ChemicalBook > CAS DataBase List > 6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE

6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE

Product Name
6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE
CAS No.
22246-13-5
Chemical Name
6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE
Synonyms
AKOS BB-9801;6-amino-3,4-dihydrocarbostyril;6-Amino-3,4-dihydroquinolin-2(1H);6-AMino-1,3,4-trihydro-quinolin-2-one;6-amino-3,4-dihydro-2(1 )-quinalinone;6-AMINO-3,4-DIHYDRO-2(1H)-QUINOLINONE;6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE;6-Amino-3,4-dihydroquinoline-2(1H)-one;6-aMino-3,4-dihydro-2(1H )-quinalinone;2(1H)-Quinolinone, 6-amino-3,4-dihydro-
CBNumber
CB9138360
Molecular Formula
C9H10N2O
Formula Weight
162.19
MOL File
22246-13-5.mol
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6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE Property

Melting point:
174-176 °C
Boiling point:
423.0±45.0 °C(Predicted)
Density 
1.237±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
14.47±0.20(Predicted)
Appearance
Light yellow to light brown Solid
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Safety

HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A604480
Product name
6-Amino-3,4-dihydrocarbostyril
Packaging
250mg
Price
$65
Updated
2021/12/16
Ark Pharm
Product number
P000358825
Product name
6-Amino-3,4-dihydroquinolin-2(1H)-one
Purity
97+%
Packaging
100mg
Price
$41
Updated
2021/12/16
Ark Pharm
Product number
P000358825
Product name
6-Amino-3,4-dihydroquinolin-2(1H)-one
Purity
97+%
Packaging
250mg
Price
$70
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA133592
Product name
6-Amino-3,4-dihydroquinolin-2(1H)-one
Packaging
250mg
Price
$125
Updated
2021/12/16
AK Scientific
Product number
Z4435
Product name
6-Amino-3,4-dihydroquinolin-2(1H)-one
Packaging
250mg
Price
$144
Updated
2021/12/16
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6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE Chemical Properties,Usage,Production

Uses

6-Amino-3,4-dihydrocarbostyril is a useful synthetic compound used to prepare cardiotonic agents.

Synthesis

22246-16-8

22246-13-5

At 0 °C, 6-nitro-3,4-dihydroquinolin-2(1H)-one (3 g) was dissolved in methanol (60 mL) and zinc powder (5 eq.) and ammonium chloride (5 eq.) were added sequentially. The reaction mixture was stirred at room temperature for 1 h. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was filtered through a bed of diatomaceous earth and the filtrate was concentrated under reduced pressure. The residue was dissolved in a dichloromethane solution containing 5% methanol and subsequently washed with water. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford 6-amino-3,4-dihydroquinolin-2(1H)-one (2.3 g in 91% yield. The product was characterized by 1H NMR (DMSO-d6, 400MHz): δ 9.654 (broad single peak, 1H), 6.53 (double peak, 1H), 6.378-6.334 (multiple peaks, 2H), 4.707 (broad single peak, 2H), 2.699 (triple peak, 2H), 2.330 (triple peak, 2H).

References

[1] Patent: WO2015/38417, 2015, A1. Location in patent: Page/Page column 90; 91
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 16, p. 4606 - 4609
[3] Patent: WO2006/71940, 2006, A2. Location in patent: Page/Page column 416
[4] Proceedings of the Imperial Academy (Tokyo), 1939, vol. 15, p. 148,153
[5] Chem. Zentralbl., 1939, vol. 110, # II, p. 3089

6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE Suppliers

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View Lastest Price from 6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE manufacturers

Career Henan Chemical Co
Product
6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE 22246-13-5
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-09

22246-13-5, 6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONERelated Search:

Aminoguanidine bicarbonate 6,8-DINITRO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE VESNARINONE 3,4-Dihydro-6-nitro-2(1H)-quinolinone 6-(1-PIPERAZINYL)-3,4-DIHYDROCARBOSTYRIL MONOHYDROBROMIDE 6-PIPERAZIN-1-YL-3,4-DIHYDRO-1H-QUINOLIN-2-ONE AURORA KA-4837 6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE AURORA KA-2344 AURORA KA-5364 AURORA KA-5365 AURORA KA-4790

  • 6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE
  • 6-AMINO-3,4-DIHYDRO-2(1H)-QUINOLINONE
  • AKOS BB-9801
  • 6-amino-3,4-dihydro-2(1 )-quinalinone
  • 6-AMino-1,3,4-trihydro-quinolin-2-one
  • 6-aMino-3,4-dihydro-2(1H )-quinalinone
  • 6-amino-3,4-dihydrocarbostyril
  • 6-Amino-3,4-dihydroquinoline-2(1H)-one
  • 6-Amino-3,4-dihydroquinolin-2(1H)
  • 2(1H)-Quinolinone, 6-amino-3,4-dihydro-
  • 22246-13-5
  • pharmacetical