6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE
- Product Name
- 6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE
- CAS No.
- 22246-13-5
- Chemical Name
- 6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE
- Synonyms
- AKOS BB-9801;6-amino-3,4-dihydrocarbostyril;6-Amino-3,4-dihydroquinolin-2(1H);6-AMino-1,3,4-trihydro-quinolin-2-one;6-amino-3,4-dihydro-2(1 )-quinalinone;6-AMINO-3,4-DIHYDRO-2(1H)-QUINOLINONE;6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE;6-Amino-3,4-dihydroquinoline-2(1H)-one;6-aMino-3,4-dihydro-2(1H )-quinalinone;2(1H)-Quinolinone, 6-amino-3,4-dihydro-
- CBNumber
- CB9138360
- Molecular Formula
- C9H10N2O
- Formula Weight
- 162.19
- MOL File
- 22246-13-5.mol
6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE Property
- Melting point:
- 174-176 °C
- Boiling point:
- 423.0±45.0 °C(Predicted)
- Density
- 1.237±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 14.47±0.20(Predicted)
- Appearance
- Light yellow to light brown Solid
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A604480
- Product name
- 6-Amino-3,4-dihydrocarbostyril
- Packaging
- 250mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- P000358825
- Product name
- 6-Amino-3,4-dihydroquinolin-2(1H)-one
- Purity
- 97+%
- Packaging
- 100mg
- Price
- $41
- Updated
- 2021/12/16
- Product number
- P000358825
- Product name
- 6-Amino-3,4-dihydroquinolin-2(1H)-one
- Purity
- 97+%
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- FA133592
- Product name
- 6-Amino-3,4-dihydroquinolin-2(1H)-one
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- Z4435
- Product name
- 6-Amino-3,4-dihydroquinolin-2(1H)-one
- Packaging
- 250mg
- Price
- $144
- Updated
- 2021/12/16
6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE Chemical Properties,Usage,Production
Uses
6-Amino-3,4-dihydrocarbostyril is a useful synthetic compound used to prepare cardiotonic agents.
Synthesis
22246-16-8
22246-13-5
At 0 °C, 6-nitro-3,4-dihydroquinolin-2(1H)-one (3 g) was dissolved in methanol (60 mL) and zinc powder (5 eq.) and ammonium chloride (5 eq.) were added sequentially. The reaction mixture was stirred at room temperature for 1 h. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was filtered through a bed of diatomaceous earth and the filtrate was concentrated under reduced pressure. The residue was dissolved in a dichloromethane solution containing 5% methanol and subsequently washed with water. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford 6-amino-3,4-dihydroquinolin-2(1H)-one (2.3 g in 91% yield. The product was characterized by 1H NMR (DMSO-d6, 400MHz): δ 9.654 (broad single peak, 1H), 6.53 (double peak, 1H), 6.378-6.334 (multiple peaks, 2H), 4.707 (broad single peak, 2H), 2.699 (triple peak, 2H), 2.330 (triple peak, 2H).
References
[1] Patent: WO2015/38417, 2015, A1. Location in patent: Page/Page column 90; 91
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 16, p. 4606 - 4609
[3] Patent: WO2006/71940, 2006, A2. Location in patent: Page/Page column 416
[4] Proceedings of the Imperial Academy (Tokyo), 1939, vol. 15, p. 148,153
[5] Chem. Zentralbl., 1939, vol. 110, # II, p. 3089
6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE manufacturers
- Product
- 6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE 22246-13-5
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-09