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dryocrassin

Product Name
dryocrassin
CAS No.
12777-70-7
Chemical Name
dryocrassin
Synonyms
dryocrassin;Dryocrassin ABBA);Tetraalbaspidin ABBA;Methylenebisnorflavaspidic acid ABBA;2,5-Cyclohexadien-1-one, 2,2'-[methylenebis[[2,4,6-trihydroxy-5-(1-oxobutyl)-3,1-phenylene]methylene]]bis[6-acetyl-3,5-dihydroxy-4,4-dimethyl- (9CI);2-acetyl-4-[[3-[[3-[(5-acetyl-2,6-dihydroxy-3,3-dimethyl-4-oxocyclohexa-1,5-dien-1-yl)methyl]-5-butanoyl-2,4,6-trihydroxyphenyl]methyl]-5-butanoyl-2,4,6-trihydroxyphenyl]methyl]-3,5-dihydroxy-6,6-dimethylcyclohexa-2,4-dien-1-one
CBNumber
CB91394484
Molecular Formula
C43H48O16
Formula Weight
820.83
MOL File
12777-70-7.mol
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dryocrassin Property

Boiling point:
1089.0±65.0 °C(Predicted)
Density 
1.474±0.06 g/cm3 (20 ºC 760 Torr)
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
powder
pka
4.20±1.00(Predicted)
color 
Yellow
InChIKey
PRVKSKWNDSLRBY-UHFFFAOYSA-N
SMILES
C1(=O)C(C)(C)C(O)=C(CC2=C(O)C(C(=O)CCC)=C(O)C(CC3=C(O)C(C(=O)CCC)=C(O)C(CC4C(O)=C(C(C)=O)C(=O)C(C)(C)C=4O)=C3O)=C2O)C(O)=C1C(C)=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Usbiological
Product number
300204
Product name
Dryocrassin
Packaging
10mg
Price
$708
Updated
2021/12/16
Biorbyt Ltd
Product number
orb593897
Product name
Dryocrassin
Packaging
20mg
Price
$799
Updated
2021/12/16
ChemScene
Product number
CS-0009063
Product name
DryocrassinABBA
Purity
98.43%
Packaging
10mg
Price
$857
Updated
2021/12/16
Biorbyt Ltd
Product number
orb593897
Product name
Dryocrassin
Packaging
10mg
Price
$596.7
Updated
2021/12/16
ApexBio Technology
Product number
N2411
Product name
DryocrassinABBA
Packaging
20mg
Price
$450
Updated
2021/12/16
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dryocrassin Chemical Properties,Usage,Production

Chemical Properties

An active ingredient extracted from the dried rhizomes and petiole residues of Dryopteris crassipes, a plant of the Dryopteris family

Uses

Dryocrassin ABBA (Dryocrassin) is an orally active phloroglucinol derivative that can be extracted from Phyllopteris officinalis. Dryocrassin ABBA has antitumor and antiviral activity. Dryocrassin ABBA induced apoptosis of human hepatocellular carcinoma cells through mitochondrial pathway mediated by Caspase[1][2].

Biological Activity

Dryocrassin is a flavonoid natural product, a phloroglucinol derivative derived from Dryopteris crassirhizoma, with antiviral and antibacterial activities. Biological and pharmacological activities of dryocrassin have attracted attention. Dryocrassin exhibits antiviral activity against H5N1 avian influenza virus. Dryocrassin inhibits the coagulase activity of Staphylococcus aureus vWbp. Dryocrassin suppresses immunostimulatory function of dendritic cells and prolongs skin allograft survival.

in vivo

Dryocrassin ABBA (Dryocrassin) (0-33 mg/kg; i.g.; daily, 7 days from day 2 to day 8) exerts a significant dose-dependent antiviral effect in mice[1].
Dryocrassin ABBA (100 mg/kg; s.c.; every 12 h for 96 h) can reduce infection and prevent mice from contracting S. aureus pneumonia[3].

