ChemicalBook > CAS DataBase List > Boc-3-amino-2,2-dimethyl-propionic acid

Boc-3-amino-2,2-dimethyl-propionic acid

Product Name
Boc-3-amino-2,2-dimethyl-propionic acid
CAS No.
180181-02-6
Chemical Name
Boc-3-amino-2,2-dimethyl-propionic acid
Synonyms
3-((tert-Butoxycarbonyl)aMino)-2,2-diMethylpropanoic acid;N-Boc-3-Amino-2,2-dimethyl-propi;3-(Boc-amino)-2,2-dimethylpropionic;3-BOCAMINO-2,2-DIMETHYL-PROPIONIC ACID;Boc-3-amino-2,2-dimethyl-propionic acid;N-Boc-3-amino-2,2-dimethylpropionic acid;3-(Boc-amino)-2,2-dimethylpropanoic acid;2,2-Dimethyl-β-alanine-N-(tert-butoxycarbonyl);3-(tert-butoxycarbonyl)-2,2-dimethylpropanoic acid;tert-butyl 3-allyl-3-hydroxyazetidine-41-carboxylate
CBNumber
CB91466600
Molecular Formula
C10H19NO4
Formula Weight
217.26
MOL File
180181-02-6.mol
More
Less

Boc-3-amino-2,2-dimethyl-propionic acid Property

Boiling point:
346.5±25.0 °C(Predicted)
Density 
1.082±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
powder
pka
4.61±0.10(Predicted)
Appearance
White to off-white Solid
More
Less

Safety

HS Code 
29225090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PH017156
Product name
2-(Phenylsulfanyl)nicotinoyl chloride
Purity
AldrichCPR
Packaging
500MG
Price
$75.3
Updated
2022/05/15
TRC
Product number
D461830
Product name
2,2-Dimethyl-β-alanine-N-(tert-butoxycarbonyl)
Packaging
250mg
Price
$140
Updated
2021/12/16
Usbiological
Product number
265958
Product name
Boc-3-amino-2,2-dimethyl-propionic acid
Packaging
250mg
Price
$410
Updated
2021/12/16
TRC
Product number
D461830
Product name
2,2-Dimethyl-β-alanine-N-(tert-butoxycarbonyl)
Packaging
2.5g
Price
$1020
Updated
2021/12/16
AK Scientific
Product number
W3912
Product name
3-((tert-Butoxycarbonyl)amino)-2,2-dimethylpropanoicacid
Packaging
10g
Price
$1089
Updated
2021/12/16
More
Less

Boc-3-amino-2,2-dimethyl-propionic acid Chemical Properties,Usage,Production

Uses

2,2-Dimethyl-β-alanine-N-(tert-butoxycarbonyl) is used as a reactant in the synthesis of cryptophycin anticancer agents.

Synthesis

19036-43-2

24424-99-5

180181-02-6

Example 6: Synthesis of 3-(tert-butoxycarbonylamino)-2,2-dimethylpropionic acid (19) [00156] Under argon protection, 3-amino-2,2-dimethylpropionic acid (18) (1.2 g, 10.2 mmol), di-tert-butyl dicarbonate (Boc anhydride) (2.3 g, 10.2 mmol) and N,N-diisopropylethylamine (DIPEA) (1.85 mL, 10.23 mmol) were dissolved in N,N-dimethylformamide (DMF) (30 mL) in N,N-dimethylformamide (DMF) and the reaction was stirred at 60°C for 16 hours. After completion of the reaction, the reaction mixture was concentrated under reduced pressure, the residue was dissolved in ethyl acetate (EtOAc), washed with saturated ammonium chloride (NH4Cl) solution, and the organic phase was concentrated again under reduced pressure to afford the title compound 3-(tert-butoxycarbonylamino)-2,2-dimethylpropanoic acid (19) (2.0 g, 91% yield). 1H NMR (300 MHz, CDCl3) δ 1.33 (s, 6H), 1.37 (s, 9H), 2.69 (s, 2H).

