ChemicalBook > CAS DataBase List > α-(p-Aminophenyl)butyric acid

α-(p-Aminophenyl)butyric acid

Product Name: α-(p-Aminophenyl)butyric acid
CAS No.: 29644-97-1
Chemical Name: α-(p-Aminophenyl)butyric acid
Synonyms: YD201;NSC 27530;Aids019033;Aids-019033;Indobufen Impurity 7;Indobufen Impurity D;Indobufen Impurity 16;Indobufen impurities842;Indoibufen intermediate 1;α -(p-aMinophenyl)butyriacid
CBNumber: CB91451400
Molecular Formula: C10H13NO2
Formula Weight: 179.22
MOL File: 29644-97-1.mol

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α-(p-Aminophenyl)butyric acid Property

Melting point:: 142-143℃
Boiling point:: 354.6±17.0 °C(Predicted)
Density: 1.171±0.06 g/cm3 (20 ºC 760 Torr)
vapor pressure: 13-18hPa at 20-25℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 4.01±0.10(Predicted)
form: Solid:particulate/powder
Appearance: White to off-white Solid
InChI: InChI=1S/C10H13NO2/c1-2-9(10(12)13)7-3-5-8(11)6-4-7/h3-6,9H,2,11H2,1H3,(H,12,13)
InChIKey: WAPLXGPARWRGJO-UHFFFAOYSA-N
SMILES: C1(C=CC(N)=CC=1)C(CC)C(=O)O
LogP: -1.3 at 19.8℃ and pH7
Surface tension: 75.21mN/m at 1g/L and 20℃

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Safety

Toxicity: mouse,LD50,intraperitoneal,1180mg/kg (1180mg/kg),Farmaco, Edizione Scientifica. Vol. 13, Pg. 286, 1958.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A615540
Product name: 2-(4-Aminophenyl)butanoicacid
Packaging: 500mg
Price: $675
Updated: 2021/12/16

AK Scientific

Product number: 3036AB
Product name: 2-(4-Aminophenyl)butanoicacid
Packaging: 1g
Price: $500
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0984997
Product name: 2-(4-AMINO-PHENYL)-BUTYRIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $502.38
Updated: 2021/12/16

Acints

Product number: SB-14K-002
Product name: 2-(4-Amino-phenyl)-butyricacid
Purity: 95%+
Packaging: 5g
Price: $862.75
Updated: 2021/12/16

Ambeed

Product number: A155756
Product name: 2-(4-Aminophenyl)butanoicacid
Purity: 95%
Packaging: 100mg
Price: $29
Updated: 2021/12/16

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α-(p-Aminophenyl)butyric acid Chemical Properties,Usage,Production

Pharmaceutical Applications

α-(p-Aminophenyl)butyric acid can be used as a ligand for the development of GABA receptor modulators, which are crucial in the treatment of neurological disorders. Its structural similarity to GABA allows it to interact with GABA receptors, potentially modulating their activity and offering therapeutic benefits.

Synthesis

7463-53-8

29644-97-1

2-(4-Nitrophenyl)butyric acid (10.0 g, 47.8 mmol) and carbon-loaded palladium catalyst (0.25 g) were suspended in methanol (100 mL). The reaction mixture was stirred overnight at room temperature and 1 atm hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the diatomaceous earth was washed with methanol (50 mL). The filtrates were combined and concentrated using a rotary evaporator. Water (200 mL) was added to the concentrate and recrystallized. The mixture was cooled in an ice bath to precipitate a pink solid product. The solid was collected by vacuum filtration and dried under vacuum to give 5.8 g of 2-(4-aminophenyl)butyric acid in 68% yield. The product was characterized by the following data: NMR (400 MHz, DMSO-d6) δ 11.88 (s, 1H, COOH), 6.73 (d, J = 8.4 Hz, 2H, ArH), 6.31 (d, J = 8.4 Hz, 2H, ArH), 4.77 (s, 2H, NH2), 2.98 (t, J = 7.5 Hz, 1H, CH). 1.68 (m, 1H, CH2), 1.39 (m, 1H, CH2), 0.62 (t, J = 7.3 Hz, 3H, CH3); MS (ESI) m/z 202.1 ([M+Na]+).

References

[1] Patent: WO2017/205451, 2017, A1. Location in patent: Paragraph 0293
[2] Bulletin de la Societe Chimique de France, 1927, vol. <4> 41, p. 451
[3] Patent: US5214191, 1993, A
[4] Patent: CN106631974, 2017, A. Location in patent: Paragraph 0028; 0029; 0031; 0032; 0033

α-(p-Aminophenyl)butyric acid Preparation Products And Raw materials

Raw materials

Benzeneacetonitrile Bromoethane 2-Phenylbutyric acid

Preparation Products

Indobufen

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View Lastest Price from α-(p-Aminophenyl)butyric acid manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Benzeneacetic acid,4-amino-a-ethyl- 29644-97-1
Price: US $22.00-88.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50kg
Release date: 2025-06-25

Henan Aochuang Chemical Co.,Ltd.

Product: α-(p-Aminophenyl)butyric acid 29644-97-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-09

Shaanxi Dideu New Materials Co. Ltd

Product: Benzeneacetic acid,4-amino-a-ethyl- 29644-97-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-04-02

29644-97-1, α-(p-Aminophenyl)butyric acidRelated Search:

2-(4-NITROPHENYL)BUTYRIC ACID Indobufen Phthalic acid CIS-BUTENEDIOIC ANHYDRIDE Benzeneacetic acid, α-ethyl-2-nitro- Indobufen Impurity 9 Indobufen Impurity 23 Benzeneacetic acid, 4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-α-ethyl-, ethyl ester 2-[4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]butyric acid Benzeneacetonitrile, 4-amino-α-ethyl- Indobufen Impurity A Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-ethyl-, ethyl ester ethyl 2-(4-nitrophenyl)butanoate Benzeneacetic acid, α-ethyl-3-nitro- Benzeneacetonitrile, α-ethyl-2-nitro- Benzeneacetonitrile, α-ethyl-4-nitro- Indobufen Impurity 2 4-Nitrophenylacetic acid

2-(p-aminophenyl)-butyric acid

2-(4-aminophenyl)butanoic acid

α-(p-Aminophenyl)butyric acid 2-(p-aminophenyl)-butyric acid

2-(4-Aminophenyl)butyric acid

1-alpha-(p-Aminophenyl)butyric acid

Aids019033

Aids-019033

Butyric acid, 2-(p-aminophenyl)-

NSC 27530

α -(p-aMinophenyl)butyriacid

Indobufen Impurity 7

Indobufen Impurity D

Indobufen Impurity 16

α-(p-Aminophenyl)butyric acid

Indobufen impurities842

Ethanol,2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-,6-methylbenzenesulfonate

Indoibufen intermediate 1

YD201

Benzeneacetic acid,4-amino-a-ethyl-

29644-97-1