LEUPEPTIN HEMISULFATE MONOHYDRATE

Product Name: LEUPEPTIN HEMISULFATE MONOHYDRATE
CAS No.: 55123-66-5
Chemical Name: LEUPEPTIN HEMISULFATE MONOHYDRATE
Synonyms: Gentibiose;methyl-(s)-;l-valeramide;β-Gentiobiose,β-form;Leupeptin (0.5 mg vial);AC-LEU-LEU-ARGINAL 1/2H2SO4 H2O;LEUPEPTIN HEMISULFATE MONOHYDRATE;Ac-Leu-Leu-Arg-aldehyde . sulfate;6-O-?D-Glucopyranosyl-D-glucopyranose;6-O-B-D-GLUCOPYRANOSYL-D-GLUCOPYRANOSE
CBNumber: CB9135839
Molecular Formula: C20H38N6O4
Formula Weight: 426.55
MOL File: 55123-66-5.mol

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LEUPEPTIN HEMISULFATE MONOHYDRATE Property

Boiling point:: 541.98°C (rough estimate)
Density: 1.1865 (rough estimate)
refractive index: 1.6000 (estimate)
RTECS: YV4205100
pka: 13.44±0.46(Predicted)
form: Powder

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P405Store locked up.

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N-Bromosuccinimide Price

Chem-Impex

Product number: 32802
Product name: Leupeptin
Packaging: 5MG
Price: $64.06
Updated: 2021/12/16

Chem-Impex

Product number: 32802
Product name: Leupeptin
Packaging: 25MG
Price: $180.54
Updated: 2021/12/16

Chem-Impex

Product number: 32802
Product name: Leupeptin
Packaging: 100MG
Price: $524.16
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000260
Product name: LEUPEPTIN HEMISULFATE
Purity: 95.00%
Packaging: 25MG
Price: $830.74
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000260
Product name: LEUPEPTIN HEMISULFATE
Purity: 95.00%
Packaging: 50MG
Price: $975.45
Updated: 2021/12/16

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LEUPEPTIN HEMISULFATE MONOHYDRATE Chemical Properties,Usage,Production

Uses

Leupeptin is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin potently inhibits serine, cysteine and threonine proteases. Leupeptin inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity[1][2][3].

Definition

ChEBI: Leupeptin is a tripeptide composed of N-acetylleucyl, leucyl and argininal residues joined in sequenceby peptide linkages. It is an inhibitor of the calpains, a family of calcium-activated proteases which promote cell death. It has a role as a serine protease inhibitor, a bacterial metabolite, a cathepsin B inhibitor, a calpain inhibitor and an EC 3.4.21.4 (trypsin) inhibitor. It is a tripeptide and an aldehyde. It is a conjugate base of a leupeptin(1+).

Safety Profile

Questionable carcinogen withexperimental neoplastigenic data. When heated todecomposition it emits toxic fumes of NOx.

in vivo

Leupeptin (0, 9, 18, 36 mg/kg; i.p.; single) is well tolerated by the animals and produces a strong, dose-dependent increase in LC3b-II in both the total tissue extracts and the lysosome and autophagosome-enriched pellet fraction^[2].

Animal Model:	C57BL/6NCrl male mice (6-8 weeks old, 20-25 g)^[1].
Dosage:	0, 9, 18, 36 mg/kg
Administration:	Intraperitoneal injection; single
Result:	Promoted the accumulation of LC3b-II in mouse liver.

References

[1] Aoyagi T, et al. Biological activities of leupeptins. J Antibiot (Tokyo). 1969 Nov;22(11):558-68. DOI:10.7164/antibiotics.22.558
[2] Fu L, et al. Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs. mBio. 2021 Oct 26;12(5):e0222021. DOI:10.1128/mBio.02220-21
[3] Haspel J, et al. Characterization of macroautophagic flux in vivo using a leupeptin-based assay. Autophagy. 2011 Jun;7(6):629-42. DOI:10.4161/auto.7.6.15100
[4] Aoyagi T, et al. Biological activities of leupeptins. J Antibiot (Tokyo). 1969 Nov;22(11):558-68.

LEUPEPTIN HEMISULFATE MONOHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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55123-66-5, LEUPEPTIN HEMISULFATE MONOHYDRATERelated Search:

N-ETHYLGUANIDINIUM SULFATE (S)-Propane-1,2-diamine sulfate ETHYLENEDIAMINE SULFATE Mafenide hydrochloride Milacemide 1-METHYLGUANIDINE SULFATE H-LEU-NH2 Agmatine sulfate Guanidine sulfate Leupeptin LEUPEPTIN AC-GLY-LEU-NH2 PROPIONYL-LEU-LEU-ARG-AL HEMISULFATE AC-LEU-NHME AC-LEU-NH2 N-ACETYLPUTRESCINE HYDROCHLORIDE LEUPEPTIN HEMISULFATE MONOHYDRATE N-(2-aminoethyl)butane-1,4-diamine

(s)-2-(2-acetamido-4-methylvaleramido)-n-(1-formyl-4-guanidinobutyl)-4-methy

l-valeramide

methyl-(s)-

LEUPEPTIN HEMISULFATE MONOHYDRATE

6-O-B-D-GLUCOPYRANOSYL-D-GLUCOPYRANOSE

Ac-Leu-Leu-Arg-aldehyde . sulfate

Gentibiose

(2S)-2-[(Ac-Leu-Leu-)Amino]-5-guanidinopentanal

(2S)-5-Guanidino-2-[[N-(N-acetyl-L-leucyl)-L-leucyl]amino]pentanal

(S)-2-[(N-Acetyl-L-Leu-L-Leu-)amino]-5-guanidinopentanal

(2S)-2-[[(2S)-2-acetamido-4-methyl-pentanoyl]amino]-N-[(1S)-1-formyl-4-guanidino-butyl]-4-methyl-valeramide

(2S)-2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-N-[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-methylpentanamide

ACETYL-L-LEUCYL-L-LEUCYL-L-ARGININAL HEMISULFATE MONOHYDRATE

AC-LEU-LEU-ARGINAL 1/2H2SO4 H2O

6-O-?D-Glucopyranosyl-D-glucopyranose

(2S)-2-[[(2S)-2-acetamido-4-methyl-pentanoyl]amino]-N-[(2S)-5-[bis(azanyl)methylideneamino]-1-oxo-pentan-2-yl]-4-methyl-pentanamide

Ac-Leu-Leu-Arg-aldehyde · sulfate salt

β-Gentiobiose,β-form

L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-formylbutyl]-

Leupeptin (0.5 mg vial)

Leupeptin hemisulphate salt monohydrate (Synthetic)

55123-66-5

2C20H38N6O42H2OH2O4SS

Antibiotics