Guan-fu base A
- Product Name
- Guan-fu base A
- CAS No.
- 1394-48-5
- Chemical Name
- Guan-fu base A
- Synonyms
- Guan-fu A;Acehytisine;guan-fu base;Kwan-fu base A;Guan-fu base A;Guan-fu base A USP/EP/BP;(2α,11α,13R)-Hetisan-2,11,13,14-tetrol 2,11-diacetate;Hetisan-2,11,13,14-tetrol,2,13-diacetate, (2a,11a,13R)-;Hetisan-2,11,13,14-tetrol, 2,13-diacetate, (2α,11α,13R)-;(2alpha,11alpha,13R)-Hetisan-2,11,13,14-tetrol 2,13-diacetate
- CBNumber
- CB91341165
- Molecular Formula
- C24H31NO6
- Formula Weight
- 429.51
- MOL File
- 1394-48-5.mol
Guan-fu base A Property
- Boiling point:
- 541.5±50.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, away from moisture and light
- pka
- 12.97±0.70(Predicted)
- form
- Solid
- color
- White to off-white
- InChIKey
- OGNUSOJAYIHLNS-UFZRWAKRNA-N
- SMILES
- O[C@]12[C@@H]([C@]3([H])C(=C)CC41C[C@@]1([H])[C@]5([H])[C@]6(C[C@H](OC(=O)C)C[C@]5([C@]4([H])[C@@H]3O)C2N1C6)C)OC(=O)C |&1:1,2,3,10,12,14,16,22,23,25,r|
N-Bromosuccinimide Price
- Product number
- CBL0000907
- Product name
- GUAN-FU BASE A
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.1
- Updated
- 2021/12/16
- Product number
- SY232803
- Product name
- Guan-fubaseA
- Packaging
- 10mg
- Price
- $381.82
- Updated
- 2021/12/16
- Product number
- 2709
- Product name
- Guan-fu base A
- Packaging
- 5mg
- Price
- $390
- Updated
- 2021/12/16
- Product number
- 2709
- Product name
- Guan-fu base A
- Packaging
- 10mg
- Price
- $590
- Updated
- 2021/12/16
Guan-fu base A Chemical Properties,Usage,Production
Chemical Properties
White crystals, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from the tuberous root of Aconitum carmichaelii (Kanbaifu), a plant of the Ranunculaceae family.
Uses
Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (Ki of 0.38 μM) and dog (Ki of 2.4 μM) microsomes[1]. Guanfu base A also inhibits HERG channel current[2].
in vivo
Beagle dogs treated intravenously with Dextromethorphan (2 mg/mL) after pretreatment with Guanfu base A injection shows reduced CYP2D metabolic activity, with the Cmax of dextrorphan being one-third that of the saline-treated group and area under the plasma concentration-time curve half that of the saline-treated group[1].
References
[1] Sun J, et al. Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms. Drug Metab Dispos. 2015 May;43(5):713-24. DOI:10.1124/dmd.114.060905
[2] Huang X, et al. Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel. J Cardiovasc Pharmacol. 2012 Jan;59(1):77-83. DOI:10.1097/FJC.0b013e318236e380
Guan-fu base A Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Guan-fu base A manufacturers
- Product
- Guan-fu base A 1394-48-5
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-01-02