References

[1] Patent: WO2011/32291, 2011, A1. Location in patent: Page/Page column 47
[2] Journal of Organic Chemistry, 2010, vol. 75, # 20, p. 6953 - 6960
[3] Patent: US2015/210635, 2015, A1. Location in patent: Paragraph 0483-0485
[4] Patent: EP2865664, 2015, A1. Location in patent: Paragraph 0105; 0106
[5] Tetrahedron Letters, 2007, vol. 48, # 47, p. 8277 - 8280

Boc-3-amino-2,2-dimethyl-propionic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Boc-3-amino-2,2-dimethyl-propionic acid Suppliers

China 70 India 1 United Kingdom 1 United States 6 Global 78
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Wuhan Kaymke Chemical Co., Ltd.,
Tel
027-027-87342388 18086026008
Fax
027-87342388
Email
sales@kaymke.com
Country
China
ProdList
3731
Advantage
55
Porse Fine Chemical Co.,LTD
Tel
20-66003216 18666003216
Fax
+86-20-28069063
Email
info@porsefinechemical.com
Country
China
ProdList
1941
Advantage
62
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Shanghai TBBMed Co.,Ltd
Tel
021-50498136 13564881053
Fax
021-50498136
Email
products@tbbmed.com
Country
China
ProdList
184
Advantage
55
JW & Y Pharmlab Co., Ltd.
Tel
021-64340559 13651849907;
Fax
021- 64345308
Email
xinyu_shi@jwypharmlab.com.cn
Country
China
ProdList
12000
Advantage
58
Shanghai GL Peptide Ltd.
Tel
+86-21-61263340; 17609490614 13764994101
Fax
021-61263399
Email
fisherwang@glschina.com
Country
China
ProdList
8258
Advantage
55
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
Sales@changyanchem.cn
Country
China
ProdList
5001
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-55629727 13323845623
Fax
037155629727
Email
2885676761@qq.com
Country
China
ProdList
10109
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
16027
Advantage
58
SHANGHAI FDC-CHEMICAL CO.,LTD
Tel
021-61469567 13482353728
Fax
021-61161605
Email
sales@fdc-chemical.com
Country
China
ProdList
9721
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Yujinpharma(Tianjin) Technology Co.,Ltd.
Tel
13370351217 kungfu1217@1
Fax
QQ1400885609
Email
kungfu1217@163.com
Country
China
ProdList
2720
Advantage
58
Shanghai SPAR pharmaceutical technology co., LTD
Tel
021-000000
Email
admin@jingshipharmatech.com
Country
China
ProdList
9853
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Cool Pharm, Ltd
Tel
021-58581007 18019463053
Fax
021-50966098
Email
sales@coolpharm.com
Country
China
ProdList
12878
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
ROSEWA HOLDING GROUP CO.,LIMITED
Tel
+86-023-62871537
Email
sales@rosewachem.com
Country
China
ProdList
2803
Advantage
58
Nanjing Asfam Pharmaceutical Technology Co., Ltd.
Tel
025-58867862 18751812725
Fax
02558867862
Email
sales@ace-pharm.com
Country
China
ProdList
1985
Advantage
58
Chengdu Feibai Pharmaceutical Co., Ltd.
Tel
028-84641798 18782128315
Email
3302391190@qq.com
Country
China
ProdList
9800
Advantage
55
Shanghai zhigan biotechnology co., LTD
Tel
Email
zhiqianbio@126.com
Country
China
ProdList
19778
Advantage
58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
Tel
18081075745
Email
chemflowtech@sina.com
Country
China
ProdList
1886
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
HUNAN CHEMFISH SCIENTIFIC CO.,LTD
Tel
+86-0731-85567275 13298656710
Fax
QQ:3554193828
Email
sales05@chemfish.com
Country
China
ProdList
7448
Advantage
58
Binhai gill polypeptide co. LTD
Tel
021-61263389 13524856427
Fax
WeChat630417570
Email
Joetang@glschina.com
Country
China
ProdList
10000
Advantage
58
Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd
Tel
037188900765 18037465274
Fax
QQ3430974218
Email
enyawanglei@sina.cn
Country
China
ProdList
13966
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39927
Advantage
58
Jiangsu Hongmin Pharmaceutical Co., Ltd.
Tel
18221292452
Email
fannieliu@glschina.com
Country
China
ProdList
6798
Advantage
58
Zhengzhou anmousse chemical products co. LTD
Tel
0371-55289822 18737195735
Fax
QQ:483339295
Email
483339295@qq.com
Country
China
ProdList
7587
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49312
Advantage
58
Fuxin Pharmaceutical
Tel
+86-021-021-50872116 +8613122107989
Email
contact@fuxinpharm.com
Country
China
ProdList
10000
Advantage
58
Huzhou fuhe Rui biological medicine co., ltd
Tel
13626726938
Country
China
ProdList
791
Advantage
58
Gill polypeptide biopharmaceutical (dalian) co., LTD
Tel
021-61263455 13167021076
Email
amy@glschina.com
Country
China
ProdList
9736
Advantage
58
Jiaxing Hengrui Biotechnology Co. LTD
Tel
0573-0573-82672231 13757365595
Fax
QQ：715584339
Email
regen_chemical1@163.com
Country
China
ProdList
4839
Advantage
58
Advanced chemblocks inc
Tel
650-6922368
Email
sales@achemblock.com
Country
China
ProdList
2992
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4989
Advantage
58
Henan Weitesi Chemical Technology Co. LTD
Tel
0371-0371-55135753 18003832934
Fax
QQ：2853979818
Email
2853979818@qq.com
Country
China
ProdList
9991
Advantage
58
Chunchuang (Wuhan) Technology Co., Ltd
Tel
15727060112
Email
yutianchun2007@126.com
Country
China
ProdList
9814
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44119
Advantage
58
Changzhou Xiya Biotechnology Co., Ltd.
Tel
13775267187
Email
391097727@qq.com
Country
China
ProdList
996
Advantage
58
Fuxin Pharmaceutical
Tel
021-50872116 13611907556
Fax
021-31300828
Email
contact@fuxinpharm.com
Country
China
ProdList
1611
Advantage
58
Hefei Ruiluo New Material Technology Co., Ltd.
Tel
19567218739
Email
1759672789@qq.com
Country
China
ProdList
868
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58

