3-deoxyvasicine
- Product Name
- 3-deoxyvasicine
- CAS No.
- 495-59-0
- Chemical Name
- 3-deoxyvasicine
- Synonyms
- 3-deoxyvasicine;Pyrrolo[2,1-b]quinazoline, 1,2,3,9-tetrahydro-
- CBNumber
- CB91374837
- Molecular Formula
- C11H12N2
- Formula Weight
- 172.23
- MOL File
- 495-59-0.mol
N-Bromosuccinimide Price
- Product number
- T304163
- Product name
- 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline
- Packaging
- 100mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- CHM0303628
- Product name
- 1,2,3,9-TETRAHYDROPYRROLO[2,1-B]QUINAZOLINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.39
- Updated
- 2021/12/16
3-deoxyvasicine Chemical Properties,Usage,Production
Uses
Desoxypeganine (Deoxypeganine), an alkaloid, is a potent and orally active cholinesterase (BChE and AChE) and selective MAO-A inhibitor, with IC50 values of 2, 17, and 2 μM, respectively. Desoxypeganine can be used for alcohol abuse research[1].
Definition
ChEBI: Deoxypeganine is a member of quinazolines.
in vivo
Desoxypeganine (10-30 mg/kg, gavage, once daily for 16 days) reduced ethanol intake and ethanol preference dose-dependently[1].
| Animal Model: | Female Alko alcohol (AA) rats (Thirty eight adult)[1] |
| Dosage: | 10, 20, 30 mg/kg |
| Administration: | Gavage, once daily in a volume of 10 ml/kg at 6:00 pm, for 16 days |
| Result: | Abolished ethanol preference. |
IC 50
BChE: 2 μM (IC50); AChE: 17 μM (IC50); MAO-A: 2 μM (IC50)
References
[1] Doetkotte R, et al. Reduction of voluntary ethanol consumption in alcohol-preferring Alko alcohol (AA) rats by desoxypeganine and galanthamine. Eur J Pharmacol. 2005 Oct 17;522(1-3):72-7. DOI:10.1016/j.ejphar.2005.08.038
[2] Zheng XY, et al. Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay. Arch Pharm Res. 2009 Sep;32(9):1245-51. DOI:10.1007/s12272-009-1910-x
3-deoxyvasicine Preparation Products And Raw materials
Raw materials
Preparation Products
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