ChemicalBook > CAS DataBase List > 3,4,5-Tribromopyrazole

3,4,5-Tribromopyrazole

Product Name
3,4,5-Tribromopyrazole
CAS No.
17635-44-8
Chemical Name
3,4,5-Tribromopyrazole
Synonyms
3,4,5-TRIBROMO-1H-PYRAZOLE;1H-Pyrazole, 3,4,5-tribromo-;3,4,5-Tribromopyrazol;3,4,5-TRIBROMOPYRAZOLE;3,4,5-Tribromo-1H-pyrazoL;3,4,5-Tribromopyrazole, 97+%;3,4,5-TribroMo-1H-pyrazole, 97%, 97%
CBNumber
CB9142417
Molecular Formula
C3HBr3N2
Formula Weight
304.77
MOL File
17635-44-8.mol
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3,4,5-Tribromopyrazole Property

Melting point:
190-192°C
Boiling point:
381.5±37.0 °C(Predicted)
Density 
2.782±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Chloroform, Methanol
pka
6.47±0.50(Predicted)
form 
Solid
color 
White to Off-White
Water Solubility 
Insoluble in water. Soluble in Chloroform.
BRN 
113501
InChI
InChI=1S/C3HBr3N2/c4-1-2(5)7-8-3(1)6/h(H,7,8)
InChIKey
TXQKCKQJBGFUBF-UHFFFAOYSA-N
SMILES
N1C(Br)=C(Br)C(Br)=N1
CAS DataBase Reference
17635-44-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37
RIDADR 
UN2811
HazardClass 
6.1
HS Code 
29331990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S940429
Product name
3,4,5-TRIBROMO-1H-PYRAZOLE
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$185
Updated
2025/07/31
Sigma-Aldrich
Product number
S940429
Product name
3,4,5-TRIBROMO-1H-PYRAZOLE
Purity
Aldrich
Packaging
50mg
Price
$179
Updated
2024/03/01
TCI Chemical
Product number
T2777
Product name
3,4,5-Tribromopyrazole
Purity
>98.0%(GC)
Packaging
5g
Price
$52
Updated
2025/07/31
TCI Chemical
Product number
T2777
Product name
3,4,5-Tribromopyrazole
Purity
>98.0%(GC)
Packaging
25g
Price
$208
Updated
2025/07/31
TRC
Product number
T772750
Product name
3,4,5-Tribromopyrazole
Packaging
50g
Price
$335
Updated
2021/12/16
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3,4,5-Tribromopyrazole Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

2,4,5-Tribromoimidazole(2,4,5-TBI) on condensation with sugar precursors yields 2,4,5-TBI nucleosides. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Uses

3,4,5-Tribromopyrazole is used in the preparation of 1-aryl-4-substituted piperazine CCR1 antagonists for the treatment of inflammation and immune disorders.

Synthesis

288-13-1

17635-44-8

Step A: 1H-pyrazole (6.95 g, 0.1 mol) and sodium hydroxide (16 g, 0.4 mol) were dissolved in 400 mL of water, and bromine (48 g, 0.3 mol) was added slowly and dropwise with stirring over 1 hour. The reaction mixture was continued to be stirred for 1 h. The reaction mixture was filtered and the filter cake was washed with deionized water and dried to give 3,4,5-tribromo-1H-pyrazole (25.2 g, 81% yield). Mass spectral analysis showed m/z 302.9 [M + H]+.

References

[1] Journal of the Chemical Society, Dalton Transactions, 2002, # 11, p. 2297 - 2301
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 13, p. 6070 - 6085
[3] Patent: US9617268, 2017, B2. Location in patent: Page/Page column 414; 415
[4] Journal of Organic Chemistry, 1986, vol. 51, # 24, p. 4656 - 4660
[5] Tetrahedron, 2007, vol. 63, # 1, p. 56 - 61

3,4,5-Tribromopyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4,5-Tribromopyrazole Suppliers

Belgium 1 Canada 1 China 157 Germany 3 India 15 Japan 1 United Kingdom 5 United States 19 Global 202
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View Lastest Price from 3,4,5-Tribromopyrazole manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
3,4,5-Tribromopyrazole 17635-44-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-01
Hebei Yanxi Chemical Co., Ltd.
Product
3,4,5-Tribromopyrazole 17635-44-8
Price
US $30.00-10.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-11-16
Hangzhou ICH Biofarm Co., Ltd
Product
3,4,5-Tribromopyrazole 17635-44-8
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
99.0%min
Supply Ability
200kg
Release date
2023-12-13

17635-44-8, 3,4,5-TribromopyrazoleRelated Search:

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Pyrazole Pyraclostrobin Zolpidem tartrate Metazachlor Zolpidem 1-(4-NITROPHENYL)-3,4,5-TRIBROMOPYRAZOLE 3,4,5-Tribromopyrazole N1-[4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)PHENYL]ACETAMIDE N1-[2-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)ETHYL]-4-CHLOROBENZENE-1-SULFONAMIDE N-(4-CHLOROPHENYL)-N'-[2-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)ETHYL]THIOUREA N1,N1-DIMETHYL-N'1-[2-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)ETHYL]ETHANIMIDAMIDE 2-([4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)ANILINO]METHYLIDENE)MALONONITRILE N-(2-FLUOROBENZOYL)-N'-[4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)PHENYL]UREA DIETHYL 2-([4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)ANILINO]METHYLIDENE)MALONATE 4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)ANILINE N1-[2-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)ETHYL]-4-CHLOROBENZAMIDE N-(4-CHLOROPHENYL)-N'-[4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)PHENYL]UREA

  • 3,4,5-TRIBROMOPYRAZOLE
  • 3,4,5-TRIBROMO-1H-PYRAZOLE
  • 3,4,5-Tribromopyrazole, 97+%
  • 3,4,5-Tribromopyrazol
  • 3,4,5-TribroMo-1H-pyrazole, 97%, 97%
  • 3,4,5-Tribromo-1H-pyrazoL
  • 1H-Pyrazole, 3,4,5-tribromo-
  • 17635-44-8
  • Piperidines
  • Heterocyclic Compounds
  • Heterocycles