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L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE

Product Name
L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE
CAS No.
31828-68-9
Chemical Name
L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE
Synonyms
L-HCT-HCL;H-HOCYS-THIOLACTONE HCL;L-HOMOCYSTEINETHIOLACTONEHCL;-3-Aminodihydrothiophen-2(3H);L-HOMOCYSTEINE THIOLACTONE HCL*CRYST;L-HOMOCYSTEINETHILOACTONEHYDROCHLORIDE;(3S)-3-aminothiolan-2-one hydrochloride;L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE;L-HOMOCYSTEINE THIOLACTONE HCL*CRYSTALLI NE;L-Homocysteine thiolactone hydrochloride
CBNumber
CB9137747
Molecular Formula
C4H8ClNOS
Formula Weight
153.63
MOL File
31828-68-9.mol
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L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE Property

Melting point:
185-191 °C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Aqueous Acid (Slightly), DMSO (Slightly), Water (Slightly)
form 
Solid
color 
Pale Beige
BRN 
3911455
Stability:
Hygroscopic
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
F 
1-8-9
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H6503
Product name
L-Homocysteine thiolactone hydrochloride
Purity
≥98% (TLC)
Packaging
1g
Price
$647
Updated
2025/07/31
Sigma-Aldrich
Product number
H6503
Product name
L-Homocysteine thiolactone hydrochloride
Purity
≥98% (TLC)
Packaging
100mg
Price
$108.29
Updated
2025/07/31
Sigma-Aldrich
Product number
H6503
Product name
L-Homocysteine thiolactone hydrochloride
Purity
≥98% (TLC)
Packaging
250mg
Price
$199
Updated
2025/07/31
Sigma-Aldrich
Product number
H6503
Product name
L-Homocysteine thiolactone hydrochloride
Purity
≥98% (TLC)
Packaging
5g
Price
$2330
Updated
2025/07/31
TRC
Product number
H591960
Product name
L-Homocysteine thiolactone hydrochloride
Packaging
5g
Price
$1200
Updated
2021/12/16
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L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Colourless solid

Uses

L-Homocysteine Thiolactone Hydrochloride is used to prepare substituted homocysteine analogs as inhibitors of peptidylglycine α-amidating monooxygenase. It is also used to synthesize (mercaptoacyl)alanylprolines as metalloprotease inhibitors.

Biochem/physiol Actions

L-Homocysteine thiolactone, an amine reactive agent, is used to study post-translational modification of proteins, especially at lysine residues.

in vivo

L-Homocysteine thiolactone hydrochloride can be used to create models of hyperhomocysteinemia[2].

Induction of Hyperhomocysteinemia (HHcy)[2][3]
Background
Homocysteine (Hcy) is an amino acid that requires vitamins B12 and folic acid for its metabolism. Vitamins B12 and folic acid deficiencies lead to hyperhomocysteinemia (HHcy, elevated Hcy), which is linked to the development of diabetic retinopathy (DR), age-related macular degeneration (AMD), and Alzheimer’s disease (AD).
Specific Modeling Methods
Male C57Mice: cbs+/-; 3-5 weeks ? C57BL6/J; 6-8 weeks of age
Administration: 1 μL ? intravitreally ? 200 μM BL/6 mice (5 weeks old)
Note
(1) To avoid uncontrolled intraocular pressure increase, the volume of intravitreal injections is limited to 1 μL.
(2) L-Homocysteine thiolactone hydrochloride is dissolved in water and a working solution of 10x is prepared by diluting 1 μL of stock solution (200 mM) to 100 μL with PBS. Then by injecting 1 μL of this working solution, 200 μM vitreal concentration of Hcy-thiolactone is obtained.
Modeling Indicators
Molecular changes: Caused microglia activation in the retina. Increased indicators: pro-inflammatory cytokines IP-10, TNFα, IL-1β, and IL6
Correlated Product(s): L-Homocysteine (HY-W010347)
Opposite Product(s): /

Animal Model:cbs+/- mice and normal wild type mice (C57BL6/J), 6-8 weeks of age[2]
Dosage:1 μL; 200 μM
Administration:Intravitreally
Result:Normal retinal flat-mount preparations from cbs+/+ mice showed quiescent ramified microglia, while cbs-/- and cbs+/- retinas demonstrated rod-like microglia devoid of branching processes, indicating microglia activation in HHcy mice.

