N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine
- Product Name
- N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine
- CAS No.
- 61136-12-7
- Chemical Name
- N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine
- Synonyms
- N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine;D-α-Glutamine, N-(N-acetylnormuramoyl)-L-alanyl-
- CBNumber
- CB91400110
- Molecular Formula
- C18H30N4O11
- Formula Weight
- 478.45
- MOL File
- 61136-12-7.mol
N-Bromosuccinimide Price
- Product number
- API0019250
- Product name
- ALMURTIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.7
- Updated
- 2021/12/16
N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine Chemical Properties,Usage,Production
Uses
Almurtide (nor-MDP), a muramyl dipeptide derivative with anti-inflammatory and anti-tumor activity. Almurtide also shows protective effects against intraperitoneal Pseudomonas aeruginosa infection or intravenously Candida albicans infection in mice. Almurtide also inhibits the carcinogenic Friend leukemia virus[1][2][3].
in vivo
Almurtide (80 mg/kg; once daily for 4 consecutive days; via intraperitoneal, intravenous, or subcutaneous) stimulates macrophages nonspecifically and has anti-infective activity against Listeria monocytogenes. At the same time, it lacks oral activity and is synergistic with Gentamicin (HY-A0276A)[2].
Almurtide (100 μg/mouse; s.c.; once for 2-3 months) prevents erythroleukemia in SJL/J mice caused by low-dose Friend leukemia virus and delays the occurrence of spontaneous breast tumors in RIII/Imr mice[3].
References
[1] Díaz-Eufracio BI, et al. Exploring the chemical space of peptides for drug discovery: a focus on linear and cyclic penta-peptides. Mol Divers. 2018 May;22(2):259-267. DOI:10.1007/s11030-018-9812-9
[2] Fraser-Smith E B, et al. Protective effect of muramyl dipeptide analogs against infections of Pseudomonas aeruginosa or Candida albicans in mice. Infection and immunity, 1981, 34(3): 676-683.
[3] Acevedo H F, et al. Prevention of oncogenic viral infections in mice with CGP 11637, a synthetic muramyl dipeptide analog[J]. Antimicrobial agents and chemotherapy, 1985, 28(5): 589-596.
N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine Preparation Products And Raw materials
Raw materials
Preparation Products
N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine Suppliers
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- 1-631-485-4226; 16314854226
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- Country
- United States
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- 12952
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