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pyripyropene A

Product Name
pyripyropene A
CAS No.
147444-03-9
Chemical Name
pyripyropene A
Synonyms
FO 1289A;pyripyropene A;Pyripyropene A, ACAT2 inhibitor;2H,11H-Naphtho[2,1-b]pyrano[3,4-e]pyran-11-one, 3,6-bis(acetyloxy)-4-[(acetyloxy)methyl]-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-12-hydroxy-4,6a,12b-trimethyl-9-(3-pyridinyl)-, (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-
CBNumber
CB91387745
Molecular Formula
C31H37NO10
Formula Weight
583.63
MOL File
147444-03-9.mol
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pyripyropene A Property

Melting point:
153-154℃
Boiling point:
690.8±55.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C, protect from light, stored under nitrogen
solubility 
DMSO: Soluble; Methanol: Soluble
pka
11.72±0.70(Predicted)
form 
White to brown powder.
color 
Pale pink to rusty brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11896
Product name
Pyripyropene A
Purity
≥95%
Packaging
250μg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
11896
Product name
Pyripyropene A
Purity
≥95%
Packaging
1mg
Price
$456
Updated
2024/03/01
Usbiological
Product number
045185
Product name
Pyripyropene A
Packaging
250ug
Price
$358
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0004030
Product name
PYRIPYROPENE A
Purity
95.00%
Packaging
5MG
Price
$497.27
Updated
2021/12/16
AK Scientific
Product number
1162CT
Product name
PyripyropeneA
Packaging
1mg
Price
$606
Updated
2021/12/16
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pyripyropene A Chemical Properties,Usage,Production

Uses

Pyripyropene A exhibits insecticidal properties and a useful compound for developing agrichemicals.

Definition

ChEBI: A sesquiterpenoid that consists of (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-4-(acetoxymethyl)-12-hydroxy-4,6a,12b-trimethyl-11-o o-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diol in which the hydrogens of the 3- and 6-hydroxy functions are substituted by acetyl groups.

in vivo

Pyripyropene A (10-50 mg/kg per day; p.o; 12 weeks) reduces the levels of plasma cholesterol, very-low-density lipoprotein (VLDL), and low-density lipoprotein (LDL) and hepatic cholesterol content in apolipoprotein E-knockout mice. And Pyripyropene A-treated mice display reduction of atherogenic lesion areas in the aortae and heart[3].
? Pyripyropene A inhibits the hepatic e acyl–coenzyme A:cholesterol acyltransferase 2? (ACAT2) activity in vivo[3].
? Pyripyropene A displays a half-life (t1/2) of 0.693/λ, where λ represented the terminal slope of the log-linear portion of concentration time profile[4].

Animal Model:Male C57BL/6 mice[2]
Dosage:0 mg/kg, 1 mg/kg, 10 mg/kg, 50 mg/kg, 100 mg/kg
Administration:Oral administration; daily; for 12 weeks
Result:Reduced atherogenic lesion areas in the aortae and heart.
Animal Model:9-week old male ICR mice (pharmacokinetic analysis)[4]
Dosage:5 mg/kg ,10 mg/kg
Administration:Oral administration
Result:t1/2 = 0.693/λ

storage

+4°C

pyripyropene A Preparation Products And Raw materials

Raw materials

Preparation Products

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pyripyropene A Suppliers

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147444-03-9, pyripyropene ARelated Search:

3-ETHOXYCARBONYL-5,6-DIHYDRO-2-METHYL-4H-PYRAN VINYL LAURATE 2,6-Decahydronaphthalenediol VINYL DECANOATE ETHYL CYCLOHEXANEPROPIONATE VINYL NEODECANOATE CYCLOHEXYL VINYL ETHER Dodecyl vinyl ether ETHYL (R)-3-HYDROXY-TETRADECANOATE (S)-ETHYL 3-HYDROXY-4-METHYLPENTANOATE pyripyropene A BERRYFLOR 3-(3-PYRIDYL)-2-PROPEN-1-OL 3,4-dihydro-2,5-dimethyl-2H-pyran-2-methanol METHYL 3-HYDROXY-2-METHYLENEBUTYRATE pyripyropene B MYRISTIC ACID VINYL ESTER 2-METHYL-5,6-DIHYDRO-4H-PYRAN-3-CARBOXYLIC ACID

  • pyripyropene A
  • FO 1289A
  • 2H,11H-Naphtho[2,1-b]pyrano[3,4-e]pyran-11-one, 3,6-bis(acetyloxy)-4-[(acetyloxy)methyl]-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-12-hydroxy-4,6a,12b-trimethyl-9-(3-pyridinyl)-, (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-
  • Pyripyropene A, ACAT2 inhibitor
  • 147444-03-9
  • C31H37NO10