L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE Suppliers

China 65 Germany 1 India 1 Switzerland 1 United Kingdom 1 United States 16 Global 85
China DongFan Chemical Co.,LTD
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86-0571-85151182
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86-0571-85151182
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China
ProdList
5691
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66
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
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57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
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57
Tianjin heowns Biochemical Technology Co., Ltd.
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400 638 7771
Email
sales@heowns.com
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China
ProdList
14435
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57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
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China
ProdList
9815
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Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
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marketing_china@spectrumchemical.com
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China
ProdList
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UHN Shanghai Research & Development Co., Ltd.
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021-58958002 18930822973
Fax
+86 (21) 5895-8628
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sales@uhnshanghai.com
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China
ProdList
998
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Guangzhou Isun Pharmaceutical Co., Ltd
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020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
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China
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4720
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HBCChem, Inc.
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+1-510-219-6317
Fax
+1-650-486-1361
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sales@hbcchem.com
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United States
ProdList
10648
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60
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
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View Lastest Price from L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
L-HoMocysteine Thiloactone Hydrochloride 31828-68-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100kg
Release date
2025-09-24
Career Henan Chemical Co
Product
L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE 31828-68-9
Price
US $6.00/KG
Min. Order
2KG
Purity
98%
Supply Ability
1KG,50KG,100KG
Release date
2019-09-03

31828-68-9, L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDERelated Search:

L-Cysteine 4-MERCAPTOBUTYRIC ACID Homocystine L-Homocystine L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE - REFERENCE SPECTRUM D-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE 3-THIOPHENAMINE, TETRAHYDRO- 4-BUTYROTHIOLACTONE DL-Homocysteinethiolactone hydrochloride 3-Aminodihydrothiophen-2-one HOMOCYSTEINE THIOLACTONE L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE

  • L-Homocysteine thiolactone hydrochloride,L-2-Amino-4-mercaptobutyric acid 1,4-thiolactone hydrochloride
  • CAindexname:2(3H)-Thiophenone,3-aminodihydro-,hydr
  • (S)-3-Aminodihydro-2(3H)-thiophenone hydrochloride
  • L-HOMOCYSTEINE THIOLACTONE HCL*CRYST
  • -3-Aminodihydrothiophen-2(3H)
  • H-HOCYS-THIOLACTONE HCL
  • 2(3H)-THIOPHENONE, 3-AMINODIHYDRO-, HYDROCHLORIDE, (3S)-
  • 2(3H)-THIOPHENONE, 3-AMINODIHYDRO-, HYDROCHLORIDE, L-
  • 2(3H)-THIOPHENONE, 3-AMINODIHYDRO-, HYDROCHLORIDE, (S)-
  • (S)-3-aminodihydrothiophen-2(3H)-one hydrochloride
  • L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE ULTRA-PURE
  • L-HOMOCYSTEINE THIOLACTONE HCL*CRYSTALLI NE
  • L-HOMOCYSTEINETHILOACTONEHYDROCHLORIDE
  • L-HOMOCYSTEINETHIOLACTONEHCL
  • L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE
  • L-2-AMINO-4-MERCAPTOBUTYRIC ACID 1,4-THIOLACTONE HYDROCHLORIDE
  • (3S)-3-aminothiolan-2-one hydrochloride
  • LHomocysteine thiolactone hydrochloride,L Homocysteine thiolactone hydrochloride
  • L-HCT-HCL
  • <sc>L</sc>-Homocysteine thiolactone hydrochloride
  • 31828-68-9
  • 31828-69-9
  • C4H8ClNOS
  • Homo-Amino Acids
  • Peptide Synthesis
  • Specialty Synthesis
  • Unnatural Amino Acid Derivatives