ChemicalBook > CAS DataBase List > 5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE

5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE

Product Name
5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE
CAS No.
6508-43-6
Chemical Name
5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE
Synonyms
L-152,804;L 152804, 10 mM in DMSO;9-(4,4-Dimethyl-2,6-dioxocyclohexyl)-1,2,3,4-tetrahydro-3,3-dimethyl-1-xanthenone;5,5-Mmethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1-oxo-1H-xanthen-9-yl)-1,3 cyclohexanedione;5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE;2-(3,3-Dimethyl-1-oxo-2,3,4,9-tetrahydro-1H-xanthen-9-yl)-5,5-dimethylcyclohexane-1,3-dione;1,3-Cyclohexanedione, 5,5-dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1-oxo-1H-xanthen-9-yl)-
CBNumber
CB9136715
Molecular Formula
C23H26O4
Formula Weight
366.45
MOL File
6508-43-6.mol
More
Less

5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE Property

Melting point:
207-208 °C
Boiling point:
513.7±50.0 °C(Predicted)
Density 
1.20±0.1 g/cm3(Predicted)
storage temp. 
Desiccate at +4°C
solubility 
DMSO: soluble5mg/mL, clear (warmed)
form 
powder
pka
4.86±0.42(Predicted)
color 
white to beige
More
Less

Safety

Hazard Codes 
T,N
Risk Statements 
25-50/53
Safety Statements 
45-60-61
RIDADR 
UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0891
Product name
L-152,804
Purity
≥98% (HPLC)
Packaging
5mg
Price
$105
Updated
2022/05/15
Tocris
Product number
1382
Product name
L-152,804
Purity
≥99%(HPLC)
Packaging
10
Price
$225
Updated
2021/12/16
Tocris
Product number
1382
Product name
L-152,804
Purity
≥99%(HPLC)
Packaging
50
Price
$927
Updated
2021/12/16
Usbiological
Product number
255625
Product name
L-152,804
Packaging
10mg
Price
$480
Updated
2021/12/16
Usbiological
Product number
453113
Product name
L-152,804
Packaging
1mg
Price
$368
Updated
2021/12/16
More
Less

5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE Chemical Properties,Usage,Production

Uses

L-152,804 is a potent and orally available Y5 antagonist, which is the receptor postulated to be responsible for hypothalamic "feeding".

Definition

ChEBI: 2-(3,3-dimethyl-1-oxo-4,9-dihydro-2H-xanthen-9-yl)-5,5-dimethylcyclohexane-1,3-dione is a member of xanthenes.

Biological Activity

Potent, selective non-peptide neuropeptide Y Y 5 receptor antagonist (K i = 26 nM for hY 5 ). Displays > 300-fold selectivity over hY 1 , hY 2 , and hY 4 receptors. Causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Centrally active upon oral administration in vivo .

