Methotrexate disodium salt

Product Name: Methotrexate disodium salt
CAS No.: 7413-34-5
Chemical Name: Methotrexate disodium salt
Synonyms: mtxdisodium;METHOTREXATUM;l-(+)-isodiumsal;amethopterinsodium;sodium methotrexate;disodiummethotrexate;METHOTREXATE DISODIUM;Methotrexatedisodiumsal;METHOTREXATE DISODIUM SALT;D3-Methotrexate Disodium Salt
CBNumber: CB9136836
Molecular Formula: C20H23N8NaO5
Formula Weight: 478.44
MOL File: 7413-34-5.mol

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Methotrexate disodium salt Property

Boiling point:: 823℃
RTECS: MA1232000
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: DMSO (Slightly), Water (Slightly)
form: Powder
color: Light yellow to yellow
Water Solubility: Soluble in water
Sensitive: Hygroscopic
InChIKey: MSDCZRQHAGWZSH-NVZXTOETNA-N
SMILES: NC1=NC(N)=NC2N=CC(CN(C3C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=3)C)=NC1=2.[NaH] |&1:19,r|

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Safety

HazardClass: 6.1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P321Specific treatment (see … on this label).

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3779
Product name: Methotrexate disodium salt
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $81.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3779
Product name: Methotrexate disodium salt
Purity: ≥98% (HPLC)
Packaging: 250mg
Price: $328
Updated: 2025/07/31

TRC

Product number: M260753
Product name: MethotrexateDisodiumSalt
Packaging: 25mg
Price: $50
Updated: 2021/12/16

TRC

Product number: M260753
Product name: MethotrexateDisodiumSalt
Packaging: 50mg
Price: $70
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007714
Product name: METHOTREXATE DISODIUM SALT
Purity: 95.00%
Packaging: 1G
Price: $1024.78
Updated: 2021/12/16

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Methotrexate disodium salt Chemical Properties,Usage,Production

Uses

Inhibits the metabolism of folic acid

Definition

ChEBI: Methotrexate disodium is an organic sodium salt that is the disodium salt of methotrexate. It has a role as an EC 1.5.1.3 (dihydrofolate reductase) inhibitor. It contains a methotrexate(2-).

Biological Activity

Methotrexate disodium salt is a potent is a folic acid antagonist th at is used as an antineoplastic and antirheumatic drug. Methotrexate disodium salt is a potent inhibitor of dihydrofolate reductase.

in vivo

Methotrexate (Amethopterin) disodium reduces thymus and spleen indices of mice. Methotrexate disodium markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice^[2].
Methotrexate (MTX) disodium (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate disodium (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity^[4].

IC 50

Traditional Cytotoxic Agents

Methotrexate disodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Methotrexate disodium salt Suppliers

China 219 Finland 2 Germany 1 India 3 Japan 2 United States 12 Global 239

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Energy Chemical

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View Lastest Price from Methotrexate disodium salt manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Methotrexate disodium salt 7413-34-5
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98.5%min
Supply Ability: 300/month
Release date: 2021-06-03

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Methotrexate disodium salt 7413-34-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-04-16

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Methotrexate Disodium 7413-34-5
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-08-05

7413-34-5, Methotrexate disodium saltRelated Search:

Methotrexate IMpurity C Pemetrexed Disodium 1,1,3-Tribromoacetone Etoposide Methotrexate METHOTREXATE, DISODIUM SALT, [3',5',7-3H(N)]- METHOTREXATE DISODIUM SALT, [L-GLUTAMIC (1-14C)]

Disodium N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate

sodium methotrexate

L-Glutamic acid, N-4-(2,4-diamino-6-pteridinyl)methylmethylaminobenzoyl-, disodium salt

METHOTREXATUM

2-[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]aminopentanedioic acid

(+)-N-[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid disodium salt

(+)-N-[4-[[(2,4-Diaminopteridine-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid disodium salt

4-amino-n(sup10)-methylpteroylglutamicaciddisodiumsalt

amethopterinsodium

disodiummethotrexate

l-(+)-isodiumsal

mtxdisodium

METHOTREXATE DISODIUM

METHOTREXATE DISODIUM SALT

Methotrexate Disodium Salt Solution

L-GlutaMic acid,N-[4-[[(2,4-diaMino-6-pteridinyl)Methyl]MethylaMino]benzoyl]-, sodiuM salt(1:2)

Methotrexatedisodiumsal

Methotrexate disodium salt USP/EP/BP

Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate

N-[4-Cyano-3-(trifluoromethyl)|pheny/l-3-[(4-fluoropheny)thio)-2-hydroxy-2-methylpropionamide'

sodium (4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamate

D3-Methotrexate Disodium Salt

3-Hydroxyoctadecanoylcarnitine

7413-34-5

C20H20N8Na2O5

C20H20N8O52Na

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