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viridicatumtoxin

Product Name
viridicatumtoxin
CAS No.
39277-41-3
Chemical Name
viridicatumtoxin
Synonyms
NSC 159628;viridicatumtoxin;Spiro[2-cyclohexene-1,2'(1'H)-cyclopenta[de]naphthacene]-9'-carboxamide, 7',7'a,8',11',11'a,12'-hexahydro-5',6',7'a,10',11'a,12'-hexahydroxy-3'-methoxy-2,6,6-trimethyl-7',8'-dioxo-, (1R,7'aR,11'aR,12'R)-rel-(-)-
CBNumber
CB91382922
Molecular Formula
C30H31NO10
Formula Weight
565.57
MOL File
39277-41-3.mol
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viridicatumtoxin Property

Melting point:
235°C (rough estimate)
Boiling point:
630.75°C (rough estimate)
Density 
1.3203 (rough estimate)
refractive index 
1.6310 (estimate)
storage temp. 
Store at -20°C
solubility 
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
form 
A solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25480
Product name
Viridicatumtoxin
Purity
≥98%
Packaging
1mg
Price
$227
Updated
2024/03/01
Cayman Chemical
Product number
25480
Product name
Viridicatumtoxin
Purity
≥98%
Packaging
5mg
Price
$954
Updated
2024/03/01
TRC
Product number
V673905
Product name
Viridicatumtoxin
Packaging
1mg
Price
$230
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BIO0000728
Product name
VIRIDICATUMTOXIN
Purity
95.00%
Packaging
5MG
Price
$504.9
Updated
2021/12/16
AK Scientific
Product number
2060DM
Product name
Viridicatumtoxin
Packaging
5mg
Price
$1161
Updated
2021/12/16
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viridicatumtoxin Chemical Properties,Usage,Production

Description

Viridicatumtoxin in a mycotoxin originally isolated from Penicillium that has diverse biological activities, including antimicrobial, cytotoxic, and toxic properties. It inhibits the growth of B. subtilis, M. luteus, C. perfringens, B. fragilis, and methicillin-resistant S. aureus (MRSA; MICs = 0.39-1.56 μg/ml), as well as C. albicans, S. cerevisiae, M. racemosus, A. niger, and P. chrysogenum (MICs = 6.2-25 μg/ml), but has no activity against M. smegmatis, E. coli, K. pneumoniae, P. aeruginosa, or S. marcescens (MICs = >100 μg/ml). Viridicatumtoxin inhibits the production of polyprenyl alcohols by S. aureus undecaprenyl pyrophosphate (UPP) synthase, E. coli octaprenyl pyrophosphate synthase (OPS), and S. cerevisiae dehydrodolichyl pyrophosphate (DedoIPP) synthase in vitro (IC50s = 3.1, 21, and 71 μM, respectively). It has cytotoxic effects against human Jurkat T (IC50 = 4.92 μM), chronic lymphocytic leukemia (CLL; LC50 = 0.7-3.5 nM), and bone marrow-derived HS-5 stromal cells. Viridicatumtoxin is toxic to rats and mice when administered intraperitoneally (LD50s = 80 and 90 mg/kg, respectively) and to rats when administered via gastric intubation (LD50 = 122.4 mg/kg), but not to rats or mice when administered orally or through subcutaneous injection.

Uses

Viridicatumtoxin is a tetracycline-like metabolite produced by several species of Penicillium, first isolated in 1976 as a mycotoxin. Initial testing revealed that viridicatumtoxin caused myocardial deterioration, renal tubule necrosis and spleen atrophy. Analogous to the related tetracyclines, viridicatumtoxin was found to be a potent antibacterial, with activity against S. aureus including MRSA and QRSA strains. Little has been published on the mode of action of viridicatumtoxin.

Uses

Viridicatumtoxin is a tetracycline-like metabolite produced by several species of Penicillium.

Definition

ChEBI: A tetracycline-like polyketide antibiotic that is produced by several species of Penicillium and Aspergillus.

viridicatumtoxin Preparation Products And Raw materials

Raw materials

Preparation Products

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39277-41-3, viridicatumtoxinRelated Search:


  • viridicatumtoxin
  • NSC 159628
  • Spiro[2-cyclohexene-1,2'(1'H)-cyclopenta[de]naphthacene]-9'-carboxamide, 7',7'a,8',11',11'a,12'-hexahydro-5',6',7'a,10',11'a,12'-hexahydroxy-3'-methoxy-2,6,6-trimethyl-7',8'-dioxo-, (1R,7'aR,11'aR,12'R)-rel-(-)-
  • 39277-41-3
  • C30H31NO10