Afimoxifene
- Product Name
- Afimoxifene
- CAS No.
- 68392-35-8
- Chemical Name
- Afimoxifene
- Synonyms
- 4-HT;C016601;Alfecifene;AFIMOXIFENE;4-OHT 4-hydroxy;4-Oht hydrotamoxifen;4-Monohydroxytamoxifen;Tamoxifen metabolite B;Afimoxifene cas 68392-35-8;(E/Z)-4-Hydroxy Tamoxifen
- CBNumber
- CB91353793
- Molecular Formula
- C26H29NO2
- Formula Weight
- 387.51
- MOL File
- 68392-35-8.mol
Afimoxifene Property
- Melting point:
- 135-144°C
- Boiling point:
- 514.4±50.0 °C(Predicted)
- Density
- 1.092
- storage temp.
- 2-8°C
- solubility
- methanol: soluble10mg/mL
- form
- solution
- pka
- 9.38±0.15(Predicted)
- color
- white to off-white
Safety
- Hazard Codes
- Xn
- Risk Statements
- 63-20/21/22
- Safety Statements
- 22-23-36
- RIDADR
- UN1170 - class 3 - PG 2 - Ethanol, solution
- WGK Germany
- 3
- RTECS
- SL1210000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- H6278
- Product name
- 4-Hydroxytamoxifen
- Purity
- ≥70% Z isomer (remainder primarily E-isomer)
- Packaging
- 10mg
- Price
- $95.3
- Updated
- 2024/03/01
- Product number
- 94873
- Product name
- 4-Hydroxytamoxifen
- Purity
- (
- Packaging
- 10mg
- Price
- $218
- Updated
- 2024/03/01
- Product number
- 17308
- Product name
- (E/Z)-4-hydroxy Tamoxifen
- Purity
- ≥98% (E) and (Z) isomers (50:50)
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 17308
- Product name
- (E/Z)-4-hydroxy Tamoxifen
- Purity
- ≥98% (E) and (Z) isomers (50:50)
- Packaging
- 10mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- T176
- Product name
- 4-Hydroxytamoxifen
- Purity
- analytical standard, (
- Packaging
- 10mg
- Price
- $88.8
- Updated
- 2024/03/01
Afimoxifene Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
A selective estrogen receptor modulator.
Uses
(E/Z)-4-Hydroxy Tamoxifen is selective estrogen receptor modulator.
Definition
ChEBI: Afimoxifene is a tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen. It has a role as an antineoplastic agent, an estrogen receptor antagonist and a metabolite. It is a tertiary amino compound and a member of phenols. It is functionally related to a tamoxifen.
brand name
TamoGel (Ascend Therapeutics).
General Description
4-Hydroxytamoxifen is a first generation, selective estrogen receptor modulator (SERM) that functions as an antagonist in breast cancer cells but can display estrogen-like activities in the uterus and bone.
Biological Activity
4-hydroxytamoxifen is an estrogen receptor modulator.estrogen receptor can be selectively stimulated or inhibited, providing promising therapeutic opportunities for auto-immune diseases, prostate and breast cancer, as well as depression.
Biochem/physiol Actions
Metabolite of the chemotherapeutic drug tamoxifen, exhibiting more potent estrogen agonist/antagonist activity than the parent drug. Also active as intra-membranous inhibitor of lipid peroxidation.
in vitro
previous study was conducted to evaluate the effects of tamoxifen and its active metabolite 4-hydroxytamoxifen on isolated rat cardiac myocyte mechanical function and calcium handling. results showed that myocytes treated with 4-hydroxytamoxifen had similarly to tamoxifen-treated cells to both calcium handling and contractility [1].
in vivo
previous animal study compared the extent of dna adduct formation in sd rats treated with seven tamoxifen or 4-hydroxytamoxifen. results showed that the liver weights and microsomal rates were not changed by tamoxifen or 4-hydroxytamoxifen treatment. moreover, the uterine weights were significantly decreased and uterine peroxidase activity was marginally decreased in tamoxifen or 4-hydroxytamoxifen treated rats. in addition, hepatic dna adduct levels in rats treated with 4-hydroxytamoxifen did not differ from control rats. similaryly, the adduct levels in uterus dna from rats treated with tamoxifen or 4-hydroxytamoxifen were not different from those in control rats [2].
IC 50
27 and 18 μm for mcf-7 and mda-mb-231 cell proliferation
storage
-20°C
References
[1] asp ml,martindale jj,metzger jm. direct, differential effects of tamoxifen, 4-hydroxytamoxifen, and raloxifene on cardiac myocyte contractility and calcium handling. plos one.2013 oct 24;8(10):e78768.
[2] beland fa,mcdaniel lp,marques mm. comparison of the dna adducts formed by tamoxifen and 4-hydroxytamoxifen in vivo. carcinogenesis.1999 mar;20(3):471-7.
[3] lee o et al. a randomized phase ii presurgical trial of transdermal 4-hydroxytamoxifen gel versus oral tamoxifen in women with ductal carcinoma in situ of the breast. clin cancer res.2014 jul 15;20(14):3672-82.
