PHENYLGLYCINE-01
- Product Name
- PHENYLGLYCINE-01
- CAS No.
- 853138-65-5
- Chemical Name
- PHENYLGLYCINE-01
- Synonyms
- PG 01;PG-01,PG01;PHENYLGLYCINE-01;PG-01 >=98% (HPLC);PG01, 10 mM in DMSO;N-Methyl-N-[2-[[4-(1-Methylethyl)phenyl]amino]-2-1H-indole-3-acetamide;2-[(2-1H-indol-3-yl-acetyl)-methylamino]-N-(4-isopropylphenyl)-2-phenylacetamide;N-Methyl-N-[2-[[4-(1-methylethyl)phenyl]amino]-2-oxo-1-phenylethyl]-1H-indole-3-acetamide;1H-Indole-3-acetamide, N-methyl-N-[2-[[4-(1-methylethyl)phenyl]amino]-2-oxo-1-phenylethyl]-
- CBNumber
- CB91474942
- Molecular Formula
- C28H29N3O2
- Formula Weight
- 439.55
- MOL File
- 853138-65-5.mol
PHENYLGLYCINE-01 Property
- Boiling point:
- 704.6±60.0 °C(Predicted)
- Density
- 1.217±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥10mg/mL
- form
- powder
- pka
- 13.31±0.70(Predicted)
- color
- white to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0027764
- Product name
- PG01
- Purity
- >98.0%
- Packaging
- 1mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- B7545
- Product name
- PG01
- Packaging
- 10mg
- Price
- $282
- Updated
- 2021/12/16
- Product number
- CS-0027764
- Product name
- PG01
- Purity
- >98.0%
- Packaging
- 5mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- CS-0027764
- Product name
- PG01
- Purity
- >98.0%
- Packaging
- 10mg
- Price
- $780
- Updated
- 2021/12/16
- Product number
- B7545
- Product name
- PG01
- Packaging
- 50mg
- Price
- $1190
- Updated
- 2021/12/16
PHENYLGLYCINE-01 Chemical Properties,Usage,Production
Uses
PG01 is a potent CFTR Cl- channel potentiator. PG01 can correct gating defects of CFTR mutants, is effective on b>E193K, G970R and G551D (CFTR mutants) with Kd values of 0.22 μM, 0.45 μM and 1.94 μM, respectively. PG01 is also effective on ΔF508 (Ka of 0.3 μM). PG01 increases ΔF508-CFTR Cl- current after adding Forskolin[1][2].
in vivo
Pharmacokinetic analysis of PG01 in rats is done by serial measurements of plasma concentrations after single bolus infusions (5 mg/kg). PG01 pharmacokinetics fitted a two-compartment model with half-times of ＜5 min and 130 min with volume of distribution 4 L. Microsome metabolism studies and rat pharmacokinetic analysis suggests significantly more rapid metabolism of PG01 than SF-03[1].
References
[1] Pedemonte N, et al. Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating. Mol Pharmacol. 2005 May;67(5):1797-807. DOI:10.1124/mol.105.010959
[2] Caputo A, et al. Mutation-specific potency and efficacy of cystic fibrosis transmembrane conductance regulator chloride channel potentiators. J Pharmacol Exp Ther. 2009 Sep;330(3):783-91. DOI:10.1124/jpet.109.154146
PHENYLGLYCINE-01 Preparation Products And Raw materials
Raw materials
Preparation Products
PHENYLGLYCINE-01 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77