ChemicalBook > CAS DataBase List > 5-Bromo-2-fluoropyridine-3-carboxaldehyde
5-Bromo-2-fluoropyridine-3-carboxaldehyde
- Product Name
- 5-Bromo-2-fluoropyridine-3-carboxaldehyde
- CAS No.
- 875781-15-0
- Chemical Name
- 5-Bromo-2-fluoropyridine-3-carboxaldehyde
- Synonyms
- 5-bromo-2-fluoronicotinaldehyde;5-Bromo-2-fluoro-3-formylpyridine;5-Bromo-2-fluoro-pyridin-3-carbaldehyde;5-Bromo-2-fluoro-3-pyridinecarboxaldehyde;5-Bromo-2-fluoropyridine-3-carboxaldehyde;3-Pyridinecarboxaldehyde, 5-broMo-2-fluoro-;5-Bromo-2-fluoropyridine-3-carboxaldehyde ISO 9001：2015 REACH;5-Bromo-2-fluoropyridine-3-carboxaldehyde, 5-Bromo-2-fluoro-3-formylpyridine
- CBNumber
- CB91471279
- Molecular Formula
- C6H3BrFNO
- Formula Weight
- 204
- MOL File
- 875781-15-0.mol
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5-Bromo-2-fluoropyridine-3-carboxaldehyde Property
- Boiling point:
- 258.2±35.0 °C(Predicted)
- Density
- 1.778±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -4.59±0.20(Predicted)
- form
- Powder
- color
- Off-white to pale yellow
- InChI
- InChI=1S/C6H3BrFNO/c7-5-1-4(3-10)6(8)9-2-5/h1-3H
- InChIKey
- MUYVOGAJRCBWCY-UHFFFAOYSA-N
- SMILES
- C1(F)=NC=C(Br)C=C1C=O
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Safety
- Safety Statements
- 24/25
- HS Code
- 29333990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TRC
- Product number
- B685160
- Product name
- 5-Bromo-2-fluoro-3-pyridinecarboxaldehyde
- Packaging
- 500mg
- Price
- $165
- Updated
- 2021/12/16
Frontier Specialty Chemicals
- Product number
- B10986
- Product name
- 5-Bromo-2-fluoro-3-formylpyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $6
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC11103
- Product name
- 5-Bromo-2-fluoronicotinaldehyde
- Packaging
- 1g
- Price
- $12
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 068679
- Product name
- 5-Bromo-2-fluoropyridine-3-carboxaldehyde
- Purity
- >95%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
Frontier Specialty Chemicals
- Product number
- B10986
- Product name
- 5-Bromo-2-fluoro-3-formylpyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $24
- Updated
- 2021/12/16
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5-Bromo-2-fluoropyridine-3-carboxaldehyde Chemical Properties,Usage,Production
Uses
5-Bromo-2-fluoro-3-pyridinecarboxaldehyde is used in the synthesis of [2,3-d]pyrimidine derivatives useful as Raf kinase inhibitors. Also used in the preparation of XIa inhibitors.
Synthesis
2591-86-8
766-11-0
875781-15-0
The general procedure for the synthesis of 5-bromo-2-fluoro-3-formylpyridine using N-formylpiperidine and 2-fluoro-5-bromopyridine as starting materials was as follows: the intermediate 5-bromo-1H-pyrazolo[3,4-b]pyridine was first prepared; subsequently, the crude product was ground in hexane (replacing the operation of crystallization from cyclohexane) according to the method described in WO2006015124 to obtain the target compound 5-bromo-2-fluoro-3-formylpyridine, the product was an off-white solid in 68% yield. Mass spectrometry (electrospray positive ion mode) showed m/z of 203.8 and 205.7 [M+H]+.
References
[1] Patent: US2008/293706, 2008, A1. Location in patent: Page/Page column 27; 85
[2] Patent: US2008/261921, 2008, A1. Location in patent: Page/Page column 73-74
5-Bromo-2-fluoropyridine-3-carboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-2-fluoropyridine-3-carboxaldehyde manufacturers
Hebei Zhanyao Biotechnology Co. Ltd
- Product
- 5-Bromo-2-fluoropyridine-3-carboxaldehyde 875781-15-0
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-10-15
Dideu Industries Group Limited
- Product
- 5-Bromo-2-fluoropyridine-3-carboxaldehyde 875781-15-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-20
Shaanxi Dideu Medichem Co. Ltd
- Product
- 5-Bromo-2-fluoropyridine-3-carboxaldehyde 875781-15-0
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-12
875781-15-0, 5-Bromo-2-fluoropyridine-3-carboxaldehydeRelated Search:
5-Bromo-3-formylpyridine
5-Bromo-2-fluoropyridine
2-Bromo-5-fluoropyridine
5-BROMO-2-FLUORONICOTINIC ACID
2-Fluoro-5-bromo-3-methylpyridine
5-Bromo-2-fluoropyridine-3-carboxaldehyde