ChemicalBook > CAS DataBase List > 5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID

5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID

Product Name: 5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID
CAS No.: 27069-16-5
Chemical Name: 5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID
Synonyms: CHEMBRDG-BB 7270767;3-(4-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBO&;5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID;5-(4-Methoxyphenyl)-1H-pyrazole-3-carboxylic acid ,97%;5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid(SALTDATA: FREE);5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID ISO 9001：2015 REACH
CBNumber: CB9139817
Molecular Formula: C11H10N2O3
Formula Weight: 218.21
MOL File: 27069-16-5.mol

Less

5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID Property

Melting point:: 221-225 °C(lit.)
Boiling point:: 516.9±45.0 °C(Predicted)
Density: 1.340±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 3.93±0.10(Predicted)
form: solid
Appearance: White to off-white Solid

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29331990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CBR01174
Product name: 5-(4-Methoxyphenyl)-1H-pyrazole-3-carboxylic acid
Purity: Aldrich
Packaging: 1g
Price: $73.1
Updated: 2025/07/31

TRC

Product number: M329598
Product name: 5-(4-Methoxyphenyl)-1H-pyrazole-3-carboxylic acid
Packaging: 250mg
Price: $55
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0086920
Product name: 5-(4-METHOXY-PHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 500MG
Price: $773.85
Updated: 2021/12/16

Matrix Scientific

Product number: 138565
Product name: 5-(4-Methoxy-phenyl)-2H-pyrazole-3-carboxylic acid
Purity: 95%+
Packaging: 2.500g
Price: $215
Updated: 2021/12/16

Matrix Scientific

Product number: 138565
Product name: 5-(4-Methoxy-phenyl)-2H-pyrazole-3-carboxylic acid
Purity: 95%+
Packaging: 5g
Price: $323
Updated: 2021/12/16

Less

5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

55558-77-5

27069-16-5

4.1.1.1 Synthesis of 5-(4-methylphenyl)-1H-pyrazole-3-carboxylic acid (1): 0.4 g of 4-(4-methylphenyl)-2,4-dioxobutanoic acid was dissolved in 20 mL of glacial acetic acid in a 50 mL round bottom flask. Under stirring conditions, 280 μL (3 equivalents) of hydrazine monohydrate (N2H4-H2O) was added slowly and dropwise to the solution. Immediately after the dropwise addition of hydrazine, the solution changed to a light yellow color. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was poured into 50 mL of water and stirred overnight. The white precipitate was collected by filtration, dried in air and recrystallized from a solvent mixture of hexane/ethanol (about 9:1) to give 0.34 g of product in 87% yield. 4.1.2.22 Synthesis of 5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid (22): 0.50 g of 4-(4-methoxyphenyl)-2,4-dioxobutanoic acid was used as a starting material, and 0.45 g of the product was obtained in 92% yield by following the same procedure as above. The product is a white solid with a melting point of 226-228 °C (decomposition, hexane/ethyl acetate). The molecular formula was C11H10N2O3 and the molecular weight was 218.21. ESI-MS: [M+H]+ calculated value was 219.07642, measured value was 219.07540. IR (ν, cm-1): 3309, 3249 (N-H stretching vibration), 1679 (C=O stretching vibration), 1456, 1206. 1H NMR ( 200MHz, DMSO-d6) δ (ppm): 3.77 (s, 3H, OCH3), 6.99 (d, J=8.99Hz, 2H, Ar-H), 7.09 (s, 1H, pyrazole-H), 7.76 (d, J=8.42Hz, 2H, Ar-H), 13.21 (br, COOH).13C NMR ( 50MHz, DMSO-d6) δ (ppm): 55.45 (OCH3), 104.75, 114.60, 123.70, 127.00, 140.62, 147.45, 159.57, 162.43.

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 15, p. 4649 - 4659

5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

4'-Methoxyacetophenone Ethanol Hydrazine sulfate Potassium hydroxide Diethyl oxalate Sodium

Preparation Products

Less

5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID Suppliers

China 52 Germany 1 Hungary 1 India 2 Russia 2 Switzerland 1 Ukraine 1 United Kingdom 2 United States 16 Global 78

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Nanjing Habo Medical Technology Co., Ltd.

Tel: 025-85760892 13376080562
Fax: 025-85766769
Email: sales@habotech.com
Country: China
ProdList: 884
Advantage: 60

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Xi’an chemsoar Medical Technology Co., ltd

Tel: 029-86538357
Fax: 029-87871708
Country: China
ProdList: 234
Advantage: 57

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

EnliPharma Technology Co., Ltd

Tel: 0551-66399836 18955197623
Email: sales@enlipharma.com
Country: China
ProdList: 1876
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 15121041756
Email: xingui2022@126.com
Country: China
ProdList: 9979
Advantage: 58

Zhengzhou Guancheng Laboratory equipment Sales

Tel: 0371-88888888 272369594
Fax: QQ:272369594
Email: 2723695949@qq.com
Country: China
ProdList: 4958
Advantage: 50

Chongqing Kangheyuecheng Pharmaceutical Technology Co., Ltd.

Tel: 023-61183015; 13271886913
Email: kangheyuecheng@163.com
Country: China
ProdList: 292
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
Advantage: 58

Shanghai HongMin Pharmaceutical Co., Ltd.

