Feprazone
- Product Name
- Feprazone
- CAS No.
- 30748-29-9
- Chemical Name
- Feprazone
- Synonyms
- analud;da2370;Zepelin;Grisona;Naloven;Nilatin;Tabrien;FEPRAZONE;prenazone;pheprazone
- CBNumber
- CB9142189
- Molecular Formula
- C20H20N2O2
- Formula Weight
- 320.39
- MOL File
- 30748-29-9.mol
Feprazone Property
- Melting point:
- 156.5° (ethanol)
- Boiling point:
- 459.28°C (rough estimate)
- Density
- 1.1670 (rough estimate)
- refractive index
- 1.5700 (estimate)
- storage temp.
- -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- pka
- 5.09 ± 0.07(at 25℃)
- form
- Solid
- color
- Pale Yellow to Yellow
- CAS DataBase Reference
- 30748-29-9(CAS DataBase Reference)
Safety
- Toxicity
- LD50 in male mice, rats (mg/kg): 408.8, 386.4 i.p.; 1067, >2000 orally (Bianchi, Bonardi)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 20652
- Product name
- Feprazone
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 20652
- Product name
- Feprazone
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $92
- Updated
- 2024/03/01
- Product number
- 20652
- Product name
- Feprazone
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- F285650
- Product name
- Feprazone
- Packaging
- 2.5g
- Price
- $2025
- Updated
- 2021/12/16
- Product number
- FF37355
- Product name
- Feprazone
- Packaging
- 50mg
- Price
- $50
- Updated
- 2021/12/16
Feprazone Chemical Properties,Usage,Production
Originator
Zepelin,De Angeli,Italy,1972
Uses
Feprazone is a anti-inflammatory agent used in the management of inflammatory or degenerative joint diseases.
Definition
ChEBI: Feprazone is an organic molecular entity.
Manufacturing Process
43.8 g (0.237 mol) of hydrazobenzene are added to a solution of sodium
ethylate obtained by dissolving 6.55 g (0.285 mol) of sodium in 125 ml of
anhydrous ethanol. 59.6 g (0.2612 mol) of diethyl 3-methyl-2-butenyl malonate are then added, with stirring, at the reflux temperature.
The reaction mixture is refluxed for 1 hour, then the solvent is slowly distilled
off, the distillation being completed in vacuo. The solid residue so obtained is
dissolved in 400 ml of water and washed with ether. The solution is acidified
with 10% HCl and the 1,2-diphenyl-3,5-dioxo-4-(3'-methyl-2'-butenyl)-
pyrazolidine which separates is purified by crystallization from ethanol (MP
155°C to 156°C).
brand name
Bentudor;Brotazona;Cocresol;Da 2370;Danfenona;Feniprenazone;Fepramole;Golaman;Impremial;Metrazone;Naoven;Nazona;Nessazona;Prenakes;Rangozona;Represil;Solielin;Tbrien;Vapesin;Zontal;Zoontal.
Therapeutic Function
Antiinflammatory
World Health Organization (WHO)
Feprazone, a pyrazolone derivative with antiinflammatory, analgesic and antipyretic activity, was introduced in 1978 for the treatment of rheumatic disorders. As it is structurally related to phenylbutazone it is subjected to rigorously restricted indications by some national regulatory authorities. See WHO comment for phenylbutazone. WHO has been informed that to date feprazone is only available in some 7 countries.
Feprazone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Feprazone manufacturers
- Product
- Feprazone 30748-29-9
- Price
- US $1.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 ton
- Release date
- 2024-08-15
- Product
- Feprazone 30748-29-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2021-07-30
- Product
- Feprazone 30748-29-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-08-29