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Iron-dextran

Product Name
Iron-dextran
CAS No.
9004-66-4
Chemical Name
Iron-dextran
Synonyms
IRON DEXTRAN;Iron dextran solution;INFeD;DexferruM;b75;a100;Dextran iron;fenate;Dexfer;Idofer
CBNumber
CB9139534
Molecular Formula
FeH2O4S
Formula Weight
153.92348
MOL File
9004-66-4.mol
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Iron-dextran Property

storage temp. 
Room Temperature
solubility 
Water (Slightly)
form 
solution
color 
Very Dark Red to Black
Water Solubility 
Iron, ~100?mg/mL in water
IARC
2B (Vol. 2, Sup 7) 1987
EPA Substance Registry System
Iron dextran (9004-66-4)
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Safety

Hazard Codes 
Xn,T
Risk Statements 
40-42/43-43-45
Safety Statements 
23-26-36/37/39-45-36-36/37-53
WGK Germany 
-
RTECS 
NI2200000
Hazardous Substances Data
9004-66-4(Hazardous Substances Data)
Toxicity
LD50 i.v. in mice: 2240 mg Fe/kg (Beliles)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H350May cause cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D8517
Product name
Iron–Dextran
Purity
solution
Packaging
25ml
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
D8517
Product name
Iron–Dextran
Purity
solution
Packaging
100ml
Price
$446
Updated
2024/03/01
TRC
Product number
I774950
Product name
IronDextran
Packaging
100g
Price
$1190
Updated
2021/12/16
Usbiological
Product number
280362
Product name
Iron dextran
Packaging
5g
Price
$337
Updated
2021/12/16
Usbiological
Product number
014961
Product name
Iron Dextran
Packaging
10g
Price
$425
Updated
2021/12/16
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Iron-dextran Chemical Properties,Usage,Production

Description

Iron dextran is a dark brown, slightly viscous liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Iron Dextran is used for the treatment of patients with documented iron deficiency in which oral administration is unsatisfactory or impossible. It is supplied as a parenteral preparation and is used as a hematinic. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1292)
Iron-Dextran is for the parenteral treatment of iron-deficiency anemia in humans and baby pigs. Can be used as a reagent.

Chemical Properties

Light to dark brown powder. Colloidal suspension of an iron-dextran complex in water. pH 5.2-6.5.

History

The therapeutic value of colloidal iron preparations was first reported in the 1950's by London and Twigg. Numerous attempts have been made to improve these iron preparations Thus dextran ([h] 0.05) is first heated with alkali, and is then neutralized in the presence of ferric chloride solution. Studies on this product have revealed that each particle consists of a central iron core, approximately 3nm diameter, surrounded by a dextran sheath of approximately 13nm diameter. The complex is visualized as a particle formed by a protective sheath of dextran attached by terminal metasaccharinic acid units to a b-FeOOH core. A solution of this complex containing 5% iron and 20% dextran (Imferon ™ ) is suitable for intramuscular and intravenous injection for treating iron deficiency anemia. The product is currently used widely for treating anemia in new-born piglets.
The use of these preparations has been re-examined in humans and a dramatic rise in hemoglobin was reported following intravenous infusion. The solution is best administered together with glucose solutions.

Uses

Hematinic.

Uses

Iron-Dextran (ferric hydroxide dextran complex) may be used as an intravenous iron delivery preparation. Iron-Dextran may be used to induce iron-overload to study its effects and preventative measures.

brand name

Dexferrum (Luitpold); Infed (Wat son); Proferdex (New River).

Reactivity Profile

Iron-dextran is unstable at a pH of 5 and decomposes at 149-158° F. Iron-dextran may be sensitive to prolonged exposure to air.

Health Hazard

SYMPTOMS: The symptoms associated with exposure to Iron-dextran are headaches, vomiting, and dizziness.

Fire Hazard

Iron-dextran is combustible.

Clinical Use

Prophylaxis of iron deficiency anaemia (when oral treatment is ineffective or contraindicated)

Treatment of iron deficiency during ESA therapy especially if serum ferritin is very low (<50 nanograms/mL)

Drug interactions

Potentially hazardous interactions with other drugs
Dimercaprol: avoid concomitant use.
Oral iron: reduced absorption of oral iron

Carcinogenicity

Iron dextran complex is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Metabolism

After intravenous infusion, iron dextran is taken up by the cells of the reticuloendothelial cells, particularly in the liver and spleen. The reticuloendothelial cells gradually separate iron from the iron-dextran complex. Most absorbed iron is bound to transferrin and transported to the bone marrow where it is incorporated into haemoglobin; the remainder is contained within the storage forms, ferritin or haemosiderin, or as myoglobin, with smaller amounts occurring in haem-containing enzymes or in plasma bound to transferrin.
Only very small amounts of iron are excreted as the majority released after the destruction of the haemoglobin molecule is re-used.

Iron-dextran Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Iron-dextran manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Iron-dextran 9004-66-4
Price
US $0.00/KG
Min. Order
25KG
Purity
20%(200mg Fe/ml);USP
Supply Ability
10 TONS
Release date
2021-06-18
Hebei Weibang Biotechnology Co., Ltd
Product
Iron-dextran 9004-66-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-01
Hebei Yanxi Chemical Co., Ltd.
Product
Iron-dextran 9004-66-4
Price
US $25.00-10.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-16

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