ChemicalBook > CAS DataBase List > siomycin A
siomycin A
- Product Name
- siomycin A
- CAS No.
- 12656-09-6
- Chemical Name
- siomycin A
- Synonyms
- siomycin A;Salomycin A;Mutabilycin;Mutabillicin;Antibiotic 6741-21;AKFVOKPQHFBYCA-OFENGFFDSA-N;Mutabilycin, SporangioMycin, 6741-21, Mutabillicin;Alaninamide, N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-valyl-2,3-didehydroalanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexa...
- CBNumber
- CB91371285
- Molecular Formula
- C71H81N19O18S5
- Formula Weight
- 1648.84
- MOL File
- 12656-09-6.mol
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siomycin A Property
- Density
- 1.65±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: complete10 mg/ml, clear, colorless to faintly yellow
- form
- White solid.
- pka
- 10.43±0.46(Predicted)
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 15378
- Product name
- Siomycin A
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $396
- Updated
- 2024/03/01
TRC
- Product number
- S497053
- Product name
- Siomycin A
- Packaging
- 1000μg
- Price
- $545
- Updated
- 2021/12/16
Usbiological
- Product number
- S1013-86W
- Product name
- Siomycin A
- Packaging
- 500ug
- Price
- $582
- Updated
- 2021/12/16
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siomycin A Chemical Properties,Usage,Production
Uses
Siomycin A is an antibiotic that inhibits FoxM1.
Uses
Siomycin is a macrocyclic antibiotic with potent and selective antibacterial activity discovered in 1969. Siomycin is a potent inhibitor of the oncogenic transcription factor, FoxM1. The reduced transcription activity is reflected in the down regulation of protein and mRNA levels of FoxM1 and effects on down stream genes, Cdc25B, survivin and CENPB. In vitro, siomycin inhibits FoxM1-induced cell growth on soft agar and selectively kill transformed but not normal cells.
siomycin A Preparation Products And Raw materials
Raw materials
Preparation Products
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