revealed that CI-976, but not CL 277,082, lowered low density lipoprotein (LDL)-cholesterol and elevated HDL-cholesterol.
storage
Store at +4°C
2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Preparation Products And Raw materials
Raw materials
Preparation Products
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