ChemicalBook > CAS DataBase List > Guan-fu base A

Guan-fu base A

Product Name: Guan-fu base A
CAS No.: 1394-48-5
Chemical Name: Guan-fu base A
Synonyms: Guan-fu A;Acehytisine;guan-fu base;Kwan-fu base A;Guan-fu base A;Guan-fu base A USP/EP/BP;(2α,11α,13R)-Hetisan-2,11,13,14-tetrol 2,11-diacetate;Hetisan-2,11,13,14-tetrol,2,13-diacetate, (2a,11a,13R)-;Hetisan-2,11,13,14-tetrol, 2,13-diacetate, (2α,11α,13R)-;(2alpha,11alpha,13R)-Hetisan-2,11,13,14-tetrol 2,13-diacetate
CBNumber: CB91341165
Molecular Formula: C24H31NO6
Formula Weight: 429.51
MOL File: 1394-48-5.mol

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Guan-fu base A Property

Boiling point:: 541.5±50.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: 4°C, away from moisture and light
pka: 12.97±0.70(Predicted)
form: Solid
color: White to off-white
InChIKey: OGNUSOJAYIHLNS-UFZRWAKRNA-N
SMILES: O[C@]12[C@@H]([C@]3([H])C(=C)CC41C[C@@]1([H])[C@]5([H])[C@]6(C[C@H](OC(=O)C)C[C@]5([C@]4([H])[C@@H]3O)C2N1C6)C)OC(=O)C |&1:1,2,3,10,12,14,16,22,23,25,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CBL0000907
Product name: GUAN-FU BASE A
Purity: 95.00%
Packaging: 5MG
Price: $498.1
Updated: 2021/12/16

Arctom

Product number: SY232803
Product name: Guan-fubaseA
Packaging: 10mg
Price: $381.82
Updated: 2021/12/16

AvaChem

Product number: 2709
Product name: Guan-fu base A
Packaging: 5mg
Price: $390
Updated: 2021/12/16

AvaChem

Product number: 2709
Product name: Guan-fu base A
Packaging: 10mg
Price: $590
Updated: 2021/12/16

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Guan-fu base A Chemical Properties,Usage,Production

Chemical Properties

White crystals, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from the tuberous root of Aconitum carmichaelii (Kanbaifu), a plant of the Ranunculaceae family.

Uses

Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (Ki of 0.38 μM) and dog (Ki of 2.4 μM) microsomes[1]. Guanfu base A also inhibits HERG channel current[2].

in vivo

Beagle dogs treated intravenously with Dextromethorphan (2 mg/mL) after pretreatment with Guanfu base A injection shows reduced CYP2D metabolic activity, with the C_max of dextrorphan being one-third that of the saline-treated group and area under the plasma concentration-time curve half that of the saline-treated group^[1].

References

[1] Sun J, et al. Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms. Drug Metab Dispos. 2015 May;43(5):713-24. DOI:10.1124/dmd.114.060905
[2] Huang X, et al. Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel. J Cardiovasc Pharmacol. 2012 Jan;59(1):77-83. DOI:10.1097/FJC.0b013e318236e380

Guan-fu base A Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Guan-fu base A manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Guan-fu base A 1394-48-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-01-02

1394-48-5, Guan-fu base ARelated Search:

(+)-ISOPULEGOL (S)-2-Isopropylamino-3-methyl-1-butanol 3-AZASPIRO[5.5]UNDECANE TRANS-2-AMINOMETHYL-1-CYCLOHEXANOL Bis(2-ethylhexyl)amine iproheptine Guan-fu base A (-)-DIHYDROCARVEOL 2-METHYL-3-PYRROLIDIN-1-YL-PROPAN-1-OL ISOPULEGYL ACETATE CHEMBRDG-BB 4011223 OCTAHYDRO-2H-QUINOLIZIN-1-YLMETHANOL 4-AZEPAN-1-YL-BUTAN-1-OL 4-DIISOPROPYLAMINO-1-BUTANOL ACETIC ACID CIS-3,3,5-TRIMETHYLCYCLOHEXYL ESTER 3-PYRROLIDINO-1,2-PROPANEDIOL 1,1',3,3'-tetramethyldibutylamine DI-SEC-OCTYLAMINE

Guan-fu base A

(2α,11α,13R)-Hetisan-2,11,13,14-tetrol 2,11-diacetate

(2alpha,11alpha,13R)-Hetisan-2,11,13,14-tetrol 2,13-diacetate

Acehytisine

Kwan-fu base A

Hetisan-2,11,13,14-tetrol, 2,13-diacetate, (2α,11α,13R)-

Hetisan-2,11,13,14-tetrol,2,13-diacetate, (2a,11a,13R)-

Guan-fu base A USP/EP/BP

guan-fu base

Guan-fu A

1394-48-5