(-)-EBURNAMONINE
- Product Name
- (-)-EBURNAMONINE
- CAS No.
- 4880-88-0
- Chemical Name
- (-)-EBURNAMONINE
- Synonyms
- vinburnine;VINCAMONE;eburnalritardo;(-)-Vi;ch-846;eburnal;Cervoxan;cis-vincamone;(-)-Vincamone;l-eburnamonine
- CBNumber
- CB9130995
- Molecular Formula
- C19H22N2O
- Formula Weight
- 294.39
- MOL File
- 4880-88-0.mol
(-)-EBURNAMONINE Property
- Melting point:
- 174-177 °C(lit.)
- alpha
- D25 -102° (chloroform) (Clauder); D -100° (c = 0.783 in chloroform) (Cartier)
- Boiling point:
- 436.16°C (rough estimate)
- Density
- 1.34
- refractive index
- 1.5600 (estimate)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly, Heated)
- form
- White to slightly yellow crystalline powder.
- pka
- 8.13±0.40(Predicted)
- color
- White
- Merck
- 13,3520
- LogP
- 3.790 (est)
- CAS DataBase Reference
- 4880-88-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- E320600
- Product name
- (-)-Eburnamonine
- Packaging
- 50mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- E320600
- Product name
- (-)-Eburnamonine
- Packaging
- 1g
- Price
- $720
- Updated
- 2021/12/16
- Product number
- E320600
- Product name
- (-)-Eburnamonine
- Packaging
- 250mg
- Price
- $210
- Updated
- 2021/12/16
- Product number
- FE65898
- Product name
- (-)-Eburnamonine
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- orb573461
- Product name
- (-)-Eburnamonine
- Purity
- >98%
- Packaging
- 1g
- Price
- $2541.5
- Updated
- 2021/12/16
(-)-EBURNAMONINE Chemical Properties,Usage,Production
Chemical Properties
white to slightly yellow crystalline powder
Originator
Euburnamonine ,Shanghai Lansheng Corporation
Uses
(-)-Eburnamonine shows protective effects on mice from the lethal consequences of hypoxia.
Uses
Cerebral vasodilatator
Definition
ChEBI: Eburnamonine is an alkaloid.
Manufacturing Process
200 g (0.087 moles) of cis-1-ethyl-1-(2'-hydroxy-2'-carboxyethyl)-
1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizine were suspended in 100
ml of xylene. 12 g of supported silver carbonate (a silver carbonate-Celite
reagent, containing 50% of silver carbonate) were added to the suspension,
and the system was boiled for 8 hours under a nitrogen atmosphere, with
constant stirring. Thereafter the hot solution was filtered, washed with 3 x 30
ml to 5% sodium carbonate solution, dried over magnesium sulfate, and
evaporated under reduced pressure. 1.05 g of a solid residue, which was a
mixture of racemic vincamone and racemic vincanol, was obtained. 40 ml of
ethyl ether were added to the mixture, and the insoluble crystals were filtered
off. The crystals were recrystallized from methanol, to yield 0.5 g of (+/-)-
eburnamonine (vincamone). Yield: 29.5%. MP: 201°-202°C. The value was
identical with the literature value (J. Mokry et aI.: CoII. Czech, Chem. Comm.
28, 1309, 1963). The etheral mother liquor was processed by preparative
layer chromatography (adsorbent: Kieselgel PF 254+366 , developing agent: a
14:2 mixture of benzene and methanol). The obtained substance was
recrystallized from ether to yield 0.2 g (16%) of (+/-)-vincanol (eburnamine).
MP: 163-164°C, under decomposition. The IR spectrum of the obtained
substance was identical with that of the authentic sample.
Resolution of (+/-)-vincamone:
10.0 g (0.0342 moles) of (+/-)-vincamone and 12.2 g (0.0342 moles) of (-)-
dibenzoyl tartaric acid were dissolved in 150 ml of dichloromethane, the
solution was seeded with crystalline (-)-vincamone-(-)-dibenzoyl-tartarate,
and the mixture was left to stand. The separated crystals were filtered off,
dissolved in dimethylformamide, and the pH of the solution was adjusted to 9 with aqueous ammonia. The separated substance was filtered off, washed with
water, and dried. This way 4.2 g (84%) of (-)-vincamone were obtained; MP:
-176°C; α D 20 = -96°. The mother liquor of resolution was evaporated and (+)-
vincamone was separeted as described above. The obtained substance had
MP: 173°-176°C.; α D 20 = +96°.
Therapeutic Function
Cerebrotonic
(-)-EBURNAMONINE Preparation Products And Raw materials
Raw materials
Preparation Products
(-)-EBURNAMONINE Suppliers
- Tel
- 021-58180488
- Fax
- 021-58180499
- sales@MedChemLeader.com
- Country
- China
- ProdList
- 999
- Advantage
- 58
- Tel
- 021-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6011
- Advantage
- 61
- Tel
- +8618575662672 18575662672
- Fax
- 021 51613951
- mzeng@3wpharm.com
- Country
- China
- ProdList
- 9747
- Advantage
- 57
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 14059
- Advantage
- 65
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9901
- Advantage
- 58
- Tel
- +86 (21) 5811-6473 5811-6475
- Fax
- +86 (21) 6129-4103
- sales@koutingchina.com
- Country
- China
- ProdList
- 496
- Advantage
- 60
- Tel
- 021-58958002 18930822973
- Fax
- +86 (21) 5895-8628
- SALES@UHNSHANGHAI.COM
- Country
- China
- ProdList
- 977
- Advantage
- 58
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4863
- Advantage
- 58
- Tel
- 021-51320588
- Fax
- 0086-21-51320502
- tauto@tautobiotech.com
- Country
- China
- ProdList
- 3989
- Advantage
- 66
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4428
- Advantage
- 55
View Lastest Price from (-)-EBURNAMONINE manufacturers
- Product
- (-)-Eburnamonine 4880-88-0 4880-88-0
- Price
- US $25.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%
- Supply Ability
- 1000.00 kgs
- Release date
- 2019-07-10
- Product
- High purity vinburnine 4880-88-0
- Price
- US $210.00-160.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-03-10
- Product
- (-)-EBURNAMONINE 4880-88-0
- Price
- US $6.60/KG
- Min. Order
- 500g
- Purity
- 98%
- Supply Ability
- 1KG, 50KG, 100KG
- Release date
- 2019-12-25