ChemicalBook > CAS DataBase List > 1,3-DIMETHYLURACIL-5-CARBOXALDEHYDE

1,3-DIMETHYLURACIL-5-CARBOXALDEHYDE

Product Name
1,3-DIMETHYLURACIL-5-CARBOXALDEHYDE
CAS No.
4869-46-9
Chemical Name
1,3-DIMETHYLURACIL-5-CARBOXALDEHYDE
Synonyms
1,3-Dimethyl-5-formyluracil;1,3-Dimethyluracil-5-carboxaldehyde;1,3-dimethyl-2,4-dioxopyrimidine-5-carbaldehyde;1,3-dimethyl-2,4-dioxo-pyrimidine-5-carbaldehyde;2,4-diketo-1,3-dimethyl-pyrimidine-5-carbaldehyde;1,2,3,4-tetrahydro-1,3-diMethyl-2,4-dioxopyriMidine-5-carbaldehyde;1,2,3,4-Tetrahydro-1,3-dimethyl-2,4-dioxo-5-pyrimidinecarboxaldehyde;5-Pyrimidinecarboxaldehyde, 1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-;1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde(1,?3-?Dimethyluracil-?5-?carboxaldehyde)
CBNumber
CB91475565
Molecular Formula
C7H8N2O3
Formula Weight
168.15
MOL File
4869-46-9.mol
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1,3-DIMETHYLURACIL-5-CARBOXALDEHYDE Property

Melting point:
122-124 °C(Solv: ligroine (8032-32-4))
Boiling point:
274.1±50.0 °C(Predicted)
Density 
1.408±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
pka
-3.06±0.40(Predicted)
Appearance
Light yellow to brown Solid
Sensitive 
Air Sensitive
InChI
InChI=1S/C7H8N2O3/c1-8-3-5(4-10)6(11)9(2)7(8)12/h3-4H,1-2H3
InChIKey
KGJFRZOATIXYPW-UHFFFAOYSA-N
SMILES
C1(=O)N(C)C=C(C=O)C(=O)N1C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
D462058
Product name
1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde
Packaging
50mg
Price
$90
Updated
2021/12/16
TRC
Product number
D462058
Product name
1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde
Packaging
100mg
Price
$130
Updated
2021/12/16
AK Scientific
Product number
6636AB
Product name
1,3-Dimethyluracil-5-carboxaldehyde
Packaging
100mg
Price
$96
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD147434
Product name
1,3-Dimethyluracil-5-carboxaldehyde
Packaging
100mg
Price
$61
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD147434
Product name
1,3-Dimethyluracil-5-carboxaldehyde
Packaging
500mg
Price
$210
Updated
2021/12/16
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1,3-DIMETHYLURACIL-5-CARBOXALDEHYDE Chemical Properties,Usage,Production

Synthesis

1195-08-0

74-88-4

4869-46-9

A slurry was formed by suspending 400 mg of 5-formyluracil (2.8 mM) in 10 mL of DMF at room temperature. Subsequently, 280 mg of sodium hydride (7 mM, 60% oil solution) was added to this slurry. After stirring the reaction mixture for 30 minutes, 1.013 g of iodomethane (7.2 mM) was added. After the reaction mixture was transformed from turbid to a homogeneous yellow solution and complete consumption of 5-formyluracil was confirmed by thin layer chromatography (TLC), the reaction was quenched with methanol and water. The reaction mixture was concentrated on a rotary evaporator and the residue partitioned between methanol and hexane. The methanol phase was concentrated and the residue was again partitioned between chloroform and water. The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated to give 420 mg (89% yield) of 1,3-dimethyl-5-formyluracil as an off-white waxy solid. The structure of the product was confirmed by 1H-NMR (DMSO-d6, δ= 9.82 (s, 1H), 8.52 (s, 1H), 3.43 (s, 3H), 3.2 (s, 3H) and LC/MS (retention time = 0.34 min, m/z = 169, [M+H]+).

References

[1] Patent: US2006/19965, 2006, A1. Location in patent: Page/Page column 22
[2] European Journal of Organic Chemistry, 2015, vol. 2015, # 30, p. 6624 - 6630

1,3-DIMETHYLURACIL-5-CARBOXALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1,3-DIMETHYLURACIL-5-CARBOXALDEHYDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
1,3-DiMethyluracil-5-carboxaldehyde 4869-46-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-14

4869-46-9, 1,3-DIMETHYLURACIL-5-CARBOXALDEHYDERelated Search:

1,3-DIMETHYLURACIL-5-CARBOXALDEHYDE 5-ACETYL-1-(4-CHLOROPHENYL)-3-(4-FLUOROBENZYL)-2,4(1H,3H)-PYRIMIDINEDIONE 6-AMINO-1,3-DIMETHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBALDEHYDE 1-(2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)ETHYL)-3-METHYL-5-(3-[4-(TRIFLUOROMETHYL)ANILINO]ACRYLOYL)-2,4(1H,3H)-PYRIMIDINEDIONE AURORA KA-5012 AURORA KA-5089 1-(4-CHLOROPHENYL)-5-[3-(DIMETHYLAMINO)ACRYLOYL]-3-(4-FLUOROBENZYL)-2,4(1H,3H)-PYRIMIDINEDIONE 5-BENZOYL-6-CHLORO-1,3-DIMETHYL-1,2,3,4-TETRAHYDROPYRIMIDINE-2,4-DIONE AURORA KA-5088 1-BENZYL-5-[3-(DIMETHYLAMINO)ACRYLOYL]-3-(4-FLUOROBENZYL)-2,4(1H,3H)-PYRIMIDINEDIONE AURORA KA-5094 1-BENZYL-3-(4-FLUOROBENZYL)-5-[3-(4-METHOXYANILINO)ACRYLOYL]-2,4(1H,3H)-PYRIMIDINEDIONE 5-ACETYL-3-(4-BROMOBENZYL)-1-(4-CHLOROPHENYL)-2,4(1H,3H)-PYRIMIDINEDIONE 5-ACETYL-1-BENZYL-3-(4-FLUOROBENZYL)-2,4(1H,3H)-PYRIMIDINEDIONE 1-(2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)ETHYL)-5-[3-(DIMETHYLAMINO)ACRYLOYL]-3-METHYL-2,4(1H,3H)-PYRIMIDINEDIONE AURORA KA-5097 AURORA KA-5092 AURORA KA-5100

  • 1,3-Dimethyluracil-5-carboxaldehyde
  • 1,3-dimethyl-2,4-dioxo-pyrimidine-5-carbaldehyde
  • 1,3-dimethyl-2,4-dioxopyrimidine-5-carbaldehyde
  • 2,4-diketo-1,3-dimethyl-pyrimidine-5-carbaldehyde
  • 1,3-Dimethyl-5-formyluracil
  • 1,2,3,4-tetrahydro-1,3-diMethyl-2,4-dioxopyriMidine-5-carbaldehyde
  • 5-Pyrimidinecarboxaldehyde, 1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-
  • 1,2,3,4-Tetrahydro-1,3-dimethyl-2,4-dioxo-5-pyrimidinecarboxaldehyde
  • 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde(1,?3-?Dimethyluracil-?5-?carboxaldehyde)
  • 4869-46-9