Afimoxifene Preparation Products And Raw materials
Raw materials
Preparation Products
Afimoxifene Suppliers
- Tel
- 13522905323
- sales@hxybio.com
- Country
- China
- ProdList
- 339
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6011
- Advantage
- 61
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 18089
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32344
- Advantage
- 50
- Tel
- 0086-21-67651709
- Fax
- 0086-21-67651705
- cfx759@hotmail.com
- Country
- China
- ProdList
- 410
- Advantage
- 57
- Tel
- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
- Fax
- +86-27-87599188
- Country
- China
- ProdList
- 1494
- Advantage
- 55
- Tel
- +862136680027 15800370750
- sales@famobiotech.com
- Country
- China
- ProdList
- 509
- Advantage
- 56
- Tel
- 18521735133 18521732826;
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25014
- Advantage
- 65
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4428
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7854
- Advantage
- 58
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3422
- Advantage
- 58
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9636
- Advantage
- 58
- Tel
- +86-571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 10015
- Advantage
- 53
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2989
- Advantage
- 60
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51471
- Advantage
- 80
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4153
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9709
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 27322
- Advantage
- 60
- Tel
- 17754423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8011
- Advantage
- 62
- Tel
- 21-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2990
- Advantage
- 58
- Tel
- QQ:65489617 15618227136
- Fax
- 21-5161 9052
- info@SuperLan-chem.com
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29797
- Advantage
- 68
- Tel
- 0371-55900031 18137872243
- Fax
- QQ：2853979815
- 2853979815@qq.com
- Country
- China
- ProdList
- 10021
- Advantage
- 55
- Tel
- 021-58180488
- Fax
- 021-58180499
- sales@MedChemLeader.com
- Country
- China
- ProdList
- 999
- Advantage
- 58
- Tel
- 86-0573-85866609 13325730825
- Fax
- 0573-85866609
- 945717149@qq.com
- Country
- China
- ProdList
- 7959
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 15085
- Advantage
- 58
- Tel
- 021-60345187 13917602471
- Fax
- 021-60345187
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 9908
- Advantage
- 58
- Tel
- 17317130613
- Fax
- QQ3358272972
- 3358272972@qq.com
- Country
- China
- ProdList
- 3242
- Advantage
- 58
- Tel
- 010-010-62971590 18548936886
- Fax
- 010-62340519
- 3462612863@qq.com
- Country
- China
- ProdList
- 6912
- Advantage
- 58
- Tel
- 029-87576359 17691182729
- Fax
- 029-88380327
- 1018@dideu.com
- Country
- China
- ProdList
- 1985
- Advantage
- 58
- Tel
- +86-400-002-6226 13028896684
- sales@rrkchem.com
- Country
- China
- ProdList
- 55896
- Advantage
- 58
- Tel
- 020-31155029 18902330969
- Fax
- 020-31155029
- sales@tomums.cn
- Country
- China
- ProdList
- 4698
- Advantage
- 58
- Tel
- +86-27-87465837 +8618971612321
- Fax
- 86 27 87772287
- info@finetechnology-ind.com
- Country
- China
- ProdList
- 9635
- Advantage
- 58
- Tel
- 029-89275612 +8618991951683
- Fax
- 8618991951683
- mcbio_sales@163.com
- Country
- China
- ProdList
- 2255
- Advantage
- 58
- Tel
- 17825480238
- Fax
- QQ 3008233717
- 3008233717@qq.com
- Country
- China
- ProdList
- 9843
- Advantage
- 12
- Tel
- 15021845385
- 765325601@qq.com
- Country
- China
- ProdList
- 3611
- Advantage
- 58
- Tel
- 18871490254
- Fax
- 027-59599243
- linda@hubeijusheng.com
- Country
- CHINA
- ProdList
- 28180
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9414
- Advantage
- 58
- Tel
- 021-13773155751 19901447308
- 260924549@qq.com
- Country
- China
- ProdList
- 8709
- Advantage
- 58
- Tel
- 13361936468
- 410756539@qq.com
- Country
- China
- ProdList
- 305
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11289
- Advantage
- 58
- Tel
- +8618523575427
- sales@conier.com
- Country
- China
- ProdList
- 49391
- Advantage
- 58
- Tel
- +86-0371-86658258 15093356674;
- Fax
- 0086-371-86658258
- factory@coreychem.com
- Country
- China
- ProdList
- 29826
- Advantage
- 58
- Tel
- 020-020-82000279 18988968278
- Fax
- QQ：3283937693
- sales@ubiochem.com
- Country
- China
- ProdList
- 2414
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- chenjw@absin.cn
- Country
- China
- ProdList
- 24734
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 021-51111890 15317326293
- sales@molnova.com
- Country
- China
- ProdList
- 4196
- Advantage
- 58
- Tel
- 13522808617
- omiget@qq.com
- Country
- China
- ProdList
- 9213
- Advantage
- 58
- Tel
- 650-6922368
- sales@achemblock.com
- Country
- China
- ProdList
- 2992
- Advantage
- 58
View Lastest Price from Afimoxifene manufacturers
- Product
- Afimoxifene 68392-35-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%-99.9%HPLC
- Supply Ability
- 100KG
- Release date
- 2020-02-04