IC 50

NPY Y5 receptor

storage

Desiccate at +4°C

5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE Suppliers

China 35 Europe 1 Germany 2 United Kingdom 1 United States 7 Global 46
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4989
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
Shanghai Universal Biotech Co.,Ltd
Tel
15921930842 15921930842
Email
yh-wang@univ-bio.com
Country
China
ProdList
25004
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
Kaifeng Mingren Pharmaceutical Co.,LTD
Tel
0371-65741762
Fax
QQ：2860768577
Email
sales@hasunny.com
Country
China
ProdList
2380
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
400-6206333 13167063860
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
48457
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd
Tel
025-58851090 17714375163
Email
2881759498@qq.com
Country
China
ProdList
13011
Advantage
58
R&D Systems, Inc
Tel
18003437475
Fax
1-612-656-4400
Email
rdname@qq.com
Country
China
ProdList
6960
Advantage
58
Sangon Biotech (Shanghai) Co.,Ltd.
Tel
400-821-026
Email
Sales@sangon.com
Country
China
ProdList
6710
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Adooq Bioscience LLC
Tel
400-025-6535
Email
sales@adooq.cn
Country
China
ProdList
6215
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
Guangzhou Jingyan Biotechnology Co., Ltd.
Tel
13822277471
Country
CHINA
ProdList
187
Advantage
58
Guangzhou Weisheng Biotechnology Co., Ltd.
Tel
17765667235
Country
CHINA
ProdList
129
Advantage
58
Guangzhou Tuoshan Biotechnology Co., Ltd.
Tel
19928332050
Country
CHINA
ProdList
161
Advantage
58
Guangzhou Kati Biotechnology Co., Ltd.
Tel
13128698830
Country
CHINA
ProdList
199
Advantage
58
Guangzhou Squirrel Biotechnology Co., Ltd.
Tel
17765276361
Country
CHINA
ProdList
109
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Proteintech China
Tel
--
Fax
--
Email
Proteintech-CN@ptglab.com
Country
CHINA
ProdList
6290
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Xiamen Huijia Biological Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6973
Advantage
58
Shanghai Weiwei Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
sales@wheybio.com
Country
CHINA
ProdList
4398
Advantage
58
Beijing Baiao Innovation Technology Co., Ltd.
Tel
--
Fax
--
Email
3007606172@qq.com
Country
CHINA
ProdList
6002
Advantage
58
Shanghai Haoyang Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
596799915@QQ.COM
Country
CHINA
ProdList
2905
Advantage
58
Shanghai Chaoyan Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
471161314@qq.com
Country
CHINA
ProdList
6210
Advantage
58
Beijing Bolide Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1985563437@qq.com
Country
CHINA
ProdList
6525
Advantage
58
Shanghai Yuda Industrial Co., Ltd.
Tel
--
Fax
--
Email
lucy@runwelltac.com
Country
CHINA
ProdList
6448
Advantage
58
Beijing Taize Ruida Technology Co., Ltd.
Tel
--
Fax
--
Email
taizeorder@163.com
Country
CHINA
ProdList
6536
Advantage
58

6508-43-6, 5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONERelated Search:

Dimedone 3-N-PENTYL-2,4-PENTANEDIONE 2-Methyl-1,3-cyclohexanedione 3-N-BUTYL-2,4-PENTANEDIONE 2-BENZYLCYCLOHEXANONE 2-ALLYLCYCLOHEXANE-1,3-DIONE 2,4-Pentandedione, 3-(phenylmethyl) 3-(1-PHENYL-ETHYL)-PENTANE-2,4-DIONE 3-BENZYL-4-HEPTANONE (+)-MENTHONE 3-acetylheptane-2,6-dione 5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE 1-METHOXY-5-METHYL-HEX-1-EN-3-ONE 2,5-DIMETHYLCYCLOHEXANE-1,3-DIONE 6-PHENOXY-HEXAN-2-ONE 5,5-dimethyl-2-prop-2-enyl-cyclohexane-1,3-dione 3-METHYLENE-2,6-HEPTANEDIONE, TECH. 85

  • 5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1OXO-1H-XANTHEN-9-YL)-1,3-CYCLOHEXANEDIONE
  • L-152,804
  • 5,5-Mmethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1-oxo-1H-xanthen-9-yl)-1,3 cyclohexanedione
  • 9-(4,4-Dimethyl-2,6-dioxocyclohexyl)-1,2,3,4-tetrahydro-3,3-dimethyl-1-xanthenone
  • 1,3-Cyclohexanedione, 5,5-dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1-oxo-1H-xanthen-9-yl)-
  • 2-(3,3-Dimethyl-1-oxo-2,3,4,9-tetrahydro-1H-xanthen-9-yl)-5,5-dimethylcyclohexane-1,3-dione
  • L 152804, 10 mM in DMSO
  • 6508-43-6
  • C23H26O4
  • Neuropeptide Y (NPY ) receptor