180181-02-6, Boc-3-amino-2,2-dimethyl-propionic acidRelated Search:

BOC-AMCP-OH 1-[(TERT-BUTYL)OXYCARBONYL]-3-BENZYLPIPERIDINE-3-CARBOXYLIC ACID 1-N-Boc-3-Methylpiperidine-3-carboxylic acid 1-N-BOC-3-(3-BROMOBENZYL) PIPERIDINE-3-CARBOXYLIC ACID 1-[(TERT-BUTYL)OXYCARBONYL]-3-PYRIDIN-3-YLMETHYLPIPERIDINE-3-CARBOXYLIC ACID 1-[(TERT-BUTYL)OXYCARBONYL]-3-(4-CHLOROBENZYL)PIPERIDINE-3-CARBOXYLIC ACID 1,3-Piperidinedicarboxylic acid, 3-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester 1-N-BOC-3-(4-BROMOBENZYL) PIPERIDINE-3-CARBOXYLIC ACID 1-[(TERT-BUTYL)OXYCARBONYL]-3-(4-METHOXYBENZYL)PIPERIDINE-3-CARBOXYLIC ACID 1-[(TERT-BUTYL)OXYCARBONYL]-3-(3,4-DICHLOROBENZYL)PIPERIDINE-3-CARBOXYLIC ACID 1-[(TERT-BUTYL)OXYCARBONYL]-3-PYRIDIN-4-YLMETHYLPIPERIDINE-3-CARBOXYLIC ACID 1-[(TERT-BUTYL)OXYCARBONYL]-3-(4-METHYLBENZYL)PIPERIDINE-3-CARBOXYLIC ACID 1-[(TERT-BUTYL)OXYCARBONYL]-3-(4-FLUOROBENZYL)PIPERIDINE-3-CARBOXYLIC ACID 1-[(TERT-BUTYL)OXYCARBONYL]-3-[4-(TRIFLUOROMETHYL)BENZYL]PIPERIDINE-3-CARBOXYLIC ACID 1-[(TERT-BUTYL)OXYCARBONYL]-3-PYRIDIN-2-YLMETHYLPIPERIDINE-3-CARBOXYLIC ACID 1-N-BOC-3-(2-NITROBENZYL) PIPERIDINE-3-CARBOXYLIC ACID 1-N-BOC-3-(3-NITROBENZYL) PIPERIDINE-3-CARBOXYLIC ACID 1-N-BOC-3-(4-NITROBENZYL) PIPERIDINE-3-CARBOXYLIC ACID

  • Boc-3-amino-2,2-dimethyl-propionic acid
  • 3-(tert-butoxycarbonyl)-2,2-dimethylpropanoic acid
  • Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2,2-dimethyl-
  • 2,2-Dimethyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
  • N-Boc-3-amino-2,2-dimethylpropionic acid
  • 3-((tert-Butoxycarbonyl)aMino)-2,2-diMethylpropanoic acid
  • 3-BOCAMINO-2,2-DIMETHYL-PROPIONIC ACID
  • 3-(Boc-amino)-2,2-dimethylpropanoic acid
  • 2,2-Dimethyl-β-alanine-N-(tert-butoxycarbonyl)
  • tert-butyl 3-allyl-3-hydroxyazetidine-41-carboxylate
  • N-Boc-3-Amino-2,2-dimethyl-propi
  • 3-(Boc-amino)-2,2-dimethylpropionic
  • 3-(tert-butoxycarbonylamino)-2,2-dimethyl-propanoic acid - [B83828]
  • 180181-02-6