pyripyropene A
- Product Name
- pyripyropene A
- CAS No.
- 147444-03-9
- Chemical Name
- pyripyropene A
- Synonyms
- FO 1289A;pyripyropene A;Pyripyropene A, ACAT2 inhibitor;2H,11H-Naphtho[2,1-b]pyrano[3,4-e]pyran-11-one, 3,6-bis(acetyloxy)-4-[(acetyloxy)methyl]-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-12-hydroxy-4,6a,12b-trimethyl-9-(3-pyridinyl)-, (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-
- CBNumber
- CB91387745
- Molecular Formula
- C31H37NO10
- Formula Weight
- 583.63
- MOL File
- 147444-03-9.mol
pyripyropene A Property
- Melting point:
- 153-154℃
- Boiling point:
- 690.8±55.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C, protect from light, stored under nitrogen
- solubility
- DMSO: Soluble; Methanol: Soluble
- pka
- 11.72±0.70(Predicted)
- form
- White to brown powder.
- color
- Pale pink to rusty brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 11896
- Product name
- Pyripyropene A
- Purity
- ≥95%
- Packaging
- 250μg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 11896
- Product name
- Pyripyropene A
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $456
- Updated
- 2024/03/01
- Product number
- 045185
- Product name
- Pyripyropene A
- Packaging
- 250ug
- Price
- $358
- Updated
- 2021/12/16
- Product number
- INB0004030
- Product name
- PYRIPYROPENE A
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.27
- Updated
- 2021/12/16
- Product number
- 1162CT
- Product name
- PyripyropeneA
- Packaging
- 1mg
- Price
- $606
- Updated
- 2021/12/16
pyripyropene A Chemical Properties,Usage,Production
Uses
Pyripyropene A exhibits insecticidal properties and a useful compound for developing agrichemicals.
Definition
ChEBI: A sesquiterpenoid that consists of (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-4-(acetoxymethyl)-12-hydroxy-4,6a,12b-trimethyl-11-o o-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diol in which the hydrogens of the 3- and 6-hydroxy functions are substituted by acetyl groups.
in vivo
Pyripyropene A (10-50 mg/kg per day; p.o; 12 weeks) reduces the levels of plasma cholesterol, very-low-density lipoprotein (VLDL), and low-density lipoprotein (LDL) and hepatic cholesterol content in apolipoprotein E-knockout mice. And Pyripyropene A-treated mice display reduction of atherogenic lesion areas in the aortae and heart[3].
?
Pyripyropene A inhibits the hepatic e acyl–coenzyme A:cholesterol acyltransferase 2? (ACAT2) activity in vivo[3].
?
Pyripyropene A displays a half-life (t1/2) of 0.693/λ, where λ represented the terminal slope of the log-linear portion of concentration time profile[4].
| Animal Model: | Male C57BL/6 mice[2] |
| Dosage: | 0 mg/kg, 1 mg/kg, 10 mg/kg, 50 mg/kg, 100 mg/kg |
| Administration: | Oral administration; daily; for 12 weeks |
| Result: | Reduced atherogenic lesion areas in the aortae and heart. |
| Animal Model: | 9-week old male ICR mice (pharmacokinetic analysis)[4] |
| Dosage: | 5 mg/kg ,10 mg/kg |
| Administration: | Oral administration |
| Result: | t1/2 = 0.693/λ |
storage
+4°C
pyripyropene A Preparation Products And Raw materials
Raw materials
Preparation Products
pyripyropene A Suppliers
- Tel
- --
- Fax
- --
- alexis-ch@alexis-corp.com
- Country
- Switzerland
- ProdList
- 1104
- Advantage
- 80