2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide

ChemicalBook > CAS DataBase List > 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide

2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide

Product Name: 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
CAS No.: 114289-47-3
Chemical Name: 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
Synonyms: CI 976;PD 128042;CI-976 (PD 128042);N-(2,4,6-Trimethoxyphenyl)-2,2-dimethyldodecanamide;2,2-DIMETHYL-N-(2,4,6-TRIMETHOXYPHENYL)DODECANAMIDE;2,2-dimethyl-n-(2,4,6-trimethoxyphenyl)-dodecanamid;Dodecanamide, 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-;inhibit,oral,PD128042,PD 128042,CI-976,Diacylglycerol acyltransferase,PD-128042,Acyltransferase,transferase,secretory,LPAT,acyl-CoA:cholesterol acyltransferase,mono- acylglycerol acyltransferase,endocytic membrane trafficking pathway,ACAT,CI976,Diglyceride acyltransferase,Inhibitor
CBNumber: CB9130672
Molecular Formula: C23H39NO4
Formula Weight: 393.56
MOL File: 114289-47-3.mol

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2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Property

storage temp.: 2-8°C
solubility: DMSO: >10mg/mL
form: solid
color: White to off-white
InChI: InChI=1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25)
InChIKey: WAFNZAURAWBNDZ-UHFFFAOYSA-N
SMILES: C(NC1=C(OC)C=C(OC)C=C1OC)(=O)C(C)(C)CCCCCCCCCC

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C3743
Product name: CI 976
Purity: >98% (HPLC), solid
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 17235
Product name: CI 976
Purity: ≥95%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 17235
Product name: CI 976
Purity: ≥95%
Packaging: 10mg
Price: $138
Updated: 2024/03/01

Cayman Chemical

Product number: 17235
Product name: CI 976
Purity: ≥95%
Packaging: 25mg
Price: $324
Updated: 2024/03/01

Cayman Chemical

Product number: 17235
Product name: CI 976
Purity: ≥95%
Packaging: 50mg
Price: $575
Updated: 2024/03/01

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2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Chemical Properties,Usage,Production

Description

Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT-1) is a sterol O-acyltransferase that catalyzes the formation of fatty acid-cholesterol esters, an important step in lipoprotein assembly and dietary cholesterol absorption. CI-976 is a potent, selective inhibitor of ACAT-1 (IC₅₀ = 73 nM). It is orally bioavailable and decreases plasma total cholesterol, very low density lipoprotein (VLDL) cholesterol, LDL cholesterol, apolipoprotein B, liver cholesteryl esters, and VLDL and LDL cholesteryl ester content in rabbits given a diet that induces hypercholesterolemia. CI-976 also diminishes atherosclerotic activity in hypercholesterolemic rabbits.

Uses

CI 976 has been used as an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor:

to analyze its anti-hepatitis C virus (HCV) activity in Huh7.5.1 cells
to treat Neuro-2a cells to test its effect on plasma membrane integrated density of α4-SEPβ2 or α6-SEPβ2β3 nicotinic acetylcholine receptors (nAChRs)
to study its effects on the anti-angiogenic activity of pyripyropenes in human umbilical vein endothelial cells

Uses

CI-976 (2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide) is a selective inhibitor of Acyl-coenzyme A: cholesterol Acyltransferase 1 (ACAT-1), a sterol O-acetyltransferase that catalyzes information of fatty acid-cholesterol esters. Orally bioavailable and decreses plasma total cholesterol

Definition

ChEBI: 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide is an anilide.

Biological Activity

Selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC 50 = 0.073 μ M). Lowers non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol concentrations in rats with pre-established dyslipidaemia. Orally active.

Biochem/physiol Actions

CI-976 (2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide), a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A; cholesterol acyltransferase (ACAT) in vitro. CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established dyslipidemia. High performance gel chromatographic separation of plasma lipoproteins also revealed that CI-976, but not CL 277,082, lowered low density lipoprotein (LDL)-cholesterol and elevated HDL-cholesterol.

storage

Store at +4°C

2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Preparation Products And Raw materials

Raw materials

Preparation Products

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114289-47-3, 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamideRelated Search:

Dodecanamide N-(2,6-DIMETHOXYPHENYL)ACETAMIDE 2,4,6-TRIMETHOXYANILINE 2,6-DIMETHOXYANILINE BUTYL-(2,4-DIMETHOXY-PHENYL)-AMINE 3,5-DIMETHOXY-2-AMINO-PHENOL 2,6-DIMETHOXY-N-PROPYLBENZENAMINE 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide

2,2-dimethyl-n-(2,4,6-trimethoxyphenyl)-dodecanamid

2,2-DIMETHYL-N-(2,4,6-TRIMETHOXYPHENYL)DODECANAMIDE

CI 976

PD 128042

N-(2,4,6-Trimethoxyphenyl)-2,2-dimethyldodecanamide

CI-976 (PD 128042)

Dodecanamide, 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-

inhibit,oral,PD128042,PD 128042,CI-976,Diacylglycerol acyltransferase,PD-128042,Acyltransferase,transferase,secretory,LPAT,acyl-CoA:cholesterol acyltransferase,mono- acylglycerol acyltransferase,endocytic membrane trafficking pathway,ACAT,CI976,Diglyceride acyltransferase,Inhibitor

114289-47-3

Miscellaneous Compounds

Selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor.