ChemicalBook > CAS DataBase List > Feprazone

Feprazone

Product Name: Feprazone
CAS No.: 30748-29-9
Chemical Name: Feprazone
Synonyms: analud;da2370;Zepelin;Grisona;Naloven;Nilatin;Tabrien;FEPRAZONE;prenazone;pheprazone
CBNumber: CB9142189
Molecular Formula: C20H20N2O2
Formula Weight: 320.39
MOL File: 30748-29-9.mol

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Feprazone Property

Melting point:: 156.5° (ethanol)
Boiling point:: 459.28°C (rough estimate)
Density: 1.1670 (rough estimate)
refractive index: 1.5700 (estimate)
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
pka: 5.09 ± 0.07(at 25℃)
form: Solid
color: Pale Yellow to Yellow
InChI: InChI=1S/C20H20N2O2/c1-15(2)13-14-18-19(23)21(16-9-5-3-6-10-16)22(20(18)24)17-11-7-4-8-12-17/h3-13,18H,14H2,1-2H3
InChIKey: RBBWCVQDXDFISW-UHFFFAOYSA-N
SMILES: N1(C2=CC=CC=C2)C(=O)C(C/C=C(/C)\C)C(=O)N1C1=CC=CC=C1
CAS DataBase Reference: 30748-29-9(CAS DataBase Reference)

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Safety

Toxicity: LD50 in male mice, rats (mg/kg): 408.8, 386.4 i.p.; 1067, >2000 orally (Bianchi, Bonardi)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20652
Product name: Feprazone
Purity: ≥98%
Packaging: 25mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 20652
Product name: Feprazone
Purity: ≥98%
Packaging: 50mg
Price: $92
Updated: 2024/03/01

Cayman Chemical

Product number: 20652
Product name: Feprazone
Purity: ≥98%
Packaging: 100mg
Price: $172
Updated: 2024/03/01

TRC

Product number: F285650
Product name: Feprazone
Packaging: 2.5g
Price: $2025
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FF37355
Product name: Feprazone
Packaging: 50mg
Price: $50
Updated: 2021/12/16

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Feprazone Chemical Properties,Usage,Production

Originator

Zepelin,De Angeli,Italy,1972

Uses

Feprazone is a anti-inflammatory agent used in the management of inflammatory or degenerative joint diseases.

Definition

ChEBI: Feprazone is an organic molecular entity.

Manufacturing Process

43.8 g (0.237 mol) of hydrazobenzene are added to a solution of sodium ethylate obtained by dissolving 6.55 g (0.285 mol) of sodium in 125 ml of anhydrous ethanol. 59.6 g (0.2612 mol) of diethyl 3-methyl-2-butenyl malonate are then added, with stirring, at the reflux temperature.
The reaction mixture is refluxed for 1 hour, then the solvent is slowly distilled off, the distillation being completed in vacuo. The solid residue so obtained is dissolved in 400 ml of water and washed with ether. The solution is acidified with 10% HCl and the 1,2-diphenyl-3,5-dioxo-4-(3'-methyl-2'-butenyl)- pyrazolidine which separates is purified by crystallization from ethanol (MP 155°C to 156°C).

brand name

Bentudor;Brotazona;Cocresol;Da 2370;Danfenona;Feniprenazone;Fepramole;Golaman;Impremial;Metrazone;Naoven;Nazona;Nessazona;Prenakes;Rangozona;Represil;Solielin;Tbrien;Vapesin;Zontal;Zoontal.

Therapeutic Function

Antiinflammatory

World Health Organization (WHO)

Feprazone, a pyrazolone derivative with antiinflammatory, analgesic and antipyretic activity, was introduced in 1978 for the treatment of rheumatic disorders. As it is structurally related to phenylbutazone it is subjected to rigorously restricted indications by some national regulatory authorities. See WHO comment for phenylbutazone. WHO has been informed that to date feprazone is only available in some 7 countries.

Feprazone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Feprazone manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Feprazone 30748-29-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-03-11

Hebei Chuanghai Biotechnology Co,.LTD

Product: Feprazone 30748-29-9
Price: US $1.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-08-15

Dideu Industries Group Limited

Product: Feprazone 30748-29-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-06-15

30748-29-9, FeprazoneRelated Search:

Linezolid Diniconazole Uniconazole 3-Methyl-1-butene 3,3-Dimethylallyl bromide Bendazol Phenprobamate Etodolac Flumazenil LAPPACONITINE(P) (+/-)-Sulfinpyrazone Acetaminophen FEPRAZONE Phenidone 1,2-Diphenylhydrazine 1-Phenyl-4-methyl-3-pyrazolidone 1,2-DIPHENYL-PYRAZOLIDINE-3,5-DIONE Feprazone

4-(2-isopentenyl)-1,2-diphenyl-3,5-pyrazolidinedione

Zepelin

1,2-diphenyl-4-(3-methyl-2-butenyl)-3,5-pyrazolidinedione

1,2-diphenyl-4-(3-methyl-2-butenyl)-5-pyrazolidinedione

fenilprenazone

methrazone

phenylprenazone

pheprazone

FEPRAZONE

4-(Aminomethyl)cyclohexanecarboxylic acid Solution, 100ppm

4-(3-methyl-2-butenyl)-1,2-diphenyl-3,5-pyrazolidinedione

4-(3-methyl-2-butenyl)-1,2-diphenyl-5-pyrazolidinedione

4-(beta-isoamylenyl)-1,2-diphenyl-3,5-pyrazolidinedione

4-prenyl-1,2-diphenyl-3,5-dioxopyrazolidine

4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione

analud

da2370

4-(3-Methylbut-2-en-1-yl)-1,2-diphenylpyrazolidine-3,5-dione

Grisona

Naloven

Nilatin

Tabrien

prenazone

4-(3-methylbut-2-enyl)-1,2-diphenylpyrazolidine-3,5-dione

Metherazone

Metherazone,Prenazone

3,5-Pyrazolidinedione, 4-(3-methyl-2-buten-1-yl)-1,2-diphenyl-

Feprazone USP/EP/BP

Feprazone in Acetonitrile

Feprazone, 10 mM in DMSO

30748-29-9

C20H20N2O2

30748-29-9