Tel: 13651987816
Fax: -
Email: hongminpharm@163.com
Country: China
ProdList: 2326
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55055611 18137792234
Fax: QQ：3002694073
Email: 3002694073@qq.com
Country: China
ProdList: 9987
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 20284
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

Amel Pharmatech Corporation

Tel: 027-888-4366503
Fax: 888-502-1736
Email: sales@amelpharmatech.com
Country: China
ProdList: 5000
Advantage: 58

Suzhou XiBoli Biotechnology Co., Ltd.

Tel: 17326194005
Email: 1873444526@qq.com
Country: China
ProdList: 496
Advantage: 58

Zhejiang Lianshuo Biotechnology Co., Ltd.

Tel: 18616526224
Email: lianshuo@vip.126.com
Country: China
ProdList: 9607
Advantage: 58

Wuhan Chemwish Technology Co., Ltd

Tel: 027-67849912
Email: sales@chemwish.com
Country: CHINA
ProdList: 10821
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Changzhou Kechem Bio-Scientific Co., LTD.

Tel: 0519-68985668 13685222090
Fax: qq735434464
Email: sales@kechem.cn
Country: China
ProdList: 26028
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Suzhou Daolan Biomedical Technology Co., Ltd.

Tel: 15952404857
Email: sales@dolanpharm.com
Country: China
ProdList: 2919
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

Jiaxing Zhejia Biotechnology Co., LTD

Tel: 0573-85609002 18367600069;
Email: zhejia01@163.com
Country: China
ProdList: 8886
Advantage: 58

Henan Evonik Biotechnology Co. LTD

Tel: 15672878902
Email: hnyingchuang@163.com
Country: China
ProdList: 3905
Advantage: 58

Beijing InnoChem Science & Technology Co., Ltd.

Tel: 15652467323
Email: sales@inno-chem.com.cn
Country: China
ProdList: 8293
Advantage: 58

Hangzhou Hongxi Biomedical Technology Co., LTD

Tel: 18989489206
Email: hoxipharm@163.com
Country: China
ProdList: 4921
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29995
Advantage: 58

Hefei Mokai Pharmaceutical Technology Co., Ltd

Tel: 19355912709
Email: 690231469@qq.com
Country: China
ProdList: 7593
Advantage: 58

Baoji Didu Pharmaceutical and Chemical Co., Ltd

Tel: 029-029-81148929 17791530722
Email: 1049@dideu.com
Country: China
ProdList: 10011
Advantage: 58

Hangzhou Boloko Biotechnology Co., LTD

Tel: 13757158499; 13757158499
Email: bolokobiotech@qq.com
Country: China
ProdList: 3981
Advantage: 58

Shandong Dongde New Materials Co., Ltd

Tel: 15666167041
Email: 15666167041@163.com
Country: China
ProdList: 2999
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

Jinan Yaode Biotechnology Co., Ltd

Tel: 17805033575
Email: baiyu1.618@163.com
Country: China
ProdList: 146
Advantage: 58

Shanghai Yaoheping Biopharmaceutical Technology Co., Ltd

Tel: 021-57540919 13120888836
Email: lily@yhp-biomedicine.com
Country: China
ProdList: 8089
Advantage: 58

Beijing Sunsoly S&T Co.,Ltd

Tel: +8613910445483
Email: amanda@sunsoly.com
Country: China
ProdList: 264
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Shanghai Qiming Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6502
Advantage: 58

Beijing Luyuan Bird Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 15810802415@139.com
Country: CHINA
ProdList: 6750
Advantage: 58

27069-16-5, 5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACIDRelated Search:

5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID 5-METHYL-2-(4-TRIFLUOROMETHOXYPHENYL)-3H-IMIDAZOLE-4-CARBOXYLIC ACID 2-BENZO[1,3]DIOXOL-5-YL-5-METHYL-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 3-(4-ETHOXYPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID 2-(4-METHOXYPHENYL)-5-METHYL-3H-IMIDAZOLE-4-CARBOXYLIC ACID 5-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-2H-PYRAZOLE-3-CARBOXYLIC ACID 3-(4-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 2-(4-METHOXYPHENYL)-5-METHYL-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 5-METHYL-2-(4-TRIFLUOROMETHOXYPHENYL)-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 5-(4-METHOXYPHENYL)-1-PHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID 5-BENZO[1,3]DIOXOL-5-YL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL 3-(4-METHOXYPHENYL)-1-METHYL-1H-PYRAZOLE-5-CARBOXYLATE 5-(3,4-DIMETHOXY-PHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID 5-(2,4-DIMETHOXY-PHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID 3-(2,3-DIHYDROBENZO[B][1,4]DIOXIN-7-YL)-1-(2-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID 3-(2,3-DIHYDROBENZO[B][1,4]DIOXIN-7-YL)-1-(4-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID 3-(2-METHOXYPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 1-(4-METHOXYPHENYL)-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

CHEMBRDG-BB 7270767

3-(4-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBO&

5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid(SALTDATA: FREE)

5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID

5-(4-Methoxyphenyl)-1H-pyrazole-3-carboxylic acid ,97%

5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID ISO 9001：2015 REACH

27069-16-5

Pyrazoles

Heterocyclic Compounds

Building Blocks

Heterocyclic Building Blocks

Pyrazoles