4-ethoxy-1,1,1-trichloro-3-buten-2-one
- Product Name
- 4-ethoxy-1,1,1-trichloro-3-buten-2-one
- CAS No.
- 83124-74-7
- Chemical Name
- 4-ethoxy-1,1,1-trichloro-3-buten-2-one
- Synonyms
- Regadenoson Impurity 14;1,1,1-Trichloro-4-ethoxy-...;4-ethoxy-1,1,1-trichloro-3-buten-2-one;1-Ethoxy-4,4,4-trichloro-3-oxo-1-butene;3-Buten-2-one, 1,1,1-trichloro-4-ethoxy-;(3E)-1,1,1-Trichloro-4-ethoxy-3-buten-2-one;4-ethoxy-1,1,1-trichloro-3-buten-2-one ISO 9001：2015 REACH
- CBNumber
- CB91457154
- Molecular Formula
- C6H7Cl3O2
- Formula Weight
- 217.48
- MOL File
- 83124-74-7.mol
4-ethoxy-1,1,1-trichloro-3-buten-2-one Property
- Boiling point:
- 200℃
- Density
- 1.368
- Flash point:
- 72℃
- InChI
- InChI=1S/C6H7Cl3O2/c1-2-11-4-3-5(10)6(7,8)9/h3-4H,2H2,1H3
- InChIKey
- VKNLVLNOHCTKII-UHFFFAOYSA-N
- SMILES
- C(Cl)(Cl)(Cl)C(=O)C=COCC
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 4999AJ
- Product name
- 1,1,1-Trichloro-4-ethoxy-but-3-en-2-one
- Packaging
- 1g
- Price
- $126
- Updated
- 2021/12/16
- Product number
- 4999AJ
- Product name
- 1,1,1-Trichloro-4-ethoxy-but-3-en-2-one
- Packaging
- 5g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- HCH0050138
- Product name
- 1,1,1-TRICHLORO-4-ETHOXYBUT-3-EN-2-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.57
- Updated
- 2021/12/16
- Product number
- CD13009704U
- Product name
- 4-Ethoxy-1,1,1-trichloro-3-buten-2-one
- Purity
- 97%
- Packaging
- 10g
- Price
- $108
- Updated
- 2021/12/16
- Product number
- CD13009704U
- Product name
- 4-Ethoxy-1,1,1-trichloro-3-buten-2-one
- Purity
- 97%
- Packaging
- 25g
- Price
- $216
- Updated
- 2021/12/16
4-ethoxy-1,1,1-trichloro-3-buten-2-one Chemical Properties,Usage,Production
Synthesis
109-92-2
76-02-8
83124-74-7
Under nitrogen protection, 218.4 g (1.2 mol) of trichloroacetyl chloride was added to a dry round-bottomed flask and the flask was cooled to 0 °C in an ice bath. Subsequently, 172.8 g (2.4 mol) of ethyl vinyl ether was slowly added dropwise to the flask and the reaction temperature was maintained at 0 °C. The reaction mixture was stirred thoroughly under nitrogen atmosphere. After that, the reaction system was slowly warmed to 30 °C and stirring was continued at this temperature for 10 hours to ensure complete reaction. After completion of the reaction, the reaction mixture was refluxed for 3 hours. Finally, the product was purified by distillation under reduced pressure to afford 247.2 g of 1,1,1-trichloro-4-ethoxy-3-buten-2-one as a pale yellow oil (boiling point 117-119 °C, pressure 13 mmHg) in 96.5% yield.
References
[1] Patent: CN107056608, 2017, A. Location in patent: Paragraph 0023; 0024
[2] Chemische Berichte, 1982, vol. 115, p. 2766 - 2782
[3] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 1, p. 254 - 257
[4] Patent: CN105503878, 2016, A. Location in patent: Paragraph 0010
[5] Synlett, 2008, # 11, p. 1684 - 1686
4-ethoxy-1,1,1-trichloro-3-buten-2-one Preparation Products And Raw materials
Raw materials
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View Lastest Price from 4-ethoxy-1,1,1-trichloro-3-buten-2-one manufacturers
- Product
- 4-ethoxy-1,1,1-trichloro-3-buten-2-one 83124-74-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-09
- Product
- 4-ethoxy-1,1,1-trichloro-3-buten-2-one 83124-74-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-08-06