Animal Model:SPF BALB/C female mice inoculated intra-nasally with 104.5ELD50 H5N1 viruses in 100 μl saline[1]
Dosage:33, 18, and 12.5 mg/kg
Administration:Oral gavage, daily, 7 days from day 2 to day 8
Result:Significantly reduced mortality, prolonged survival rate, and improved survival time throughout the infection period. Increased body weight and reduced lung lesions and virus loads. Significantly increased MCP-1 and IL-10 while significantly decreased IL-12, IL-6, IFN-γ and TNF-α.
Animal Model:Eight-week-old C57BL/6J mice infected with 30 μL of S. aureus Newman (2 × 108 CFU/10 μL) by intranasal administration[3]
Dosage:100 mg/kg
Administration:Subcutaneous injection, every 12 h for 96 h
Result:Resulted a significant increase in survival.

target

Influenza virus | p53 | Bcl-2/Bax | Caspase | IL Receptor | TNF-α

References

[1] Ou C, et al. Dryocrassin ABBA, a novel active substance for use against amantadine-resistant H5N1 avian influenza virus. Front Microbiol. 2015 Jun 16;6:592. DOI:10.3389/fmicb.2015.00592
[2] Ou C, et al. Dryocrassin ABBA, a novel active substance for use against amantadine-resistant H5N1 avian influenza virus. Front Microbiol. 2015 Jun 16;6:592. DOI:10.3389/fmicb.2015.00592
[3] Jin Z, et al. Dryocrassin ABBA Induces Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells Through a Caspase-Dependent Mitochondrial Pathway. Asian Pac J Cancer Prev. 2016;17(4):1823-8. DOI:10.7314/apjcp.2016.17.4.1823
[4] Zhang B, et al. Molecular Mechanism of the Flavonoid Natural Product Dryocrassin ABBA against Staphylococcus aureus Sortase A. Molecules. 2016 Oct 26;21(11). DOI:10.3390/molecules21111428
[5] Li B, et al. An Inhibitory Effect of Dryocrassin ABBA on Staphylococcus aureus vWbp That Protects Mice From Pneumonia. Front Microbiol. 2019 Jan 23;10:7. DOI:10.3389/fmicb.2019.00007
[6] Fu RH, et al. Dryocrassin suppresses immunostimulatory function of dendritic cells and prolongs skin allograft survival. Cell Transplant. 2014;23(4-5):641-56. DOI:10.3727/096368914X678373

dryocrassin Preparation Products And Raw materials

Raw materials

Preparation Products

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dryocrassin Suppliers

China 132 United States 9 Global 141
Mensura Group Limited
Tel
17318633522
Fax
028-87362290
Email
18109034517@163.com
Country
China
ProdList
2898
Advantage
58
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
Shenzhen Sungening Bio-Tech Co., Ltd
Tel
+86-0755-89668383
Fax
+86-0755-89594066/4038
Email
sales@sungening.com
Country
China
ProdList
1319
Advantage
65
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
Chengdu Climax Biotech Co., Ltd.
Tel
028-83311324 1278112614
Fax
028-83311324
Email
climaxbiotech@gmail.com
Country
China
ProdList
925
Advantage
58
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai Ruji Biology Technology Co., Ltd.
Tel
+86-21-65211385-8001 36031160
Fax
+86-21-65211385-8004
Email
sales@shruji.com
Country
China
ProdList
3224
Advantage
55
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
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View Lastest Price from dryocrassin manufacturers

Career Henan Chemical Co
Product
dryocrassin 12777-70-7
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg , 5kg, 50kg
Release date
2020-01-17

12777-70-7, dryocrassinRelated Search:

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  • dryocrassin
  • 2-acetyl-4-[[3-[[3-[(5-acetyl-2,6-dihydroxy-3,3-dimethyl-4-oxocyclohexa-1,5-dien-1-yl)methyl]-5-butanoyl-2,4,6-trihydroxyphenyl]methyl]-5-butanoyl-2,4,6-trihydroxyphenyl]methyl]-3,5-dihydroxy-6,6-dimethylcyclohexa-2,4-dien-1-one
  • Dryocrassin ABBA)
  • Methylenebisnorflavaspidic acid ABBA
  • Tetraalbaspidin ABBA
  • 2,5-Cyclohexadien-1-one, 2,2'-[methylenebis[[2,4,6-trihydroxy-5-(1-oxobutyl)-3,1-phenylene]methylene]]bis[6-acetyl-3,5-dihydroxy-4,4-dimethyl- (9CI)
  • 12777-70-7
  • C45H48O16
  • C43H48O16
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract