RP 54745
- Product Name
- RP 54745
- CAS No.
- 135330-08-4
- Chemical Name
- RP 54745
- Synonyms
- RP 54745;RP-54745, 10 mM in DMSO;inhibit,RP-54745,RP 54745,Inhibitor,RP54745,Interleukin Related;4-chloro-5-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)dithiol-3-one;4-Chloro-5-(1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)-3H-1,2-dithiol-3-one;3H-1,2-Dithiol-3-one, 4-chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-
- CBNumber
- CB91338303
- Molecular Formula
- C13H12ClNOS2
- Formula Weight
- 297.82
- MOL File
- 135330-08-4.mol
RP 54745 Property
- Boiling point:
- 411.4±55.0 °C(Predicted)
- Density
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO : 62.5 mg/mL (209.86 mM);Water : < 0.1 mg/mL (insoluble)
- pka
- -2.57±0.40(Predicted)
- form
- Solid
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- CS-6750
- Product name
- RP-54745
- Purity
- 99.93%
- Packaging
- 1mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 8982CA
- Product name
- 4-Chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-3H-1,2-dithiol-3-one
- Packaging
- 50mg
- Price
- $205
- Updated
- 2021/12/16
- Product number
- CS-6750
- Product name
- RP-54745
- Purity
- 99.93%
- Packaging
- 5mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 8982CA
- Product name
- 4-Chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-3H-1,2-dithiol-3-one
- Packaging
- 100mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- CS-6750
- Product name
- RP-54745
- Purity
- 99.93%
- Packaging
- 10mg
- Price
- $408
- Updated
- 2021/12/16
RP 54745 Chemical Properties,Usage,Production
Uses
RP-54745 is an inhibitor of macrophage stimulation and interleukin-1 production, and a potential antirheumatic compound.
in vivo
RP-54745 (5 mg/kg) is effective at moderating oral doses in different mouse models of induced arthritis and in the MRL/lpr mice, genetically predisposed to develop an autoimmune pathology including arthritic disorders. The clinical status of the MRL mice, and several of their disturbed biochemical and immunological parameters, improved after a 3-month treatment with RP-54745[2].
IC 50
IL-1
References
[1] Folliard F, et al. RP 54745, a potential antirheumatic compound. I. Inhibitor of macrophage stimulation and interleukin-1 production. Agents Actions. 1992 May;36(1-2):119-26. DOI:10.1007/BF01991239
[2] Folliard F, et al. RP 54745, a potential antirheumatic compound. II. In vivo properties in different animal models. Agents Actions. 1992 May;36(1-2):127-35. DOI:10.1007/BF01991240
RP 54745 Preparation Products And Raw materials
Raw materials
Preparation Products
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