5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE

Product Name: 5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE
CAS No.: 6508-43-6
Chemical Name: 5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE
Synonyms: L-152,804;9-(4,4-Dimethyl-2,6-dioxocyclohexyl)-1,2,3,4-tetrahydro-3,3-dimethyl-1-xanthenone;5,5-Mmethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1-oxo-1H-xanthen-9-yl)-1,3 cyclohexanedione;5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE;2-(3,3-Dimethyl-1-oxo-2,3,4,9-tetrahydro-1H-xanthen-9-yl)-5,5-dimethylcyclohexane-1,3-dione;1,3-Cyclohexanedione, 5,5-dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1-oxo-1H-xanthen-9-yl)-
CBNumber: CB9136715
Molecular Formula: C23H26O4
Formula Weight: 366.45
MOL File: 6508-43-6.mol

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5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE Property

Melting point:: 207-208 °C
Boiling point:: 513.7±50.0 °C(Predicted)
Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: Desiccate at +4°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
form: powder
pka: 4.86±0.42(Predicted)
color: white to beige

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Safety

Hazard Codes: T,N
Risk Statements: 25-50/53
Safety Statements: 45-60-61
RIDADR: UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0891
Product name: L-152,804
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $105
Updated: 2022/05/15

Tocris

Product number: 1382
Product name: L-152,804
Purity: ≥99%(HPLC)
Packaging: 10
Price: $225
Updated: 2021/12/16

Tocris

Product number: 1382
Product name: L-152,804
Purity: ≥99%(HPLC)
Packaging: 50
Price: $927
Updated: 2021/12/16

Usbiological

Product number: 255625
Product name: L-152,804
Packaging: 10mg
Price: $480
Updated: 2021/12/16

Usbiological

Product number: 453113
Product name: L-152,804
Packaging: 1mg
Price: $368
Updated: 2021/12/16

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5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE Chemical Properties,Usage,Production

Uses

L-152,804 is a potent and orally available Y5 antagonist, which is the receptor postulated to be responsible for hypothalamic "feeding".

Definition

ChEBI: 2-(3,3-dimethyl-1-oxo-4,9-dihydro-2H-xanthen-9-yl)-5,5-dimethylcyclohexane-1,3-dione is a member of xanthenes.

Biological Activity

Potent, selective non-peptide neuropeptide Y Y 5 receptor antagonist (K i = 26 nM for hY 5 ). Displays > 300-fold selectivity over hY 1 , hY 2 , and hY 4 receptors. Causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Centrally active upon oral administration in vivo .

storage

Desiccate at +4°C

5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE Preparation Products And Raw materials

Raw materials

Preparation Products

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5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE Suppliers

China 20 Europe 1 Germany 2 United Kingdom 1 United States 7 Global 31

3B Pharmachem (Wuhan) International Co.,Ltd.

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Tianjin Kailiqi Biotechnology Co., Ltd.

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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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ShangHai ChuanQian Chemcial Technique Centre

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Beijing Jin Ming Biotechnology Co., Ltd.

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Shanghai Universal Biotech Co.,Ltd

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Bide Pharmatech Ltd.

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6508-43-6, 5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONERelated Search:

Dimedone 3-N-PENTYL-2,4-PENTANEDIONE 2-Methyl-1,3-cyclohexanedione 3-N-BUTYL-2,4-PENTANEDIONE 2-BENZYLCYCLOHEXANONE 2-ALLYLCYCLOHEXANE-1,3-DIONE 2,4-Pentandedione, 3-(phenylmethyl) 3-(1-PHENYL-ETHYL)-PENTANE-2,4-DIONE 3-BENZYL-4-HEPTANONE (+)-MENTHONE 3-acetylheptane-2,6-dione 5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE 1-METHOXY-5-METHYL-HEX-1-EN-3-ONE 2,5-DIMETHYLCYCLOHEXANE-1,3-DIONE 6-PHENOXY-HEXAN-2-ONE 5,5-dimethyl-2-prop-2-enyl-cyclohexane-1,3-dione 3-METHYLENE-2,6-HEPTANEDIONE, TECH. 85

5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE

L-152,804

5,5-Mmethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1-oxo-1H-xanthen-9-yl)-1,3 cyclohexanedione

9-(4,4-Dimethyl-2,6-dioxocyclohexyl)-1,2,3,4-tetrahydro-3,3-dimethyl-1-xanthenone

1,3-Cyclohexanedione, 5,5-dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1-oxo-1H-xanthen-9-yl)-

2-(3,3-Dimethyl-1-oxo-2,3,4,9-tetrahydro-1H-xanthen-9-yl)-5,5-dimethylcyclohexane-1,3-dione

6508-43-6

C23H26O4

Neuropeptide Y (NPY ) receptor