pyropheophorbide a

Product Name: pyropheophorbide a
CAS No.: 24533-72-0
Chemical Name: pyropheophorbide a
Synonyms: Pyrophaeophorbid A;Pyropheophorbide-α;Ppyropheophorbide a;Pyropheophorbide-alpha;Chlorophyll Impurity 6;Magnesium pyrophyllate a;31,32-Didehydrophytochlorin;3-Deethyl-3-vinylphytochlorin;Pyropheophorbide-a, 10 mM in DMSO;(17S,18S)-3-Vinyl-3-deethyl-17,18-dihydrophytoporphyrin
CBNumber: CB91382063
Molecular Formula: C33H34N4O3
Formula Weight: 534.65
MOL File: 24533-72-0.mol

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pyropheophorbide a Property

storage temp.: 4°C, protect from light
solubility: DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
form: A crystalline solid
Boiling point:: 1006.4±65.0 °C(Predicted)
Density: 1.259±0.06 g/cm3(Predicted)
color: Brown to black
InChIKey: HXQUZGMYNSSKBE-RZSZZPGGSA-N
SMILES: C12CC(=O)C3C=1NC(C=3C)C=C1NC(C(C)=C1CC)=CC1NC(=C(C)C=1C=C)C=C1N=C2[C@@H](CCC(O)=O)[C@@H]1C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21371
Product name: Pyropheophorbide a
Purity: ≥98%
Packaging: 5mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 21371
Product name: Pyropheophorbide a
Purity: ≥98%
Packaging: 10mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 21371
Product name: Pyropheophorbide a
Purity: ≥98%
Packaging: 25mg
Price: $268
Updated: 2024/03/01

Cayman Chemical

Product number: 21371
Product name: Pyropheophorbide a
Purity: ≥98%
Packaging: 50mg
Price: $469
Updated: 2024/03/01

AccelPharmtech

Product number: WW1213
Product name: Pyropheophorbide-a
Purity: 95.00%
Packaging: 1G
Price: $1040
Updated: 2021/12/16

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pyropheophorbide a Chemical Properties,Usage,Production

Uses

Pyropheophorbide-a (Ppa) is a photosensitizer used in photodynamic therapy (PDT) for tumors. Pyropheophorbide-a exhibits phototoxic effects on tumor cells, such as cervical cancer cells, and also has anti-lipogenesis activity. Pyropheophorbide-a shows potential for research in the fields of cancer and age-related macular degeneration (AMD). Pyropheophorbide-a derivatives also demonstrate inhibitory activity against tumor cells[1][2][3][4].

Definition

ChEBI: Pyropheophorbide a is a pheophorbide. It is a conjugate acid of a pyropheophorbide a anion.

in vivo

Pyropheophorbide-a (1.25 or 2.5 mg/kg, i.v., administration period of 6 hours) exhibits anti-tumor activity in the C57BL/6 mouse model with TC-1 tumor implanted in the peritoneum^[4].

Animal Model:	C57BL/6 mice model
Dosage:	1.25 or 2.5 mg/kg
Administration:	intravenous injections (i.v.), 6 h
Result:	Resulted in rapid shrinkage of tumors after irradiation. While tumors treated with the same amount of Ppa-only (no irradiation) showed a slow growth

References

[1] Li W, et al. cRGD Peptide-Conjugated Pyropheophorbide-a Photosensitizers for Tumor Targeting in Photodynamic Therapy. Mol Pharm. 2018 Apr 2;15(4):1505-1514. DOI:10.1021/acs.molpharmaceut.7b01064
[2] Liu YH, et al. Anti-adipogenic activities of pheophorbide a and pyropheophorbide a isolated from wild bitter gourd (Momordica charantia L. var. abbreviata Seringe) in vitro. J Sci Food Agric. 2022 Nov;102(14):6771-6779. DOI:10.1002/jsfa.12044
[3] Bao L L, et al. In vitro and in vivo evaluation of a pyropheophorbide-a derivative as a potential photosensitizer for age-related macular degeneration[J]. Biomedicine & Pharmacotherapy, 2017, 88: 1220-1226.
[4] Chaturvedi P K, et al. Phototoxic effects of pyropheophorbide-a from chlorophyll-a on cervical cancer cells[J]. Journal of Porphyrins and Phthalocyanines, 2014, 18(03): 182-187.

pyropheophorbide a Preparation Products And Raw materials

Raw materials

Preparation Products

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pyropheophorbide a Suppliers

China 102 South Korea 1 United States 8 Global 111

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View Lastest Price from pyropheophorbide a manufacturers

Career Henan Chemical Co

Product: pyropheophorbide a 24533-72-0
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-15

24533-72-0, pyropheophorbide aRelated Search:

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24533-72-0

Porphyrins