DL-Homocysteinethiolactone hydrochloride
- Product Name
- DL-Homocysteinethiolactone hydrochloride
- CAS No.
- 6038-19-3
- Chemical Name
- DL-Homocysteinethiolactone hydrochloride
- Synonyms
- DL-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE;DL-HOMOCYSTEINE THIOLACTONE HCL;DL-HCT;hctlhydrochloride;TIMTEC-BB SBB004035;DL-Homocysteinethiol;3-aminothiolan-2-one;Erdosteine Impurity 7 (HCl);1,4-thiolactone hydrochloride;DL-HOMOCYSTEIN THIOLACTONE HCL
- CBNumber
- CB4429407
- Molecular Formula
- C4H8ClNOS
- Formula Weight
- 153.63
- MOL File
- 6038-19-3.mol
DL-Homocysteinethiolactone hydrochloride Property
- Melting point:
- 202 °C (dec.)(lit.)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Fine Crystalline Powder
- color
- White
- Water Solubility
- 740.5 g/L (20 C)
- Merck
- 14,4734
- BRN
- 3562103
- InChI
- InChI=1S/C4H7NOS.ClH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H
- InChIKey
- ZSEGSUBKDDEALH-UHFFFAOYSA-N
- SMILES
- C1(N)CCSC1=O.Cl
- CAS DataBase Reference
- 6038-19-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 53530
- Product name
- DL-Homocysteine thiolactone hydrochloride
- Purity
- ≥99.0% (AT)
- Packaging
- 25g
- Price
- $47.3
- Updated
- 2024/03/01
- Product number
- H0646
- Product name
- DL-Homocysteinethiolactone Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $26
- Updated
- 2025/07/31
- Product number
- H7001
- Product name
- DL-Homocysteine Thiolactone Hydrochloride
- Packaging
- 25g
- Price
- $312
- Updated
- 2021/12/16
- Product number
- 278950
- Product name
- dlHomocysteine thiolactone hydrochloride
- Packaging
- 25g
- Price
- $325
- Updated
- 2021/12/16
- Product number
- 8H70-5-Z1
- Product name
- DL-Homocysteine thiolactone hydrochloride
- Packaging
- 100g
- Price
- $77
- Updated
- 2021/12/16
DL-Homocysteinethiolactone hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White Crystalline Powder
Uses
DL-Homocysteine thiolactone hydrochloride is used as an intermediate of erdosteine and citiolone.
General Description
DL-Homocysteine thiolactone hydrochloride (HTL-HCl) is a cyclic amino acid derivative that exhibits root-growth inhibitory activity.
Synthesis
454-29-5
6038-19-3
The general procedure for the synthesis of DL-homocysteine thiolactone hydrochloride from DL-homocysteine was as follows: 100 g of DL-methionine was added to a 3-liter cryogenic autoclave pre-cooled to -40°C in a dry ice-acetonitrile solvent mixture, followed by the slow addition of dry ammonia until DL-methionine in the concentrated liquid ammonia was completely dissolved. At a reaction temperature of -35 to -40°C, 60 g of chopped sodium metal was added in batches and the reaction process was followed by liquid chromatography. Upon completion of the reaction, stirring was stopped, the reaction mixture was allowed to stand, and the upper clear night layer was carefully transferred to another three-necked flask. Ammonium chloride was added to quench the reaction and the reaction mixture was allowed to warm up naturally to room temperature until ammonia was completely spilled. The resulting solid was a mixture of DL-homocysteine sodium salt, sodium chloride and ammonium chloride. Treatment by a cation exchange resin to remove sodium ions and subsequent adjustment of the eluate to pH 1 with concentrated hydrochloric acid resulted in 81 g of DL-homocysteine thiolactone hydrochloride in 79% yield.
References
[1] Patent: CN107325073, 2017, A. Location in patent: Paragraph 0018; 0019; 0020; 0021; 0022; 0023; 0024-0034
DL-Homocysteinethiolactone hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DL-Homocysteinethiolactone hydrochloride manufacturers
- Product
- DL-Homocysteinethiolactone hydrochloride 6038-19-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98.5%min HPLC
- Supply Ability
- 5000kg
- Release date
- 2025-09-25
- Product
- DL-Homocysteinethiolactone hydrochloride 6038-19-3
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 100 tons
- Release date
- 2024-08-14
- Product
- Erdosteine Impurity 2(Hydrochloride) 6038-19-3
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 95%+
- Supply Ability
- 10000
- Release date
- 2025-01-22