Bendazol
- Product Name
- Bendazol
- CAS No.
- 621-72-7
- Chemical Name
- Bendazol
- Synonyms
- dibasol;dibazol;bendazo;E,TECH.;BENDAZOL;DIBAZOLE;bendazole;DibazoluM;Ground bar;tromasedan
- CBNumber
- CB8176220
- Molecular Formula
- C14H12N2
- Formula Weight
- 208.26
- MOL File
- 621-72-7.mol
Bendazol Property
- Melting point:
- 187°
- Boiling point:
- 337.46°C (rough estimate)
- Density
- 1.1345 (rough estimate)
- refractive index
- 1.6152 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 11.77±0.10(Predicted)
- color
- Crystals or needles from benzene
- CAS DataBase Reference
- 621-72-7(CAS DataBase Reference)
Safety
- HazardClass
- IRRITANT
- Toxicity
- LD50 orl-mus: 100 mg/kg FRZKAP (1),44,83
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- S358258
- Product name
- 2-BENZYLBENZIMIDAZOLE,TECH.
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $179
- Updated
- 2024/03/01
- Product number
- B411025
- Product name
- 2-Benzyl-1H-benzimidazole
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C6634
- Product name
- Bendazol
- Packaging
- 500mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-8010
- Product name
- Bendazol
- Purity
- 99.45%
- Packaging
- 500mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FB39600
- Product name
- Bendazol
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
Bendazol Chemical Properties,Usage,Production
Uses
Bendazol is an orally effective antihypertensive agent. Bendazol acts directly on vascular smooth muscle to dilate blood vessels and reduce peripheral resistance, thereby improving blood circulation. Bendazol significantly inhibits the development of myopia in rabbit models. Bendazol can regulate kidney function by increasing the activity of NO synthase in the rat model of nephrogenic hypertension. In addition, Bendazol has an effect on sexual behavior and spermatogenesis in male rats[1][2][3].
Definition
ChEBI: Bendazol is a member of benzimidazoles.
Safety Profile
Poison by ingestion andintraperitoneal routes. Moderately toxic by subcutaneousroute. Experimental reproductive effects. When heated todecomposition it emits toxic fumes of NOx.
in vivo
Bendazol (1%; Eye drops; Four times daily for 6 weeks) significantly inhibits the development of myopia and down-regulates the expression of HIF-1α in experimental myopia rabbit models[1].
Bendazol (0.1 mg/kg; Intraperitoneal injection; 2 weeks) regulates kidney function by increasing the activity of NO synthase in the rat model of nephrogenic hypertension[2].
| Animal Model: | New Zealand white rabbits aged 3 weeks old with experimental myopia[1] |
| Dosage: | 1% |
| Administration: | Eye drops; Four times daily for 6 weeks |
| Result: | Inhibited the progression of form-deprivation myopia. Suppressed the upregulation of HIF-1α. |
| Animal Model: | Paraformaldehyde (HY-Y0333) treated mature random-bred male rats (250-280 g)[2] |
| Dosage: | 0.1 mg/kg |
| Administration: | Intraperitoneal injection (i.p.); 2 weeks |
| Result: | Remained NADPH diaphorase activity in PT epitheliocytes near the control level throughout the experiment; Gradually increased NADPH diaphorase activity in DT epitheliocytes to the control level throughout the experiment. Enhanced NADPH diaphorase activity and maintained it elevated in renal glomeruli throughout the experiment; Increased NADPH diaphorase in the collecting tubules, but thereupon it declined to the control level at the end of experimental. Insignificant enhanced of NOS activity in PT epitheliocytes observed on postinjection week 1 can somewhat contribute to upregulation of natriuresis and diuresis. |
IC 50
HIF-1α
References
[1] Tong L, et al. Topical bendazol inhibits experimental myopia progression and decreases the ocular accumulation of HIF-1α protein in young rabbits. Ophthalmic Physiol Opt. 2020 Sep;40(5):567-576. DOI:10.1111/opo.12717
[2] Eliseeva EV, et al. Effect of Hypotensive Drugs on Dynamics of Nitroxide-Producing Renal Function in Rats with Nephrogenic Hypertension. Bull Exp Biol Med. 2017 Jan;162(3):357-361. DOI:10.1007/s10517-017-3615-3
[3] Kuzubova EA, et al. [Effect of dibazol (bendazol) on the generative function in rats]. Eksp Klin Farmakol. 2007 Mar-Apr;70(2):37-9. PMID:17523449
Bendazol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Bendazol manufacturers
- Product
- Bendazol 621-72-7
- Price
- US $10.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-29
- Product
- Bendazol 621-72-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98
- Supply Ability
- 1000
- Release date
- 2025-01-17
- Product
- Penconazole 621-72-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2023-03-15