Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H332Harmful if inhaled

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

Org 10172 Chemical Properties,Usage,Production

Originator

Danaparoid sodium,Organon,Netherlands

Uses

Heparinoid; prevention of deep vein thrombosis.

Manufacturing Process

Bovine lung (100 kg) was treated with proteolytic enzymes from pig pancreas. After 15 hours incubation at pH 8.5, 40°C, the mixture was filtered off. The clear filtrate was brought into contact with a strongly basic ion exchanger (QAE Sephadex A50) and stirred for 15 hours. Then the ion exchanger was filtered off and eluted with an aqueous solution of NaCl (200 g/L). Methanol was added to the eluate up to 50% v/v. The resultant precipitate was removed, after which methanol was added to the mother liquor up to 75% v/v. The precipitate was recovered, washed with 100% methanol and dried. The white amorphous powder (22.7 g) obtained had a galactosamine content of 0.45 mmol/g, a glucosamine content of 0.54 mmol/g, an average molecular weight of 6600 with an auxiliary peak at an average of 38,000 (determined with respect to dextrane), an [α]D20 of +34.2°, a sulphur content of 5.7%, a nitrogen content of 2.6%, a content of ionic groups of 3.90 meq/g, a content of sulphamido groups of 0.69 mmol/g and an idose/glucose ratio of 2.1.
Pig intestinal mucous (100 kg) was treated with proteases of Bacillus subtilis at 35°C and pH 8.2 for 24 hours. The mixture was filtered and the clear filtrate was processed in a manner similar to that described above. The yield was 3.2 g of white amorphous powder with a galactosamine content of 0.38 mmol/g, a glucosamine content of 0.82 mmol/g, an average molecular weight of 6100 with an auxiliary peak at an average of 42,000 (determined with respect to dextrane), an [α]D20 of +35.1°, a sulphur content of 5.9%, a nitrogen content of 2.7%, a content of ionic groups of 3.70 meq/g, a content of sulphamido groups of 0.73 mmol/g and an idose/glucose ratio of 1.9.

Therapeutic Function

Antithrombotic