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pivalyloxymethyl butyrate

Product Name
pivalyloxymethyl butyrate
CAS No.
122110-53-6
Chemical Name
pivalyloxymethyl butyrate
Synonyms
Pivanex;Brn 4861411;Pivanex, 10 mM in DMSO;pivalyloxymethyl butyrate;((2,2-Dimethylpropanoyl)oxy)methyl butanoate;Butanoic acid, (2,2-dimethyl-1-oxopropoxy)methyl ester;Chronic,leukemia,AN 9,muscular,Acute,ALL,atrophy,Inhibitor,lung,Histone deacetylases,NSCLC,myelogenous,lymphoblastic,cancer,HDAC,AN9,CML,Pivanex,spinal,K562,Apoptosis,inhibit,Bcr-Abl
CBNumber
CB91321048
Molecular Formula
C10H18O4
Formula Weight
202.25
MOL File
122110-53-6.mol
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pivalyloxymethyl butyrate Property

Boiling point:
249.3±13.0 °C(Predicted)
Density 
1.008±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: ≥10mg/mL
form 
oil
color 
colorless or slightly yellow
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Safety

WGK Germany 
nwg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H402Harmful to aquatic life

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
A637218
Product name
AN-9
Packaging
1mg
Price
$45
Updated
2021/12/16
TRC
Product number
A637218
Product name
AN-9
Packaging
5mg
Price
$185
Updated
2021/12/16
TRC
Product number
A637218
Product name
AN-9
Packaging
25mg
Price
$865
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0000914
Product name
(PIVALOYLOXY) METHYL BUTYRATE
Purity
95.00%
Packaging
5MG
Price
$633.99
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0000914
Product name
(PIVALOYLOXY) METHYL BUTYRATE
Purity
95.00%
Packaging
25MG
Price
$783.44
Updated
2021/12/16
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pivalyloxymethyl butyrate Chemical Properties,Usage,Production

Uses

AN-9 is an HDAC inhibitor with antimetastic and antiangiogenic properties. Histone deacetylase inhibitors in cancer therapy. Formaldehyde-releasing prodrugs for localized anticancer chemotherapy.

in vivo

Pivanex (AN9, 200 mg/kg, b.i.d, daily) significantly improves the survival of SMN7 SMA mice. Pivanex (AN9) treatment also marked delays the end stage of disease as defined by the onset of body mass loss[3].

Animal Model:SMN7 SMA mice (SMN2+/+; SMN7+/+; mSmn?/?)[3].
Dosage:200 mg/kg.
Administration:Oral administration, b.i.d, at 09.00 and 17.00 daily.
Result:Improved the mean lifespan of treated SMN7 SMA mice by 84.6%.
Delayed the onset of body mass loss in SMN7 SMA mice by 94.9%.

IC 50

HDAC; Bcr-Abl

pivalyloxymethyl butyrate Preparation Products And Raw materials

Raw materials

Preparation Products

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pivalyloxymethyl butyrate Suppliers

Canada 1 China 21 South Korea 1 United States 5 Global 28
Tianjin Derchemist Science & Technology Co., Ltd.
Tel
22-58627059 13920586291
Fax
022-58620305
Email
zdcomcon@126.com
Country
China
ProdList
3829
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50
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
MQ (shanghai) Pharmaceuticals Co., Ltd.
Tel
13761635123
Fax
1014988033@qq
Email
1014988033@qq.com
Country
China
ProdList
4941
Advantage
55
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
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58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
62220
Advantage
58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
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58

122110-53-6, pivalyloxymethyl butyrateRelated Search:

sodium pivalate Neopentyl glycol diacrylate Neopentyl glycol diglycidyl ether 2,2-Dimethyl-1,3-propanediol NEOPENTYLBORONIC ACID Palladium pivalate 97% BENZENESULFONIC ACID NEOPENTYL ESTER Chloromethyl pivalate Cesium 2,2-dimethylpropanoate, Cesium trimethylacetate Neopentylamine PIVMECILLINAM PIVAMPICILLIN Sulbactam pivoxil VALPROATE PIVOXIL 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, [2S-(2alpha,5alpha,6beta)]- pivalyloxymethyl butyrate PIVALOYLOXYMETHYL BUTYRATE, [2-14C] PIVALOYLOXYMETHYL BUTYRATE D-7

  • pivalyloxymethyl butyrate
  • ((2,2-Dimethylpropanoyl)oxy)methyl butanoate
  • Brn 4861411
  • Butanoic acid, (2,2-dimethyl-1-oxopropoxy)methyl ester
  • Pivanex
  • Chronic,leukemia,AN 9,muscular,Acute,ALL,atrophy,Inhibitor,lung,Histone deacetylases,NSCLC,myelogenous,lymphoblastic,cancer,HDAC,AN9,CML,Pivanex,spinal,K562,Apoptosis,inhibit,Bcr-Abl
  • Pivanex, 10 mM in DMSO
  • 122110-53-6