2-NITRO-1-PROPANOL

2-NITRO-1-PROPANOL Property

Melting point:

-20°C (estimate)

Boiling point:

72-74 °C/1 mmHg (lit.)

Density 

1.185 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.439(lit.)

Flash point:

212 °F

storage temp. 

2-8°C

pka

7.36±0.13(Predicted)

form 

liquid (clear)

color 

clear green-yellow

Water Solubility 

Slightly soluble in water.

BRN 

1748592

Safety

Safety Statements 

23-24/25

WGK Germany 

3

HS Code 

29055900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H228Flammable solid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

2-NITRO-1-PROPANOL Chemical Properties,Usage,Production

Uses

2-Nitro-1-propanol is used in improved synthesis of 2,2,2-trinitroethyl ethers, inhibits methane production during in vitro ruminal fermentation.

Uses

2-Nitro-1-propanol was used in improved synthesis of 2,2,2-trinitroethyl ethers.

Uses

2-Nitro-1-propanol is used in an improved synthesis of 2,2,2-trinitroethyl ethers.

Definition

ChEBI: 2-nitro-1-propanol is a C-nitro compound.

General Description

2-Nitro-1-propanol inhibits methane production during in vitro ruminal fermentation. It is a useful antimicrobial supplement which reduces carriage of certain food-borne pathogens in animals.

Synthesis

To a three-necked round-bottomed flask equipped with a stirring magnet, condenser tube, nitrogen inlet and outlet, and constant-pressure dropping funnel, nitroethane (10 g, 0.13 mol) and triethylamine (0.3 g, 10 mol%) were added sequentially. The resulting light yellow solution was stirred for 10 min and then 37% aqueous formaldehyde solution (21.6 g, 0.27 mol) was added slowly and dropwise over a period of 1 hr. The reaction mixture was stirred continuously at room temperature for 24 h, during which the progress of the reaction was monitored periodically by gas chromatography (GC) to confirm complete conversion of the feedstock. The reaction was terminated after 24 hours and the volatile components were removed using a rotary evaporator. A yellow solution was obtained, which was analyzed by GC to confirm the presence of two target products (2-nitro-1-propanol and 2-nitro-2-methyl-1,3-propanediol). The mixture could be used directly in the subsequent reaction without further purification.

References

[1] Patent: EP2468713, 2012, A1. Location in patent: Page/Page column 3-4